Many recommendations, protocols describe the indications for starting medication, but only some of them indicate when they should be discontinued. An analysis of publications indicates a deficit of research in this area, especially in psychiatry. As part of this review, we tried to provide information that provides valuable information about this procedure, about the experience of other countries. Based on a literature review, it was found that in some countries there is already consensus on how to identify a patient who may be reevaluated, recommendations and algorithms have been developed for this procedure with minimal risk to the patient.

Obesity is a common problem among women of reproductive age. Overweight is known to negatively affect a woman’s fertility. So, women of reproductive age who are obese may experience menstrual irregularities, endometrial pathology and, ultimately, infertility. The pathogenetic mechanisms of reproductive dysfunction in obesity remain actively studied issues. It was established that leptin synthesized by adipose tissue inhibits granulosis, cell steroidogenesis and interferes with the ovulation process, which can directly affect reproductive function. Insulin resistance and compensatory hyperinsulinemia, which accompany obesity in women, can contribute to menstrual irregularities, ovulation and, ultimately, fertility. Obesity is also characterized by a state of «relative functional hyperandrogenism», which can affect ovarian function, contributing to the development of infertility. Moreover, obesity is characterized by a state of hyposomatotropinism, which can affect fertility, through changes in ovarian and endometrial function. Weight loss is most likely able to restore fertility in most cases, but there are no practical guidelines that would help the clinician choose the best method to reduce body weight from increased physical activity, dietary restrictions, drug therapy and bariatric surgery.

The article presents a review of the literature on the problems of treatment of obstetric bleeding in the light of historical development and modern opportunities. Currently existing options for surgical hemostasis: ligation of pelvic vessels, ligation of internal iliac arteries, embolization of uterine arteries and compression sutures on the uterus are considered from the perspective of experimental work and clinical research. The paper reflects the opinions of domestic and foreign scientists, which were a vector for further study and experiments.

The review presents a description of the specific laboratory testing of SARS-CoV-2. The effectiveness of certain types of tests depending on the set medical and epidemiological tasks is shown. The importance of using certain diagnostic methods for mass and rapid testing of patients for a new coronavirus infection, which will speed up their detection, was also noted. The effectiveness of using test systems that can be used in outpatient settings without the presence of a stationary laboratory in a medical facility is shown, which will simplify and increase the throughput of medical institutions that perform SARS-CoV-2 diagnostics. This review will be useful for both medical professionals of laboratory specialties and all clinical doctors who are currently working with a new coronavirus infection.

Purpose: to develop an effective and safe method for the etiopathogenetic treatment of influenza patients, aimed at increasing the effectiveness of the existing standard treatment using the antiviral drug oseltamivir.

Materials and methods: 150 patients with a verified diagnosis of influenza were taken under observation. All of the participants were divided by randomization into two groups (n1 = 77, n2 = 73) which had the same initial clinical and laboratory characteristics. I group’s patients received standard antiviral therapy using oseltamivir. Patients of the II group at the same time as oseltamivir additionally received an aqueous solution of rehydron for 5 days. All patients underwent determination of the acidity of the mucous membrane of the oropharynx immediately before the start of antiviral therapy and immediately after its completion.

Results: patients additionally receiving rehydron had a more rapid leveling of the main symptoms of influenza and a decrease in the frequency of its complications compared with people who received only standard treatment.

Conclusions: the developed method of etiopathogenetic treatment of patients with influenza is characterized by a proven level of effectiveness, which is associated with the corrective effect of rehydron on the acid-base balance of the mucous membranes of the respiratory tract. The data obtained in the course of the study indicate not only the absolute scientific novelty of the developed method, but also its applied significance for practical public health.

Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.

Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.

Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.

Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.

Objective: conduct molecular genetics diagnosis of SARS-CoV-2 in asymptomatic individuals in the Rostov region.

Material and methods: 22037 individuals who at the time of delivery of the material did not have clinically expressed symptoms of respiratory disease COVID-19 were examined. Molecular genetics diagnosis of SARS-CoV-2 was carried out by RT-PCR and LAMP with manual and automatic isolation of viral RNA.

Results: a positive result would be detected in 297 individuals, the result would be confirmed by the regional reference center in 149 people (0.68 %). Among the total sample, 3090 “contact” patients were examined (78 people, or 2.52 %) found positive results, 8109 medical workers (23 cases positive, or 0.28 %) and 3098 “contact” health workers (24 cases positive, or 0.77 %).

Conclusions: based on the results obtained, it can be concluded that the use of molecular genetic testing of SARS-CoV-2 for the detection of asymptomatic cases has serious limitations, therefore, for this diagnostic task, it is necessary to develop alternative laboratory diagnostic methods based on the features of the etiopathogenesis of a new coronavirus infection.

A clinical case of congenital hyperinsulinism, diffuse form, pharmacoresistant course (heterozygous mutation of p. 1361 1363 dup CGG in the GCK gene) in an early child is presented as an example of an orphan severe disease with an extremely unfavorable course and a probability of deterioration of the long-term prognosis. The goal was to highlight the clinical manifestations, course options, and complexity of treatment of this pathology to a wide range of doctors of different specialties in the field of Pediatrics in terms of improving the quality and timeliness of diagnosis, reducing the number of complications with the formation of irreparable consequences. Attention is drawn to the most severe course of hypoglycemic conditions in the early neonatal period, the dependence of the formation of a pronounced neurological deficit on the degree and duration of hypoglycemia, which emphasizes the importance of their timely correction to preserve the quality of life of this contingent of children.

A retrospective analysis of the course of pregnancy and childbirth during the birth of a child with a congenital pathology «ichthyosis» was carried out. This clinical case is interesting because fetal ichthyosis was not diagnosed during pregnancy, but all the signs of this disease were revealed in the newborn after the birth.

A clinical observation of a patient with Swyer's syndrome is presented. The article presents anamnesis data, phenotypic signs, clinical symptoms and objective data of the patient, the results of instrumental and hormonal studies, on the basis of which doctors of different specialties may suspect a violation of sex formation with XY gonadal dysgenesis.

Objective: monitoring, analysis and forecast of the spread of new coronavirus infection (COVID-19) in the Rostov region.

Materials and methods: analysis of data on the incidence of COVID-19 in the Rostov region, obtained on the basis of agencies: Department of the Federal service for supervision of consumer protection and human welfare in the Rostov region, Center of hygiene and epidemiology in Rostov region, Rostov research Institute of Microbiology and Parasitology, as well as the monitoring of information on the Internet sites of the Government of the Rostov region and the regional headquarters for the fight against the spread of COVID-19. Application of the SEIR analytical platform to build a mathematical model for predicting the spread of infection in the Rostov region.

Results: the article presents an analysis of the epidemiological situation for the incidence of COVID-19 in the Rostov region, analyzes the effectiveness of preventive and anti-epidemic measures with the ability to predict the development of the epidemiological process in the region.

Objective: to study the sanitary condition of various environmental objects of the Rostov region and the degree of their contamination.

Materials and methods: in the period from 2015 to 2019, more than 5600 sanitary and parasitological studies of environmental objects of the Rostov region were performed on the basis of the Rostov Research Institute of Microbiology and Parasitology: waste water and its precipitation, soil, water of open surface reservoirs. The work was carried out in accordance with the accepted normative documents.

Results: it was found that 33.4 % of all tested samples were positive, and 1.4% of the samples contained viable eggs of various pathogens of helminthiasis and did not meet the requirements of regulatory documents.

Conclusions: the results of the study indicate that the environmental objects of the Rostov region are polluted with parasitic pathogens and their unsatisfactory sanitary and parasitological condition.