Lung cancer – one of the most common malignancies in the world. Currently, domestic publications addressing issues of classifi cation, clinic, diagnosis, treatment, a form of lung cancer - non-small cell cancer, is extremely small. Th erefore, our work makes up to some extent this gap. Th is review of literature devoted to small-cell lung cancer, the tumor has an aggressive clinical course and poor prognosis. Th e review considers the epidemiology, clinical and morphological classifi cation of small cell lung cancer; it is recommended the most appropriate clinical classifi cation, which classifi es tumors into two forms — limited or local and extensive. Th e paper focuses on the standard options of treatment of limited form and extensive form of non-small cell lung cancer. In the treatment of limited form confi rmed the primary role of chemotherapy with radiation therapy, combination chemotherapy, surgery followed by chemotherapy or chemoradiotherapy. For the treatment of extensive form shown in the use of such treatment options as combination chemotherapy and radiotherapy. It noted the successes and shortcomings in the treatment of this tumor chemotherapy, radiation therapy, and combination therapy, and also points to the development of new schemes and treatment combinations with greater effi ciency and less toxicity for patients. Separately, the issues of treatment of small cell lung cancer recurrence and noted the major role in the treatment of chemotherapy and palliative care. Th e importance of brain irradiation in reducing recurrence and increase survival in this pathology.

Arterial hypertension remains the leading cause of death in the world and one of the global problems of the world healthcare.
Left ventricular hypertrophy is a frequent complication of arterial hypertension, which in turn is a powerful independent predictor of morbidity and mortality. With a prolonged course of the disease, there are several models of remodeling the left ventricle. In this connection, this literature review presents diff erent points of view on the problem, as well as directions for further fundamental and practical research.

It is known that coronary atherosclerosis has more severe consequences if there is a patient of diabetes, as the combination of these two factors signifi cantly increases the risk of manifestations of CHD, oft en combined with prolonged atherosclerotic plaques in the coronary artery, multivessel coronary artery disease, lesions of the left coronary artery. In this regard, an increasing number of patients are becoming candidates for a revascularization of a myocardium. Despite signifi cant advances in endovascular surgery, the results of coronary stenting in diabetic patients remain worse than in CHD patients without diabetes. Th e results of large-scale studies testify to the undoubted benefi ts of carrying out coronary artery bypass graft ing (CABG) in diabetic patients, with their characteristic multi-vessel lesion of coronary arteries

Objective: to evaluate accuracy of computed angiography in preoperative assessment of carotid occlusive disease. Material and Method: During 2013-2016 years 256 patients underwent preoperative examinations, that included ultrasound (study of brachiocephalic arteries (BCA), transcranial Doppler and computed angiography (CTA). Received with computed angiography data were analyzed with criteria NASCET (North American Symptomatic Carotid Endarterectomy Trial) and ECST (European Carotid Surgery Trial). Results: Unilateral occlusive disease was observed in majority of patients, occlusive lesions in carotid arteries was usually accompanied with changes in other vascular territories. In 29 cases (11%) in patients with internal carotid subocclusion (ICA) a distal diff use narrowing of lumen was observed. Comorbid diseases that aff ect management of our patients were: intracranial aneurysms (4%), lesions of larynx and pharynx (1%), lung cancer (1%). Conclusion: Computed angiography is necessary for carotid surgery planning.

Objective: to improve the results of complex treatment of patients with trophic venous ulcers of the lower extremities by developing and introducing new methods of pharmacotherapy with morphological, immunohistochemical and biochemical evaluation of the reparative processes. Materials and methods: 72 patients with chronic venous insuffi ciency of C6 class under CEAP, in two clinical groups, underwent complex treatment and morphological features of trophic ulcers biopsies and monitoring of neopterin level were prospectively studied. In both groups, multicomponent antibacterial water-soluble ointments were used for topical treatment, which was supplemented with compression therapy and use of phlebotonics. Th e fi rst group consisted of 52 patients who additionally received magnesium orotate and enterosorption with dioctahedral smectite in the complex treatment of trophic ulcers, and the second group included 20 patients who did not receive the proposed additional therapy. Results: The effectiveness of the combined use of magnesium preparations and enterosorption has been proved. Conclusion: Th e inclusion of preparations of organic magnesium and enterosorption in complex treatment of trophic ulcers of venous etilogy allows the accleration of the healing process and shorten the period of stay of patients in the hospital.

Objective: testing applications of aerocryothermal training (ACT) to emergency increase the cold resistance of persons exposed to low ambient temperatures. Materials and methods: the study involved 25 men at the age of 20-35 years (mean age of 28.2±2.1 years) who completed the ACT: 10 procedures of 2-5-minute stay in the cryochamber at a temperature of -150 ± 20C, in the process of which were evaluated parameters of thermal status and the reactivity of the indicators of systemic circulation.
Results: as a result of ACT took place a gradual increase in stability of the subjects to hypothermia. Th is was evidenced by improved subjective tolerability eff ects, lengthening the time maximum duration of hypothermia (average 40% compared with the 1st procedure), slowing the rate of fall of rectal temperature (average 19%), reducing the reactivity of the indicators of system of blood circulation in hypothermia (average of 23-40%). Conclusion: aerocryothermal training is highly eff ective non-drug means to enhance the person sustainability to exogenic hypothermia.

Objective: researching of the clinical and anamnestic features of pregnant women have a 1-trimester abortion threat with the formation of a subchorionic hematoma (SCH), living in the Rostov region, and fi nd clinical and anamnestic risk factors of subchorionic hematoma. Materials and methods: in a study performed in State budgetary institution of the Rostov region Perinatal Center in years 2013-2016, 270 pregnant women with subchorionic hematoma in the period of 6-12 weeks of pregnancy and 79 pregnant women without subchorionic hematoma (relatively healthy) were included. Results: according to the study, the clinical and anamnestic features of the subchorionic hematoma in the Rostov region are lower body weight and body mass index, and the presence of uterine fi broids. Th e risk of subchorionic hematoma increases 19 times if woman has non-developing pregnancy history,
8.5 times — reccurent miscarriage, 7.5 times — perinatal losses. Conclusion: history of early pregnancy losses, both single (one spontaneous abortion or one non-developing pregnancy) and two or more early reproductive losses, history of perinatal loss increase the risk of subchorionic hematoma in a case of pregnancy.

Purpose: to evaluate the role of immunocorrection in the complex pregravidational preparation for IVF for the restoration of the endometrial implantation potential in patients with grade 1-2 adenomyosis. Materials and methods: By simple randomization, the patients were divided into two groups: 1 group of 45 patients — complex pregravidational preparation. (PGP), including reception of dienogest at a dose of 2 mg per day for 3 months and intravenous administration of deoxyribonucleinate at a dose of 75 mg, group 2 — 43 patients — GWP, including reception of dienogest at a dose of 2 mg per day for 3 months. Th e control group (group 3) consisted of 45 healthy fertile women. Initially, and in dynamics, LIF, LIF-R, IL-6, IL-10 in cervical mucus were determined by the method of enzyme immunoassay. Results: A comparative analysis of pre-gravitational preparation for the IVF cycle in patients with infertility associated with adenomyosis of 1-2 degrees and the implantation potential of the endometrium as much as possible reduced against this background. Isolated use of dienogest and complex therapy (dienogest + deoxyribonucleate sodium) was used. Th e analysis of the indicators took into account the infl uence of various methods of pregravidational preparation on the local cytokine balance (IL, IL10) and indicators characterizing the implantation potential of the endometrium (LIF and LIF-R). Conclusion: complex pregravidational preparation provides a full recovery of the implantation factor of the endometrium, which is confi rmed by an increase in the frequency of biochemical and clinical pregnancy.

Objective: the study of bioinformatics by six genetic polymorphisms (rs1782507, rs555621, rs7753051, rs887912, rs6732220, rs4986938) in the formation of a combination of endometrial hyperplasia with uterine myoma in women in the Central region of Russia. Materials and methods: the study group consisted of 1151 employees, including 170 patients with a combination of uterine fi broids with endometrial hyperplastic processes and 981 women in the control group without proliferative diseases of the pelvic organs. Material for the study were DNA samples isolated from venous blood by phenol-chloroform extraction.
Analysis of the investigated polymorphisms was carried out by the detection ATK-man probes using real-time PCR. Results: risk factors for the development of a combination of endometrial hyperplasia and uterine fi broids combination of molecular genetic markers with rs673220, and rs4986938 and G rs887912 (ОR = 1.70), with rs6732220 and rs555621, g rs887912 (ОR = 1.53) and C rs1782507 T rs7753051 and rs887912 G (ОR = 1.40). Conclusion: the obtained data testify to the signifi cant contribution of combinations of polymorphic variants rs1782507, rs555621, rs7753051, rs887912, rs6732220 and rs4986938 to the formation of a combination of endometrial hyperplasia and uterine fi broids among women in the Central region of Russia.

Objective: to give assessment of the effi cacy and safety of using asunaprevir in combination with daclatasvir in patients with chronic hepatitis C (HCV) with severe fi brosis and cirrhosis. Materials and methods: a prospective cohort clinical trial involved 50 patients with HCV (including 30 patients with compensated cirrhosis of the liver, class A in Child-Pugh), caused by genotype 1b. All patients received asunaprevir in a dose of 100 mg twice a day in combination with daclatasvir 60 mg once a day. Th e duration of the treatment course was 24 weeks. Th e effi cacy criterion was the undetectable level of HCV RNA 24 weeks aft er the end of antiviral therapy (SVR24). Results: at the end of the 4th week of treatment, aviremia was achieved in 92% of patients. Th e incidence of SVR24 in previously untreated patients was 90%, in the group of patients who did not respond to previous therapy with pegylated interferon-interferon with ribavirin- 86.9%. Conclusion: Th e combination of asunaprevir with daclatasvir is highly eff ective and provides a sustained virologic response in 86-90% of cases. A low incidence of adverse events (8%) demonstrates a favorable safety profi le of this treatment regimen.

Objective: to determine the association between MMP and TIMP genetic polymorphisms and GP risk. Materials and methods: Th e study involved 178 women aged 35 to 65, 134 of them with GP relapses (aft er hysterectomy by vaginal access because of a total and partial uterus and vaginal walls prolapse). Patients were randomized into the following groups: I – with manifestations of undiff erentiated connective tissue dysplasia (CTD)(11.7 points on average)(n = 86); II – with no CTD signs (n = 48). Control group III consisted of healthy women without any GP signs (n = 44). Used: genotyping by polymerase chain reaction of MMP / TIMP polymorphisms with separation of DNA samples from whole blood. Results: Statistically signifi cant diff erences were revealed in the distribution of polymorphisms frequencies in groups with GP and CTD signs compared to healthy women: MMP9 (rs3918242), ММР9 (rs17576); ММP3 (rs3025058); ММР2 (rs2285053)(rs2285052). Th e probability of pelvic fl oor failure increased while identifying genotypes: СТ gene MMP9 (OR=3,2; 95% CI 1,3-7,6), AG gene ММР9 (OR=2,9; 95% CI 1,2-7,0); 5A6A gene ММP3 (OR=3,7; 95% CI 1,3-10,1); СТ gene ММР2 (OR=3,2; 95% CI 1,3-7,5). Conclusion: Identifi cation of genetic predictors of pelvic fl oor remodeling with the formation of its insolvency contribute to better understanding of the pathogenesis of the disease and allow to stratify women into risk groups of GP development, progression or recurrence aft er surgery.

Priority directions of improving the organization of work of the municipal outpatient urological service in the new economic conditions is the formation of an eff ective economic mechanism on the basis of the MPP principles in outpatient institutions providing urological assistance, an example of which is the development of the functional and organizational structure of the regional ACC model on the principles of the MPP.

Purpose: the determination of risk areas in the Rostov region of anthrax for improving epidemiological surveillance of this infection with the use of GIS-technologies. Materials and methods: data on the incidence of anthrax in people and animals, the anthrax burials sites of animals in the Rostov region were used; epidemiological and statistical methods and the method of computer simulation in this article were used. Results: a complex risk assessment allowed determining the anthrax epizootic and epidemiological danger degree for each district of the Rostov region and identifying areas of increased risk. Conclusions: conducted zoning of the territory of the Rostov region for anthrax will help improve the epidemiological surveillance of this infection.