There are considered the contemporary views on the non-drugs methods of preventive oncology, and some recommendations on working out and use the programs with exercises and diet for primary and secondary prevention of oncologic diseases and for rehabilitation of patients with various types of cancer. It were discussed also some facilities to reduce disease- and treatment- induced fatigue.

Electroencephalography (EEG) is a useful method for examination of patients with several types of neurological disorders, including cerebral ischemia, encephalopathy and etc. Quantitative or computerized techniques, referred to as a quantitative electroencephalography (QEEG), have been developed to assist in improving of EEG interpretation process. The quantitative approach can display progressive changes in neurophysiological function over time. Computer-analyzed EEG studies indicates: drugs with similar psychotropic activities (for example, antidepressants, anxiolytics) have similar QEEG profiles. This allows the prediction of untested new drugs’ clinical activities and promotes psychotropic drugs’ development. The characteristic features of nootropics-induced EEG changes includes an increase of α- and β-rhythms power and reduction of Δ-rhythm power. The EEG indices of drug nootropic activity are the most obvious in cerebral vascular diseases.

Although of existing guidelines and a lot of scientific publications of the management and care in patients with vesicoureteral reflux (VUR), up to now there isn’t the universally accepted algorithm for ideal treatment in children with such disorder. In during 70 years of intensive study of the problem of reflux, the balance periodically tends either towards the conservative, or to the surgical approach, was accumulated sufficient experience in open, minimally invasive surgery, and in the conservative treatment. The 10-years using of the recommendations of the European Association of Urology (EAU) provided experience and allowed to transform approaches to the selection of treatment for patients with vesicoureteral reflux.

An age of the porotsystemic surgery of portal hypertension is estimated near of 150 years. Such complications as esophageal varices, ascitis, splenomegaly, hepatic encephalopathy requires to decrease the pressure in portal vein system effectively. Otherwise, variceal esophageal bleeding, hepatorenal syndrome, hypersplenism and coma, would be lifethreatening conditions with frequent fatal outcome for patient. 100 years ago Prof. Nikolay Bogoraz proposed mesentericocaval shunt. So, this method of portal decompression is actual up to modern times. A spectrum of surgical interventions for portal decompression is multiplied, but transabdominal operations are intolerable frequently by majority of patients with advanced hepatic insufficiency. Transjugular intrahepatic portosystemic shunt (TIPS procedure) represents as method of choice with high clinical effectiveness and low traumatism.

Different groups of non-steroidal anti-inflammatory remedies are analyzed in respect of its efficacy and safety. The information concerning gastric and intestinal sequelae is presented. The approaches in treatment of NSAI-gastropathy are shown in dependence of Helicobacter pylori involvement into the affection.

Purpose: To study the rate of infection of population of the Rostov region by the virus of tick-borne encephalitis (TVE) and in analyzing the pre-conditions of its possible circulation.Materials and methods: Data from relevant literature sources, results of regional entomological study, blood sera samples from donors of the Rostov regions and patients of infectious and neurologic units at the Rostov hospitals in 2009-2012 have 39Медицинский вестник Юга России ОРИГИНАЛЬНЫЕ СТАТЬИbeen used as the material for analysis. We have used methods of scientific and informational search, as well as analytical and immunoserological methods.Results: Results of the study have revealed the existence of Ig G class antibodies to the etiological agent of encephalitis in donor blood sera on the territory of five areas and two cities. In blood sera of the patients of neurologic and infectious units of the Rostov hospitals the Ig G antibodies to the virus of tick-borne encephalitis haven’t been found. Existence of favorable conditions as well as forest resources along with the prevalence of I. ricinus tick species and animals - potential reservoirs of the virus - serve as prerequisites for virus circulation in northern and northwestern areas of the Rostov region.Summary: For determination of virus circulation there is will be necessary to study the existence of the virus of tick-borne encephalitis in vectors-ticks and their possible hosts.

Purpose: To improve the results of restorative surgical treatment of patients after obstructive resection of the distal colon. Materials and methods: The analysis of surgical treatment results at 30 patients who had operations on restoring the intestinescontinuity after obstructive resections of distal segments of a large intestine has been carried out (operations of Hartmann type).Results: The algorithm of defining the timeframes and way of operations on restoring large intestine continuity has beendeveloped. The priority value in the choice of length and functional condition of a postcolostomic stump medical tactics, changesof its microflora, as well as function of the rectal locking apparatus has been established.Summary: The obtained results (93,3% of favorable outcomes without complications) allow to recommend the offered tactics(including preventive methods of anastomosis incompetence and transanal decompression of the intestines) for wide practicalapplying.

Purpose: To determine the influence of the changed production of bioactive components on the trophoblast invasion disorders and as a result development of preterm delivery.Materials and methods: 69 pregnant women were under observation, among them there were 48 women with the threatened miscarriage in the 1st trimester and preterm delivery and 21 women with physiological gestation. The determination of the content of glycodelin-A, follistatin, IL-1β and TNF-α in the blood serum during the 1st trimester and in case of preterm delivery in the 34th - 37th weeks was realized by means of immunoenzyme method.Results: An evident imbalance of intracellular bioregulators that determine nidation of the ovum and chorion formation was revealed.Summary: A high level of TNF-α causes the disorder of calcium ion concentration in myometrium cells that leads to initiation of preterm delivery.

Purpose: evaluation of stress-protectors therapeutic potential in correction of experimental parodontitis combined with emotional stress.Materials and methods: 30 three-months outbred white male rats weighted 190,2±2,23 g were randomized in 6 per serium: intact control, combined stress and inflammation, use of piracetam, thyotriazolin, thyocetam after modeling. Inflammation was created by sodium hydroxide 4 % solution, stress - by immobilization of rats in cage-penals.Results: Stated earlier stressogenous character of inflammation was amplified by immobilization was found in chronic experiment as less alterative compating with acute. Use of thyocetam supports spleen mass coefficient, adrenal ascorbic acid, oxidation balance at control levels, stabilizes summarized-threshold parameter and behaviour reactions in “open field”, prevents blood pressure and pulse rate rise. Same-directed but less expressed effects were genuine for separate thyocetam components.Summary: Thyocetam (250 mg/kg) has antistress action in experimental modeling of oral mucosa inflammation and immobilization stress. Stress-protective capabilities of its components may be a result of potentiation: piracetam (200 mg/kg) and thyotriazolin (50 mg/kg). Use of combined preparation thyocetam in treatment of oral mucosa inflammational diseases on the background of stress is pathogenically approved and effective comparing with its components in these doses.

Purpose: Assess the long-term results of surgical treatment for the determination of arterial reconstruction.Materials and methods: The results of surgical treatment of 227 patients with atherosclerosis and critical ischemia of the lowerlimbs.Results: Given the risk of complications the best results are obtained with a combination of open methods of restoring bloodflow with X-ray endovascular interventions. Draws attention to the importance of the vascular bed of leg. Restoration of bloodflow in it gives the advantage of both the speed of elimination of critical ischemia, and in the duration of the period of remissionand functioning grafts. Comparing the examined groups by time and frequence of occurrence of thrombosis and the need forre-reconstruction obtained statistically significant indices.Summary: Noting the positive effect of stimulation of angiogenesis on the results of surgery.

Purpose: To evaluate the role of statement, classification and comparison of final clinical and pathologic diagnosis in the structure formation of maternal losses,Materials and Methods: A posthoc analysis of medical records of 74 deaths of pregnant, parturient and puerperal women, registered in the obstetrics institution in the Rostov region from 2000 to 2007.Results: Non-classified final clinical diagnosis (chronological registration of symptoms, lack of headings of underlying disease, fatal complications, accurate dating of surgical measures and major components of remedial and resuscitation measures) objectively reflects the diagnosis defects of prime causes of maternal deaths and wrong treatment policy.Summary: Detailed clinical analysis of the causes of maternal deaths, comparison of the final and pathologic diagnosis clarifies the actual nosological profile of maternal mortality and its intensive parameters, as well as determines the reserves of its further decrease.

Purpose: To study the influence of polymorphism µ-opioid receptor for the total intravenous anesthesia.Materials and methods: The study included 100 patients, which were performed by various gynecological operations withthe entry into the abdominal cavity. Intraoperative in all patients evaluated the change bispectral index, blood pressure, oxygensaturation. Analyzed the frequency of the polymorphism of gene mu-opioid receptor OPRM1 (A118G).Results: We found that the carriers of polymorphic genotype of the study of the gene was observed increased consumptionof narcotic analgesics during the operation, later performed extubation, often recorded postoperative complications (nausea andvomiting) and there was a higher score on the visual-analogue scale in the early postoperative period.Summary: The carriers of polymorphic genotype of µ-opioid receptor А118G, as heterozygous and homozygous are need ofhigher doses of narcotic analgesics during surgery and the more careful observation in the early postoperative period because ofthe possible complications.

Purpose: To demonstrate the need of rehabilitation actions for patients, nearly died from aborted tubal pregnancy.Material and Methods: Comparative clinical analysis of two groups of patients (1st and 2nd) after tubectomy due to abortedtubal pregnancy and different blood loss. The blood loss in 1st group did not exceed 500 ml, and in 2nd group (nearly diedpatients - «near miss») - more than 1500 ml. The 3 group was contained of died patients.Results: It was identified a significant causal dependence of pathomorphological changes of anterior pituitary and adrenal glandfrom the blood loss volume, characterizing compensatory mechanism in acute adrenocortical insufficiency, attributable to anyshock, including posthemorrhagic. The data, obtained in the group of maternal deaths, allow to extrapolate the identified changesand suppose the development of these changes for patients, nearly died from major bleeding due to aborted tubal pregnancy.Summary:The presented data of autopsy of characteristic morphological changes of anterior pituitary and adrenal gland,depending on the blood loss volume, determine the direction of rehabilitation for «near of miss» patients.

Purpose:to examine characteristics of parodontitis with periapical infection and the dynamics of parodontal status in the combined treatment of periodontal and endodontal.Materials and methods:34 were patient with infectious pathology of parodontal disease: 16 patients with parodontitis and availability simultaneously with signs of chronic periodontitis top (Group 1) and 18 of the patients with parodontitis and lack of periapical infections (Group 2). An index score of parodontal tissue in dynamics of combined endodontic and parodontic treatment.Results:In Group 1 after the elimination of infection in the parodentium apical hygiene indexes (plaque and tartar), bleeding, gingival and parodontal indexes declined with greater intensity and in a shorter time compared with 2 group, reflecting a more favourable dynamics of gums, parodontal hygiene and hard tissues of the mouth with the combined endoparodonta treatment l.Conclusion: endodontic treatment is a necessary part of a comprehensive treatment of endoparodontal syndrome. Termination of pathological processes in the apical periodontal parodontal status of marginal saniruet, helps reduce inflammatory reactions in the parodontium of high gradient with bone regeneration of alveoli in the short term.

Purpose. To research possible interactions of 2-methyl-3-phenylaminomethylquinolin-4-one (3-AMQ) with CNS stimulants and depressants.Materials and methods. The interaction of the said substance with strychnine and thiosemicarbazide was studied on the seizure models, with caffeine - in the open field test, with CNS depressants (sodium thiopental, ethanol) - measuring duration of the anesthetic sleep.Results. The trend of attenuation of strychnine and thiosemicarbazide convulsive action was revealed on seizure models for 3-AMQ. In the open field test 3-AMQ leveled the anxiogenic effects of caffeine that was reflected in the exploratory activity increase. The trend of elongation of narcosis induction time (up to 18%) and reduction of narcosis duration (up to 17%) was found in the model using thiopental-induced anesthesia. In the ethanol-induced narcosis 3-AMQ reduced the duration of animals’ anesthetic sleep by 19.2% (p<0.05).Summary. The absence of pro-convulsive properties and potentiating interactions with barbiturates was proved for 3-AMQ. Beneficial modulating influence on effects of caffeine was revealed. The alcoprotective activity of 3-AMQ was proved.

Purpose: To evaluate the regenerative capacity of the mucous membrane of the maxillary sinus and osteogenesis in the application of firm brain envelope-bearing cells and allografts (TMO) and bone at perforation during a sinus inlay. Materials and methods: An experimental study conducted at 12 pigs. All completed 24 operational intervention. Over 6 months after the operation and close the defect with the maxillary sinus bottom-bearing cells and allografts from TMO had histological study of samples of bone tissue and mucous membranes.Results: On the surface of the top gnathic sinusitis sinus mucosa, TMO is restored with all its characteristic structural elements. Summary: It is proved that the application of the effective-bearing cells and allografts for bone defect and reconstruction ofmorphological and functional capacity of the top gnathic sinusitis sinus mucosa.

Purpose: to assess the quality of life in patients with acute coronary syndrome in combination with type 2 diabetes.Materials and methods: interviewed 130 people, matched by age. Assessment of quality of life was assessed with the help ofa questionnaire WHOQOL BREF, which consists of 26 questions evaluating the 4 areas of quality of life: physical, psychological,social and natural environment. Evaluation of the results was performed according to the scale presented in the instructions to thequestionnaire. The grid presents from 0 to 100 and, respectively, the higher the score, the higher the quality of life.Results: patients with acute coronary syndrome without type 2 diabetes and associated with type 2 diabetes, there is a decreaseof quality of life mainly in the physical, psychological and social spheres.

Purpose: To investigate the dynamic changes of immune system in aesthetic patients treated with botulinum toxin type A. Materials and methods: The study involved 20 patients treated with botulinum toxin type A to reduce mimic wrinkles.Phenotypic and functional characteristics of immune cell were investigated during the study. Immune parameters were discovered before and in 14 and 90 days after injections with standard immunological methods as a flow cytometry, immunodiffusion in Manchini test and enzyme immune test.Results: During the study a positive clinic aesthetic effect and differences in immune status were observed in all patients. Parameters of immune system in 2 weeks after injection were characterized by increasing of immune suppression, rising cytotoxic activity of T-cells and activation of IF-γ synthesis. It results in overweight of antiinflamatory cytokines compared with proinflamatory cytokines. These changes have been kept for 3 months with a tendency to increasing of intracellular cooperation and IF-γ synthesis.Summary: In patients effectively treated with botulinum toxin injections there are different immune changes. It shows a physiological reaction of immune system to the introduction of heterogenous antigens.

Purpose: Immune status regard in conditions of endemic goiter (IG) among the children of Alania.Materials and methods: 1198 schoolchildren were investigated (13-16 years old). The experiment group was determined(73 members) - schoolchildren with IG; control group was determined (41 members) - healthy teenagers. The data of numericaldistribution of general immunopathological syndromes was received. The investigations of interferon status and cytokines(IL-2, IL-4) were held by method of immune-enzymatic analysis in blood serosity by “Cytokine” kits. The results were regardedby Student criterion, Mann-Whitney-Wilcoxson criterion.Results: it had been revealed that 27,5% of schoolchildren with IG had clinical appearances of immune system dysfunction.In experiment group, in comparison with control group, it was determined accurate elevation of leukocyte’s ability to producegamma interferon (IF-γ): (25,3±1,2 against 10,7±1,6 (р < 0,005)) and alpha interferon (IF-α)(32,9±2,1 against 21,5±3,7(р < 0,02)). Was revealed an accurate decrement of IL-2 contain among the members of experiment group and accurate higherlevel of IL-4 than in control group.Summary: the results of investigation are filling up contemporary application about goitrousendemia in North-Ossetia Alaniaand might serve a foundation for development of patogenetically valid methods of treatment and prevention of IDC.

Purpose: To make a careful study particularities of the hormonal system by the vulvovaginities of often being ill girls in the period of senior preschool ages.Materials and methods. For the reason studies clinical and functional particularities of the reproductal system, authors examined 90 frequently sick girls with the vulvovaginities aged 3-6 years old. The control group had 30 practycaly healsy girls the same age with normal physical and sexual development.Results. It was determined that the frequently sick girls with the vulvovaginities had different exchange of hormonal status. Summary: In was determined that the frequently sick girls with the vulvovaginities had different breaches of hormonal statusand reproductal exchange.

Purpose: To improve the esophagoplasty results in children with esophageal atresia by the new method of abdominal colo- esophageal anastomosis.Materials and methods: A new way of using an abdominal esophageal part as a part of artificial esophagus in case of colic esophagoplasty was developed and applied in 16 patients with esopha-geal atresia. Before it all the children were undergone the double esophagostomy according to G.A. Bairov. The abdominal anastomosis was performed by seeming in the end of the colon graft to the lateral part of the esophageal abdominal segment.Results: The X-ray examenation of the new-made esophagus showed a good and an excellent food- passing function of the new esophagus in all the patients during the prolonged observation.Summary: Using of the abdominal esophageal segment as a part of artificial colon esophagus must be considered a fundamentally new method to provide for an antireflux protection of the graft, because of the natural esophageal antireflux mehanism, so the special antireflux operations can be excluded.

Purpose. To evaluate the diagnostic value of X-ray Wangensteen examination in case of rectal atresia in newborns.Materials and Methods. 27 newborns were examined: with a simple form atresia (11), with a rectovestibular fistula (9) andwith rectoperineal fistula (7). In all cases Wangensteen X-ray examination was applied.Results. In 15% of cases Wangensteen examination failed to diagnose the level of rectal atresia. In cases of rectal atresia’sassociation with rectovestibular and rectoperineal fistulas, authors suggest to replace Wangensteen examination with irrigography, after fistula’s bouginage and meconium releasing from rectum. Such an examination shows an absolutely true signs of atresia’slevel, so the surgeon can choose an appropriate surgical method of atresia’s treatment.Conclusion. In rectal atresia diagnostics X-ray Wangensteen examination showed false results in 15% of cases. In the presenceof low fistula types of atresia it’s rational to begin the treatment from fistula’s dilation by bouginage and following trans-fistulairrigography.

Purpose: to improve results of treatment of patients with the widespread peritonitis, complicated by a macrophage liver failure and endotoxicosis.Materials and methods: this paper is based on the analysis of clinical, instrumental and laboratory examination, medical supervision as well as treatment of 244 patients with disseminated purulent peritonitis (DPR).Results: it was indicated that treatment of the this patients with DPR shall be carried out using a complex of advanced medical technologies, which comprise adequate operational manual, initial empirical antimicrobial therapy, aimed at neutralizing the whole range of pathogenic flora (both aerobic and anaerobic) and intracorporal detoxification (nasointestinal intubation, intestinal lavage, enterosorption, early enteral nutrition, intraportal infusion).Summary: the research revealed that the principal part of fighting endotoxemia and macrophage liver failure belong to measures, preventing translocation of symbiont flora and toxins from the intestine into the portal blood flow and internal environment of the patient

Purpose: To improve the results of surgical treatment of patients with combined (multi-storied) occlusions, stenosis and thrombosis of the femoro-popliteal arterial segment by introducing a new method of reconstruction.Materials and Methods: 278 case histories were compared. Compared two types of reconstructive surgery: autovenous femoropopliteal bypass and extended endarterectomy.Results: In the earlier postoperative period the extended endarterectomy method allows you to get a positive result in 93,8% of observations, femoropopliteal and femoro-femoral bypass allows you to get a similar result in 81,2% of cases. In the late postoperative period endarterectomy can save 87,5% of the operated limbs, the thrombosis of superficial femoral artery was18,8%, and 78,8% in cases of autovenous bypass, the thrombosis of bypass in 57,6% of cases.Summary: The technique of extended endarterectomy allows to restore circulation in its entirety and this method is theoperation of choice. When performing an extended endarterectomy we save the bloodstream through the own arterial channel,preserving functioning collaterals. In the cases of thrombosis of the superficial femoral artery we rarely need to perform anamputation of the limb.

Purpose: To study the intensity of glycolysis and antioxidant system (AOS) in patients with varying clinical course of high myopia.Material and methods: The examination of 3 groups of patients, from 15 to 27 years old: the 1st group - those with fast- progressive high myopia, the 2nd group - those with slowly-progressive high myopia and the 3rd (control) group.Results: Has revealed the increased level of lactic acid and pyruvic acid combined with the decreased activity of antioxidant system in the lachrymal fluid.Summary: The combination of such indices as the increase of hypoxia ratio by more than 1.0 and the decrease of superoxide dismutase content in the lachrymal fluid by more than 40% can serve a prognostic criterion of glaucoma development with the persons suffering from fast-progressive high myopia.

Purpose: To estimate the efficiency of test using Diaskintest preparation for tubercular infection’s identification and an opportunity of it’s usage in decision the problem of preventive tubercular therapy.Materials and methods: There have been included 220 children and teenagers in the research.Results: Of the total number of children, 92 patients with positive reaction to Mantu test Манту with 2 TE PPD-L and negativereaction to the test with Diaskintest preparation have been recognized infected with MBT. 79 person had positive results of theboth tests. 40 person of this number had an active tuberculosis, 2 - inactive changes, and among 25 person - tuberculosis datahas not been revealed. 10 person had negative results of the both tests. 117 patients have been recognized infected with MBT,however children with PM+DT (92 people.) did not require usage of the preventive therapies, and 25 patients with PM+DTrequired usage of the preventive therapies in connection with presence of a latent tubercular infection.Summary: There has been shown the efficiency of Diaskintest preparation in diagnostics of an active and latent tubercularinfection and an opportunity of it’s usage as an indicator of high risk of an active tuberculosis development while decision thequestion on the necessity of the preventive therapy usage.

We present a case of superficial disseminated actinic porokeratosis in a 56-year-old male patient. Clinical and laboratory criteria of the disease and approaches to its treatment are discussed in the article.