Data from various references about features of a current limited склеродермии (OS) is presented interfaced. The hypothesis that OS and system scleroderma (SSD) represent versions of one pathological process that proves to be true presence an one-orientation of metabolic shifts, a generality skin changes at both forms of illness, and also cases of transformation of the localised process in a progressing system sclerosis Is discussed. Frequency of occurrence, prevalence of those or other forms of OS, longevity of patients, clinical displays and duration of a current of OS and its communication with other pathological processes is discussed. Various schemes of treatment of OS which have multicourse and multicomponent character are considered.

In the review are cited the given literatures on superficial and deep veins of the lower limbs. Sources, topography and places of a confluence of these veins are considered. The arrangement of the basic veins is illustrated. Data about possible variants and anomalies of superficial and deep veins are presented. The special attention is given to perforating veins.

The basic principles of the diagnostic and treatment of patients with rheumatoid arthritis (RA) has changed in recent years. Last clinical guidelines recommended the initiation of therapy with biologic agents (BA) as early as it possible, however the patient population with RA has heterogeneity of clinical progression. In present review authors analyzed the basic prognostic factors (clinical, immunological, radiological, genetic) that can predict clinical outcomes also in patients with BA therapy.

There are represented the role of sleep for normal activity of human organism, consequences of sleep disorders for health in this review We have taken a close look at such widespread type of a sleep disorder as insomnia and described the most perspective approaches to non-pharmacologic management of primary and secondary insomnias. We have also paid attention to large efficiency of such methods.

Purpose: To reveal, what changes of fibers of a pattern of urine at sick are connected by a chronic heart failure (CHF) with increase of a functional class (FC) of disease.

Materials and Methods: 90 patients with CHF II-IV FC are surveyed. Control group practically healthy 30 patients. Differentiated allocation separate proteins and fibers of urine of patients made by means of weights-spectrometry.

Results: At patients CHF in structure of fibers of urine markers of alteration of kidneys, connected with structural transformation. Progressing CHF up to a final stage it is connected with increase of occurrence β-sarcoglican, similar to tolloids fiber 2 and L-antigen. Among contracting fibers in process of increase FC CHFoccurrence cation-transport ATP decreases, and isoforms 1 fiber 6, connected with microtubuls – raises, that causes reduction of activity of receipt of calcium in sarcoplasmic rethiculum in nephrocytes and endoteliocytes vessels of kidneys.

Summary: Changes of an albuminous spectrum of urine at patients CHF it is information are significant for the forecast of progressing of a basic disease.

Purpose: To study of relationship between somatotypes, dermatoglyphical parameters in medical students with gastrointestinal tract disturbances. Had been studied 92 students (55 females and 37 males) with gastrointestinal tract disturbances.

Material and Methods: Metrical method of somatityping, palmoscopy (size of the basic flexor furrows of palms, character of disturbances furrows, size of basic palm angle АtD). The metric scheme of somatotype measurement, the data palmoscopy (length of the basic flexors palm furrows, character of their infringements, size main palm angle АtD) was used.

Results: Diseases of digestive organs most often meet at MaMeS and MaS somatotypes of men and women, character of infringements flexors furrows of a palm at them is presented by plugs and the increase main palm corner АtD is marked.

Summary: Between parametres palmoscopy and somatotypes of patients with diseases of digestive organs have a close connection that it is necessary to consider at medico-genetic inspections of the population.

Purpose: To study the clinical efficacy of cytoflavin and extracorporeal immunoprophylaxis with RoncoleukinR in preventing septico-pyogenic complications in coloprotological cancer patients.

Materials and Methods: In a prospective controlled study, we investigated 214 patients, who had been operated for colorectal cancer. Preoperatively we studied the following indicators: T lymphocytes (CD3, CD4, CD8), B lymphocytes (CD72) and IgA, IgM, IgG; cytokine profile: IL-1, IL-4, IL-6, IL-1β, TNF-α, IL-8, IL-ra; as well as the following systems: peroxide oxidation of lipids (POL) and antioxidant systems: MDA, superoxide dismutase (SOD), GPD and GAA of blood serum. In the group under investigation, in addition to comprehensive intensive therapy we added adoptive immunotherapy using human interleukin 2 together with the antioxidant cytoflavin.

Results: The described method of treatment of colorectal cancer patients allowed us to restore the immune status as well as neutralise the disbalance in the system of free radical oxidation of lipids and restore antioxidant status.

Summary: With the use of RoncoleukinR and citoflavin the number of postoperative complications reduced by 2.1 times leading further to a reduction in mortality by 2.5 times when compared to the group that received the usual treatment.

Purpose: To estimate efficiency of work of the specialized reception of pregnant with an immunological conflict.

Materials and Methods: The analysis of flow of pregnancy is conducted, births, ends for a fruit in 5- ti clinical groups. A dynamic supervision was conducted, a title was determined groups and anti-rezusnykh antibodies, ULTRASONIC, dopplerometriya fruit.

Results: In all 21659 children borned in all clinical groups, at the 1377 (6,4%) new-born was GB is diagnosed.

Summary: The got results confirmed efficiency of work of the specialized reception, that allowed to reduce morbidity ot gemoliticheskoy illness in 6 times.

Purpose: Estimation of application efficiency of preparation «Striks» in complex myopia treatment for the children of school age.

Materials and Methods: There were 77 children under a supervision parted on 3 groups. In basic groups 1 and 2 patients got medicinal therapy including «Striks» for to a 1 pill 2 times per a day, course 2 months. Monitoring of all children passed during 6 months.

Results: The sharpness of sight on a background treatment of «Striks» in the group 1 rose on 71,6%, in the group 2 on in 62%, reserve of accommodation rose in the group 1 on 78,6 %, and in the group 2 on 75%. In a control group in times of supervision the sharpness of sight went down and reserve of accommodation diminished.

Summary: Application in complex treatment of making progress miopii for the children of biologically active food addition «Striks» positively influences on the accommodation vehicle of eye and sharpness of sight.

Purpose: To spend an estimation of parities between the maintenance fenibut in plasma of blood and a brain of rats and its maintenance in a placenta and an organism of embryos of rats.

Materials and Methods: Experimental researches are spent on 124 pregnant females of rats. The preparation was entered in a stomach, unitary in doses of weight of an animal by of 100 and 200 mg/kg. Through 5, 10, 20, 40 mines, 1 h 20 min, 2 h 40 min., 6 and 12 hours after preparation introduction took samples of blood, a brain, a placenta, an embryos and waters about an embryo.

Results: The maximum concentration fenibut in all bodies and fabrics is reached on 40 minute, then throughout 6 hours stable level of a preparation with constant smooth decrease is observed that quite arranges obstetrics clinic as in the course of regulation of the patrimonial certificate are especially important stability, duration and absence of sharp jumps in concentration of a preparation.

Summary: The preparation greatest quantity concentrates in the basic body of the appendix – a brain. The least quantity fenibut gets to an embryo. The obtained data confirms expediency of use fenibut in obstetrics clinic.

Purpose: To determine the main trait of kidney’s blood supply of the representatives of five vertebrates (including people), to study blood supply sources, to estimate adaptation reorganization of intraorgan kidney’s arterial race and the juxtamedullary way of the blood-groove.

Materials and Methods: 484 kidneys of representatives of five classes of vertebrate animals and 400 kidneys of people of various ages are investigated. The complex of morphological research methods was used.

Results: Qualitative and quantitative characteristics arterial vessels in rather-anatomic, age aspect are received, and also at cardiovascular diseases.

Summary: These data have allowed estimating adaptable reorganization of an arterial channel of kidneys and juxtamedullary shunt.

Purpose: In order to improve the follow-up results of the treatment of patients with anal fissures a complex therapeutic approach was suggested and a number of criteria defining the choice of management methods were worked out.

Materials and Methods: 387 clinical cases with acute and chronic anal fissures were examined, treated and analyzed in retrospect.

Results: Fissures were healed in 93,3% of patients. It proved that a differential approach to the choice of the method of treatment of patients with anal fissures allows to improve the functional results. A calibrated sphincterotomy is a necessary component of the surgical management of anal fissures in case of the sphincter hypertone. The original method of modified sphincterotomy (Patent RF #2293529) ensures the necessary conditions for a speedy recovery of operative wounds and an early rehabilitation of patients.

Purpose: Estimation of free radicals oxidation and antioxidant status of «moter-placenta-foetus» functional sestem at physiological and complicated by cardiovascular pathology pregnancy.

Materials and Methods: Erythrocytes and homogenates of placenta tissue taken from 75 pregnant was chosen as material for our investigation. There were estimated the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, the concentration of malondialdehyde, reduced glutathione.

Results: It was estalished that pregnansy compicated by cardiiovacsular pathology was characterized by oxidative stress and disorder of different type of placental tissue metabolic activity/Summary: Estimation of these rates can be used in obstetrics and gynecology for the fetoplacental insufficiency severity degree.

The patient C. initially had normal numbers of blood pressure, and even observed a tendency to hypotension with increased many times the level of aldosterone, which is atypical for a picture of primary hyperaldosteronism, since this disease is characterized by 100% of the high numbers of blood pressure caused by the action of aldosterone. But initially unwarranted patient survey led to the removal of healthy adrenal gland, which ultimately was not accompanied by normalization of the level of aldosterone. In Rostov-on-Don city endocrinology center in accordance with the standards of diagnosis and treatment of primary hyperaldosteronism held orthostatic test, which showed an adequate adrenal response to a change in body position, made the assumption that increased numbers of aldosterone are individual character, and the patient’s further treatment the patient С. does not need.

The article analyzes Prof. M.G. Chernyahovski’s ideas: the role of general surgery in the training of doctors of various specialties, the need by the surgeon to know the pathogenesis of human illness, the original name of surgery: «therapeutical surgery» that the surgeon should not only remove organs but also treat the patient.