The objective was to assess clinical and anamnestic indicators and characteristics of blood erythrocytes in newborns according to the severity of anemia. Materials and methods: we examined the 65 case records of newborns with anemia who received medical treatment in pathology department of Rostov Research Institute of Obstetrics and Pediatrics from November, 2015 to March, 2016. All newborns were divided into 3 groups depending on the severity of anemia: I group included 40 newborns with mild case of anemia, II group – 8 infants with medium-heavy anemia, III group – 17 newborns with heavy extent of disease. Results. The most common risk factors of severe anemia on the distaff side are obesity (35.3%), anemia (100%), threatened miscarriage (65,%), cytomegalovirus infection (41%), gestational diabetes (or 41.2%). Conclusion: The risk factors of anemia in newborns are unfavorable for the antenatal period complicated by anemia, threatened miscarriage, gestational diabetes mellitus, cytomegalovirus infection, presence of respiratory distress syndrome, cerebral ischemia II degree in combination with hemolytic disease of the newborn.

Objective: to study the possibility of visual functions ant condition of higher nervous activity of children with amblyopia with the method of transcranial  direct current stimulation during drug treatment. Materials and methods: 32 healthy children in the age of 5-12 years and 97 patients of the same age with refractive amblyopia were screened. Research methods: standard ophthalmological - visometry, refraktometry in normal conditions and in cycloplegia, biomicroscopy of eye, ophthalmoscopy, definition of vision character; neurophysiological methods - latency period of parameters of visual evoked potential, electroencephalography with аmplitude definition; alpha – rhythm frequency; slow waves, locating peak electrical activity area of the cerebral cortex; assessment of neuropsychic state of the patients, including mental development scaling (MDS) by mental age tests. Results: proposed treatment enhances neurophysiological measures of the visual sensory system in 83.5% of all cases and visual acuity in 81,4% of all cases, the state of higher nervous activity closer to the physiological norm at 86.6%. Conclusion: the results of these examinations have confirmed a neurophysiological direction of the new treatment method with use of transcranial direct current stimulation. It has observed that the patients from the age of 5-6 have had the maximum clinical effect so it has been recommended to hold amblyopia treatment in preschool age. Due to the significant improvement of patients’ mental development coefficient, improvement of memory, logical thinking, adaptation in collective transcranial direct current stimulation treatment method of children with amblyopia has a social protection in the Russian Federation.

The objective was to assess risk of acute bronchitis due to the use of the split-system. Materials and methods: Data were collected at the healthcare districts covered by the outpatient department of the 4th City Hospital of Sevastopol. Results: The use of the split-system without regular cleaning is a risk factor for health, which is associated with a 3.5-fold increase of the incidence of acute bronchitis. Regular cleaning of the split-system decreases risk of acute bronchitis to the level comparable to that of subjects who do not use an air conditioning system. Conclusion: Measures for regular cleaning of the split-system are recommended to manage risk of acute bronchitis.

Objective: to study bone mineral density indexes in zone of L1-L4 lumbar vertebrae and left and right femur proximal departments including left and right femoral necks in postmenopausal women according to genotypes of -1997 C>A polymorphism of COL1A1 gene. Materials and methods: 483 Caucasian women from eastern and central regions of Ukraine were examined. All women were postmenopausal. Osteodensitometry was carried out by dual-energy X-ray absorptiometry method. Detection of a gene COL1A1 -1997 C>A polymorphism was carried out by the real-time PCR method. Results: it was established that the low bone mineral density indicators in zone of left femoral neck were associated with AA genotype (Р=0,040), and in zone of right femoral neck and proximal department – with AA and CA genotypes (Р=0,008-P=0,035). Association of polymorphic variations of COL1A1 gene (-1997 C>A) with mineral density of L1-L4 lumbar vertebrae was not established. Conclusion: the obtained data can be used for detection of predisposition to postmenopausal osteoporosis development and increase of treatment-and-prophylactic actions effectiveness.

Purpose: to evaluate the impact of stenting of the pancreatic duct on the course of biliary pancreatitis for patients with impacted stone of major duodenal papilla.

Materials and methods: A retrospective analysis of the treatment of 90 patients with impacted stone of major duodenal papilla that underwent endoscopic interventions on the major duodenal papilla in 1/3 of cases accompanied by the installation of a stent of the pancreatic duct. Depending on the stenting, the patients were divided into two groups - the first group (n = 31 patients) with the stented pancreatic duct, the second group (n = 59 patients) - without stent placement. The groups were compared by the dynamics of changes and the normalization time of laboratory indicators, sonographic signs of biliary and pancreatic hypertension before and after the intervention.

Results: Following differences were observed: in the group of stented patients the hyperamylasemia has reduced with the period of normalization of amylase 1.5 times less (p = 0.005) , decrease of amylase at the stented patients with signs of pancreaticectasia at ERCP by 55.6% comparing to the patients without stent - 7.1% (p = 0.005). Laboratory signs of development of post-ERCP pancreatitis were noted in 6.5% of stented and 11.9% of non-stented patients. The average hospitalization time in the first group was 11.5 ± 4.1 days and in the second - 15.5 ± 9.6 days (p = 0.032).

Conclusion: Stenting the pancreatic duct in patients with impacted stone of major duodenal papilla reduces the risk of postmanipulation pancreatitis, speeds up the normalization of laboratory markers of acute biliary pancreatitis, reduces the time of hospitalization of this category of patients, has not only a preventive but also therapeutic effect.

Objective: This work was to estimate the influence of antibodies to human glycoprotein CD4 and IFN-γ on the T-cell immunity and the cytokine levels in patients with HIV and HIV/HCV during the standard antiretroviral therapy. Materials and methods: Randomized clinical trial in parallel groups. 4 groups were included: patients with HIV receiving ART (20) or ART and antibodies (AB) (19) for 3 months; patients with HIV/HCV, receiving ART (17) or ART and AB (20) for 3 months. The obtained data included: CD3+, CD4+, CD8+ cell count; IFN-γ, IL-2 and IL-4 concentrations; HIV viral load. Results: The significant increase of CD4+ cell number and IFN-γ were found in patients receiving ART and antibodies. These changes were followed with more significant decline in the viral load. Conclusion: The antibodies to human glycoprotein CD4 and IFN-γ added to standard ART increased the CD4+ cell count and IFN-γ levels in patients with HIV/HCV, followed by the trend to increase the number of patients with viral load >50 ml-1. Thus, the administration of ART supplemented with antibodies to human glycoprotein CD4 and IFN-γ resulted in the increase of antiviral immunity. Further clinical trials in HIV or HIV patients with co-infections could be recommended.

Objective: to assess the impact of the methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide medication on the free-radical oxidation processes and the possibility of its use as a multifunctional mean of pathogenetic tuberculosis therapy. Material and methods: a comparative analysis of treatment efficiency, clinic-laboratory data, and free-radical oxidation indices of 50 patients with active pulmonary tuberculosis, which obtained methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide and a standard pathogenetic therapy, was carried out. Results: a decrease in the frequency and severity of destruction of lung tissue, the cessation of bacterial release, rapid resolution of infiltration in the lung tissue, which was accompanied by the normalization of the parameters of the antioxidant protection system, was revealed under the influence of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide. Conclusions: the use of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide as a pathogenetic medication for patients, who received antituberculosis treatment, results in substantial positive clinic-laboratory dynamics, increase of treatment efficiency, and normalization of free-radical oxidation indices in comparison with those, who received standard pathogenetic therapy.

The aim was to study papillary muscles of the right ventricular septomarginal trabecula. Materials and methods: 98 formalinfixed normal hearts from human fetuses aged 17 to 28 weeks were studied by means stereomicroscope. Results. Muscles in such position were found to be in 55.1%. The free-standing papillary muscles predominated over the muscles of fixe type. The muscles had monolithic base, one belly and mostly one apex. Tendinous chords of these muscles entered only the septal cusp of the right atrioventricular valve. A potential clinical importance of the papillary muscles was mentioned. Conclusion. The papillary muscles situated at the septomarginal trabecula are proposed to regard as particular subgroup of septal papillary muscles.

The increase of lifetime and the relative improvement of individual health indicators generally have not yet led to a balance of health among the populations of different countries and individual population groups. Health indicators differ between different population groups in all countries. At the same time, the level of health depends on many factors and environmental conditions, as well as on the individual lifestyle. Socioeconomic determinants that have the greatest impact on the formation of human health are amenable to adjustment at the state level. It should be noted that the role for each of the determinants in shaping health is not the same, and the determinants themselves may be different for population groups and countries. This is particularly important for the definition of differential health indicators, the use of which in public policy will reduce the differences in health status within each country and between countries.

Objective is to improve outcomes of treatment of patients with opisthenar burns by optimizing the algorithm of care. Materials and methods: 272 victims with local deep opisthenar burns were analyzed. Results: the study showed an advantage of the method of early surgical treatment of opisthenar burns before the landmark treatment of these burns. Patients operated on by early necrectomy with plastic without perforations have the best immediate and long-term results of treatment. Conclusion: the use of active surgical tactics including the removal in the early period (1-3 days after injury) burn eschar with simultaneous plasty of wound non-perforated skin graft performed under tourniquet followed by the imposition of a pressure bandage is the method of choice. This approach helps prevent the development of rough scar contractures and deformities in the postoperative period and achieve good cosmetic results.

The article is dedicated to the peculiarities and the development trends of the provision of high technology medical help to patients with deforming arthrosis of large joints in Rostov region. Conservative treatment of these diseases is not effective and doesn’t give desired results. Only high-qualified doctors specially trained in the field of joint surgery should perform surgical treatment of such diseases. Significant change in state financial policy has made it possible to provide medical treatment to a greater number of such patients.

In modern conditions the success of a medical institution is determined by its competitiveness. The differences between organizations in terms of medical technology development, technical capabilities and experience of the specialists tend to be aligned. To the fore as key factors of competitiveness overlook – the effectiveness of the actual commercial activities of the organization and efficiency of management decision-making.

The combination of various features and functions of medical information system allow you to use the base system to manage medical records, optimize the movement of patients and booting diagnostic and treatment facilities, and to obtain operational data in support of management decision-making and to improve the efficiency of commercial activities of companies.

Clinical observation of a hyperplasia of the adrenal cortex in the newborn is presented. Main feature of this observation is the complicated course of this disease in the newborn against hypoxemic defeat of the central nervous system and neonatal jaundice. Now treatment of this congenital disease has to begin with the first week of life and includes complete hormonal and infusion therapy. In this observation child’s clinical improvement is noted.