In the literature review presents the current information about pregnancy and childbirth in women with arterial hypertension. Discusses the influence of cardiovascular disease on programically period, childbirth and the health of newborn children in this cohort of patients. Emphasizes the need for careful monitoring of both before pregnancy and during the last.

Using biological modelling it is possible to study in detail the pathophysiological mechanisms for the development of obstetric pathology and develop pathogenetic methods of correction.

Review presents pathogenetic basis of electrical instability of the heart in hypertensive patients with diabetes mellitus – fundamental cause of fatal ventricular tachyarrhythmias and sudden arrhythmic death.

Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.

Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of glutathione and glutathione peroxidase enzyme activity, glutathione-S-transferase, glutathione reductase in the erythrocyte hemolysate, liver homogenates and cardiac muscle have been determined.

Results: it has been found that in the animals with experimental hyperhomocysteinemia and musculoskeletal injury the liver and erythrocyte glutathione system components react.

Conclusions: an increase of glutathione content and activity change of glutathione peroxidase, glutathione-S-transferase and glutathione reductase in different tissues have been shown.

Purpose: identification of new mechanisms of the development of generalized herpes virus infection (current cytomegalovirus infections and infections caused HSV1,2 types) in newborns.
Materials and Мethods: the data reviewed 69 newborns with generalized herpes virus infection in the early neonatal period. I group (n=47) amounted to children with generalized cytomegalovirus infection. In the second group (n=22) were included
children with generalized form of the infection caused by the herpes virus 1,2 type. The control group consisted of 26 healthy newborns. The definition of the expression of TLR-2(СD14+СD282+) and TLR-6(СD14+СD286) on monocytes conducted by laser flow cytofluorometry (Beckman Coulter, USA). Polymorphism of allelic variants of genes TLR studied by PCR and subsequent restriction fragments length polymorphism analysis test systems for molecular genetic analysis, Moscow.
Results: the decrease of expression of TLR-2 and TLR-6 has a place in generalized the current cytomegalovirus infections in children and adults with complete clinical symptoms. Newborns with severe herpes infection, there is a decrease in the expression
of TLR-thefact in the genes TLR are identified by 68.4 % of children with generalized the current cytomegalovirus infections with full clinical symptoms in the form of polymorphism Ser249Pro gene TLR-6 and 26.3% of children with severe herpes infection in the form of polymorphism Arg753Gln gene TLR-2.
Summary: the new data confirm the role of immune system in the pathogenesis of generalized herpes infection. It is established, that in children with congenital generalized herpes virus infection leading to the formation of an immune response is a breach in the system of factors of innate immunity.

Purpose: to study the anatomical and functional characteristics of different functional units of the «mother-placenta-fetus» system in the dynamics of physiological pregnancy, taking into account the ethnicity of women.

Materials and Methods: a prospective longitudinal study of morphological and functional state of the mothers’ organisms and their fetuses of Russian, Chechen and Ingush nationalities in the dynamics of physiological pregnancy.

Results: we revealed statistically significant differences in morphometric parameters, hormonal status of the maternal organism, as well as in the rates of growth of the fetuses, defined by ethnicity.

Summary: these results indicate the need for the development of individual regional standards for obstetric ultrasound screening. Representatives of Caucasian nationalities have higher risks for the development of the metabolic syndrome.

Purpose: to evaluate the rate and severity of filtration renal dysfunction in patients with acute coronary syndrome after percutaneous coronary intervention (PCI) with X-ray contrast.

Materials and Methods: serum creatinine levels were collected from 71 patients twice, before the introduction of the contrast agent and 3 days.

Resuls: in 56.9% of cases was recorded worsening renal function, and in 37.3% diagnosed the incidence of contrast-induced nephropathy (CIN), defined as a rise in serum creatinine level by 25% or more.

Summary: because at the time of admission to the hospital, a physician still does not have enough reliable criteria for evaluating the risk of CIN, a preventive measures for improving renal function have to be included in the complex treatment of patients who are receiving the radiocontrast agent. Regardless of the severity of patients’ condition and the presence of concomitant chronic diseases.

Purpose: to establish efficiency of enteral protection therapy in correction of a syndrome of endogenic intoxication at acute peritonitis.

Materials and methods: pilot studies on dogs (n=32) and clinical observations (n=46) are the basis for work. The acute purulent fibrinous peritonitis was modelled. After operation in dynamics series of biophysical and biochemical indicators of intestine structures, markers of endogenic intoxication were studied at the organ and organism levels.

Results: it is established that in development of endogenic intoxication syndrome at acute peritonitis the important role belongs to an enteral failure owing to membrane destruction phenomena because there were excessive intensity of lipids peroxidation, increased phospholipase activity and a hypoxia. The Remaksolum was effective in correction of an enteral failure and, as a result, in cupping of endogenic intoxication. Clinical and laboratory researches confirmed Remaksolum efficiency in cupping of endogenic intoxication at patients with acute peritonitis.

Summary: in the development of enteral insufficiency syndrome in acute peritonitis play a key role membranodestabiliziruyuschie phenomenon due to the high intensity of lipid peroxidation, increased phospholipase activity and hypoxia. Application remaxol in the early postoperative period pathogenetically substantiated and clinically advisable to correct the endogenous intoxication in acute peritonitis. The drug, possessing antioxidant, antihypoxic, fosfolipazdepres-sive action leads to stabilization of the phospholipid bilayer of cell membranes ki shechnika reduces the negative aspects of enteric disease.

purpose: оn the base of complex morpho-pharmacological analysis to evaluate nootropics and its combinations with melaxen effects in rats experimental acute cerebral ischemia.

materials and methods: morphological (light-, electron microscopic and morphometric) analysis of the experimental material

(frontal cortex and hippocampus) and lethality was studied on 21 white rats with induced by the ligation of bilateral common carotid arteries of acute cerebral ischemia and used a preventive course of nootropics (vinpocetine, piracetam) and melaxen.

results: it was established that preventive combined vinpocetine and melaxen usage significantly reduces rat’s lethality and brain ischemic damage degree, indicating obvious neuroprotective activity.

summary: the results obtained indicate significant potential importance of melatonin-based drugs usage for neuroprotection therapy emprovement in cerebral ischemia.

Purpose: detects changes in proteomic spectrum of placenta at the complicated pregnancy.

Materials and methods: 52 women are examined, of which the first group consisted of 15 women with uncomplicated pregnancy, the second - 19 women with fetal growth retardation (FGR), the third group consisted of 18 patients whose pregnancy was complicated by pre-eclampsia. Proteomic analysis of the placenta was performed using two-dimensional electrophoresis and time-of-flight mass spectrometry.

Results: the conducted researches allowed to detect and identify proteins, the intensity of which production in complicated pregnancy is significantly different from that in physiological pregnancy. Comparative proteomic analysis of proteomic spectrum of placenta of women with FGR and preeclampsia also found intergroup differences.

Summary: the revealed changes in the proteomic composition, obviously, reflect disturbances of molecular and cellular interactions in the placenta and have pathogenetic importance in formation of complicated pregnancy. The specifics of development of obstetric pathology may to some extent depend on differences proteomic spectrum.

Purpose: the aim of the study was to improve the results of treatment of the full-term babies with SDR and cerebral ischemia, being on AVL, connected with a decrease of the incidence of bacterial complications, by using sodium selenite pentahydrate.

Materials and methods: controlled randomized blind clinical test of application of sodium selenite pentahydrate at newborns with RDS and the cerebral ischemia being on the artificial ventilation of lungs (AVL) was carried out. 76 newborn children being in a critical condition were surveyed. Randomization was carried out by a method of the computer program of a random number generator. In I group (n=36), entered sodium selenite pentahydrate in a dose of 10 mkg/kg/days intravenously slowly, within 10 days, II group (n=40) – group of control.

Results: sepsis as a complication of the underlying disease, developed in 11 (14,5%) patients from 76 patients included in the study. Moreover, in group I (treated by selenase) sepsis occurred in 2 (5,5%) infants, while in group two II, in 9 (22,5%) patients.

Summary: thus, in our study conclusive, statistically significant evidence was obtained that, using sodium selenite pentahydrate is not only a significant decrease (4.5-fold) (p < 0.05).

RETRACTED

Purpose: to determine the role of intraluminal ultrasonography with dopplerography in estimation of intestinal wall’s changes in patients with stomas and to establish the terms for restorative operation.

Materials and methods: results of intraluminal ultrasonography with dopplerography in 79 patients with stomas were studied. All patients were underwent radical surgery for left sided colon cancer complicated by acute intestinal obstruction.

Results: use of method of intraluminal ultrasound dopplerography enabled to determine terms for restorative operations beginning from the 4th week. At this time blood peak flow in the intestinal wall achieves 10,45±0,92 sm/s and thickness of the adducting intestinal wall becomes 0,18±0,02sm. Since the proposed diagnostic and treatment methods were taken up in our clinical practice the period of complete rehabilitation was reduced from 7 to 5,31 months in patients with terminal stoma and from 6,15 to 2,6 months in patients with loop stoma. Frequency of postoperative complications was reduced from 32,9 to 15,5%, statistically significant.

Purpose: explore the features of the structure and volume of combined fatal injuries, the frequency of morphological manifestations shake the body in children in cases of falls from a height.

Materials and Methods: results of forensic investigations of corpses of 147 children and 110 adults, who dead by falling from considerable height were analyzed.

Results: comparative study of the lesions, detected by autopsy in children with concomitant injuries showed their less severity than in adults. They were manifested by lower frequency of multiple lesions.

Summary: nevertheless, such types of injuries as damages of fixing apparatus of thoracic and abdominal organs in children were registered more frequently than in adults.There were no revealed any significant differences in distribution of lesions of body regions in children and adults.

Purpose: studying microorganisms from condensate, formed in air-conditioning systems, and assessment the possibility of elevation of aerosol to the ≪breathing zone≫ of the person.

Materials and methods: sampling of condensate from air conditioning systems; isolation of pure strains and his identification; modeling situation, when from split system, located on the second floor, streamed condensate with conditionally pathogenic bacteria.

Results: in condensate, formed in air-conditioning systems, conditionally pathogenic microflora families Enterobacteriaceae and Pseudomonadaceae, Staphylococcus aureus and Burkholderia cepacia founded. The experiment showed that fall of condensate drops on a solid surface formed aerosol. This aerosol contain microorganisms from condensate and can lifted by airflow at a height of 1.5 meters, to the breathing zone of an adult person.

Summary: to reduce the risk of the condensate contamination by conditionally pathogenic microflora regular cleaning and disinfection of air conditioning systems needed. To protect the health of casual passer from bacteria-contained aerosol, need to remove the condensate from air-conditioning system directly into the sewer system.

Purpose: the aim of the study was to explore the features of humoral immunity in children 2-4 years with recurrent respiratory diseases attending organized children’s groups.

Materials and Methods: 158 children aged 2 to 4 years were examined. 126 patients suffered from recurrent respiratory diseases (basic group) and 32 healthy children (control group).

Results: the lowest serum levels of IgA and IgM were marked in children with recurrent respiratory diseases comparison with a group of healthy children (p<0.01). We have found in the study of factors of humoral immunity a positive correlation the levels of IgA with IgG (r=0,29, p<0,001) and IgE with IRI (r=0,24, p<0,01). An inverse correlation was also found between IgM to IgG (r=-0,37, p<0,001), and IgM to IgE (r=-0,16, p<0,05). Thus, correlative interrelations were determined in the patients of basic group, represented the disbalance of the immune system in children with RRD.

Summary: these changes were formed as a result of prolonged stimulation of the immune system and infectious agents and led to tensions of the processes of immune response and depletion of reserve capacity in children.

Purpose: develop optimal treatment of adolescent girls with AN and oligo-amenorrhea depending on the clinical features (typical and atypical HA), as well as the severity of psychopathology.

Materials and Мethods: I group - 22 patients with typical AN, II group - 18 patients with a diagnosis of atypical AN. The age of both groups 16 (18; 14) years. The body mass index I of group - 15,6 (17,5; 11,6), II - 14,55 (17,34; 10,2). Control group - 20 teenage girls. Conducted clinical-psychopathological, experimental psychological research, psychometric scaling.

Results: revealed differences in the treatment of typical and atypical AN, higher efficiency of treatment was found in patients with typical AN.

Summary: the results suggest the need to further study the effects of pharmacological therapies for the development of optimal treatment strategy of adolescent girls with AN and oligo-amenorrhea.

Purpose: the study of cytokine status in infants with perinatal CNS damage from mothers with placental insufficiency.

Materials and methods: were examined 95 newborns from mothers with chronic kidney disease. Control group – newborns from mothers with physiological pregnancy and childbirth(n = 19). The definition in the cord blood of newborns level of IL-6, TNF-alpha, IFN-g, IL-1β, IL-4 were performed by the method of enzyme immunoassay with the use of diagnostic kits “Cytokine”, St. Petersburg.

Results: for children from an early manifestation of perinatal Central nervous system from mothers with decompensated chronic kidney failure, by the increase in cord blood levels of IL-6, IL-1β, TNF-alpha , IFN-g, For children delayed manifestation of perinatal Central nervous system from mothers with asthma, chronic kidney failure, by the increase in the level of IL -6, TNFalpha, IL -4, IFN-g. For children, delayed manifestation of perinatal Central nervous system from mothers with compensated chronic kidney failure, by the increase in the level of IL -4, IFN-g, IL-6.

Summary: the development of perinatal CNS damage in newborns from mothers with chronic kidney disease associated with the violation of cytokine balance in cord blood, with a tendency to focus on Th1-type, which promotes the formation of inflammatory mode immune regulation.

RETRACTED

Purpose: to develop a system optimization sinus-lifting in diseases of the maxillary sinus by a one-step fix pathology sine and implementation of an open sinus lifting.

Materials and methods: 22 patients of the main group moved through the operation of an open sinus lift directly after prior endoscopic interventions on the maxillary sinus. 20 patients endonasal intervention on the maxillary sinus was performed for 2-6 months to open sinus lift. Comparing the results of different approaches to dental and endonasal procedures.

Results: domaintest perform dental and endonasal surgery is possible to eliminate the perforation membrane in the main group. In the control group this complication was detected in 3 (15%) patients. In the control group after sinus thickening of the mucous membrane of the maxillary sinus was observed in a larger number of patients (45% and 14,3%), the total duration of the two stages of the stationary period was almost 2 times longer with 3 times lengthened the period from surgical intervention to dental implantation.

Summary: domaintest perform dental and endonasal interventions with an open sinus lift, allows prevent perforation of the lining of the bottom of the maxillary sinus.

Purpose: to identify the diagnostic value of simultaneous determination of baseline concentrations of С-reactive protein (CRP) and interleukin-6 levels in the blood in patients as additional factors in assessing the risk of cardiovascular disease by screening by specifying the intensity of inflammation.

Materials and methods: screening to identify cardiovascular risk and the concentration in the blood CRP and interleukin-6 in 304 patients urban populations in the outpatient polyclinic inspection and survey.

Results: set pairing between the increased risk on a scale SCORE, and the concentration of CRP in the blood. Diagnostic level of CRP in the blood to separate the risk of cardiovascular disease at the lowest and the highest was 3 mg/l. a closer link was established between the number of risk factors and the studied marker of inflammation.

Summary: when screening risk assessment should be carried out in the cardiovascular disease with quantitative measurement of CRP in the blood concentrations of the base.

Purpose: to evaluate the performance of transplacental adaptive immunity to opportunistic bacteria in newborns.

Materials and Мethods: the study involved 682 newborn baby born to women 18-44 years old with various infectious anamnesis: weighed down (I group) and favorable infectious anamnesis (II group). Material for research is umbilical cord blood in that by linked immunosorbent analysis were determined IgG-antibody to opportunistic bacteria: S.aureus, S.epidermidis, S.pneumoniae, P.aerugonosa, E.coli, P.vulgaris, H.influenzae and K.pneumoniae.

Results: it is set that a range of mean values of antibodies to оpportunistic bacteria was 36,5-60,6 conventional units at all 682 inspected. Thus, for the children of I of group their range hesitated within the limits of 41,3-57,2 conventional units, in II to the group - 50,3-64,7 conventional units. Lower values detected antibodies only to two оpportunisticbacteria -S. pneumoniae and H. influenzae in children in I group as compared to group II infants. And their level was lower in the umbilical cord blood of newborns born to women over the age of 25-30 years.

Summary: the presence of infectious and inflammatory diseases in women during pregnancy, especially older than 25 years can be considered as a risk factor. This fact substantiates the need for the complex medical-diagnostic and preventive measures for the prevention of controlled infectious diseases caused by оpportunistic bacteria in the future in children.

Purpose: to analyze the relationship between iron metabolism and rhythm and conduction disorders in the children with acute lymphoblastic leukemia (ALL).

Materials and Мethods: the children were studied over time: at admission to the clinic before the start of chemotherapy (Group 1a), after remission induction (Group 1b), and after discontinuation of intensive polychemotherapy (Group 1c).

Results: examination of iron metabolism in the children with ALL revealed significantly elevated serum iron level with increased iron transferring saturation index, ferritin and hepcidin levels and lower total iron binding capacity (TIBC) at all stages of polychemotherapy (PCT). Summary: the children with ALL demonstrated significant association between serum iron level and nomotopic automatism disorders (sinus tachy-, brady, arrhythmias) at all PCT stages; between serum iron level and extrasystoles appearance during and after discontinuation of the treatment; and also between serum ferritin level and myocardial depolarization disorders at all PCT stages and conduction disorders during and after discontinuation of the treatment.

Purpose: to analyze the effectiveness of cerebral oximetry to optimize the oxygen concentration (FiO2) in the inspired mixture in the application of artificial ventilation (AV) and the influence of oxygen status on indicators of oxidative stress in newborns.

Materials and Methods: total of 75 neonates receiving mechanical ventilation. Patients of the main group (n = 38) modes of mechanical ventilation and FiO2 were determined under the control of cerebral oximetry. In the control group modes of mechanical ventilation and FiO2 were set according to the partial oxygen pressure in the capillary blood. All patients were determined peroxide oxidation products and protein in serum.

Results: f reduction in the duration of mechanical ventilation, the concentration FiO2, levels of markers of oxidative stress in patients in the study group.

Summary: cerebral oximetry during mechanical ventilation to optimize the oxygen status, reduce the risk of oxidative stress in newborns in critical conditions.

Purpose: To evaluate the effect of different treatment options preeclampsia (PE) on renal dysfunction in women with alimentary obesity (AO) before delivery.

Materials and Methods: A randomized study of 63 pregnant women with PE and AO. The average age - 27,4 Ѓ} 1,6 years. The first group - 31 women who underwent conventional therapy. The second - 32 women, therapy provides for the correction of renal dysfunction. Examined leptin, renin-angiotensin system (RAAS), VNS, adaptation circulation, kidney function.

Results: The high concentration of leptin activation of the RAAS, endothelial dysfunction and VNS aggravate kidney damage.

Summary: conducting therapy, taking into account existing renal dysfunction contributed to the restructuring of the circulatory adaptation, VNS and RAAS close to normal pregnancy, compensation of renal dysfunction.

Purpose: studying of the impact of the general air cryotherapy on oxygen transporting function of the patients’ blood with metabolic syndrome.

Materials and Мethods: 70 patients are included, average age is 45,3Ѓ}3,7 years. The analysis of the indicants of gas transporting function of the patients’ blood with metabolic syndrome before and after the general air cryotherapy course was carried on.

Results: patients with metabolic syndrome revealed the presence of quantitative and modulation adaptation type oxygen transporting blood function and the formation of compensatory-adaptive reactions that support the processes of dissociation of oxyhemoglobin. After a full course of general air creotherapy treatments the clinical group patients are noticed to have the restructuring of oxygen metabolism in the form of a reduction in the tissue hypoxia intensity and enhance of the erythrocytes’ aerobic metabolism processes.

Summary: the obtained results allow to recommend this method of physiotherapeutic effect for patients with metabolic syndrome with the aim to increase endurance and resistance levels towards hypoxic factor in low temperatures conditions.

Purpose: developing and clinical tested a new surgical method of treatment and prevention of gastro-esophageal variceal bleeding in patients with liver cirrhosis.

Materials and Мethods: 18 patients with liver cirrhosis were operated scheduled and urgent indications by original surgical method. Results of surgical treatment were evaluated on the basis of common clinical, laboratory and instrumental studies using radiographic and endoscopic methods.

Results: in the early postoperative recurrence of bleeding none registered. One patient died because of progressive insufficiency of liver.

Summary: the immediate results of the clinical application of the method proved its effectiveness in the treatment and prevention of bleeding from varices of the esophagus and cardia of stomach.

Purpose: comparative estimation of the efficacy of Mantoux test with 2 TE PPD-L, DiaskintestR, and QuantiFERONRTBGoldfor identification of active and latent tuberculosis infection at contact persons.

Materials and Мethods: the study included 220 people from tuberculosis infection foci. All contact persons underwent the Mantoux test with 2 TE PPD-L and the DiaskintestR. The in vitro QuantiFERONRTBGold test was done before the intracutaneous probes. The statistical manipulation of the obtained data was performed using the Statistica 6.0 package under Windows XP.

Results: the Mantoux test with 2 TE PPD-L was reliably not distinguished for persons with active tuberculosis, residual posttuberculosis changes, and latent tuberculosis infections. DiaskintestR and QuantiFERONRTBGold possessed statistically significant differences depending on the investigated group.

Summary: the Mantoux test with 2 TE PPD-L has low sensitivity and specificity, and not effective enough to detect active and latent tuberculosis infection. The usage of DiaskintestR and QuantiFERONRTBGold allows to detect and identify tuberculosis infection both active and latent.

The paper presents results of research on the analysis of the structure and performance of hospital beds hospitalRostovStateMedicalUniversity. Identified unexpressed systematic approach to the reorganization of hospital beds. Calculated the economic effect of reducing the average duration of hospitalization. The calculation was based on the use of actual, planned and standard indicators of hospital performance.

The prognosis of acute myocardial infarction depends upon a complex of factors: clinical manifestations of the disease, age and gender characteristics of a patient, the correctness and efficiency of diagnosis and treatment of the disease.