Toll-like receptors (TLR) can interact with intestinal microflora under physiological steady-state conditions. This interaction is required for intestinal homeostasis. Activation of TLRs by ligands of commensal microflora is required for the protection against gut injury and associated mortality. The normoflora ligands induce the expression of proinflammation and anti-inflammation cytokines. The more active normoflora ligand is lipopolysaccharide (LPS).

The association of arterial hypertension and metabolic abnormalities increases the risk of cardiovascular events. It damages more organs. The correlation between the speed of myocardial hypertrophy and degreeses of metabolic abnormalities has been demonstrated in prospective studies. Interventricular septal thickness depends more significantly on metabolic abnormalities than on the left ventricular chamber size. Besides atrial enlargement has also been associated with overweight and high fasting glucose. Renal events depend on metabolic abnormalities Microalbuminuria has been associated with hyperinsulinemia. The linear link between the prevalence of GFR and the number of metabolic syndrome components has been established. Furthermore, the evidence that artery stiffening is new independent risk factor has been found. This marker connected with obesity. Besides metabolic abnormalities produce a lot of different affective decoders, which can decrease patients quality life and motivations to their treatment.

Logistic conception the process of forming the inter-departmental unificated system of medical force state structures deliveries is presented, where determinated economic-organizational mechanism integrate medical deliveries force structures on the basis tendention the proximity logistic theory and theory of medical deliveries force structures. Proved necessity of the applying logistic in the practical activity of the territorial organs system of medical force structures deliveries, determinated tasks, role and significance of logistic medical deliveries force structures in the new economical conditions.

Purpose: The analysis of problems and alarms of the patient’s relatives served in hospices and the services rendered to it.

Materials and Methods: Questioning of 190 members of the personnel, 216 relatives and the close patients who were in 29 hospices and 5 branches of the palliative help of Bulgaria in 2008.

Results: There is no practice of granting conditions for stay of relatives and maintenance of contacts to relatives after death of the patient in the Bulgarian hospices. Relatives underline absence of free from work of a member of a family and impossibility of reception of long holiday for service of the patient as the basic problems. The basic alarms are connected with a condition of the patient and necessary measures for its service.

Summary: Wide informing of the population on various forms hospice’s help and a special attention of the medical personnel to problems of health of relatives are necessary.

Purpose: To study the dynamics of functional condition of students of different somatotypes with nephroptosis going in for corrective gymnastics.

Materials and Methods: We have examined 62 students (18 males and 44 females) with nephroptosis going in for therapeutic physical training. The weight and height of the body, hand dynamometry, the circumference and excursion of the chest, the vital lung capacity, the index of physical development were made; arterial pressure and pulse were taken; Shtang and Yench tests and abdomen and back strength endurance were carried out. Somato-identification and ultrasonic diagnostics of kidneys were carried out too.

Results: All the patients with nephroptosis were going in for corrective gymnastics. The results were as follows: during the period of 10 months of treatment the average index of hand dynamometry improved, the index of strength endurance increased, the chest excursion became better, abdomen and back strength endurance increased in students of all somatotypes. Ultrasonic diagnostics in patients with nephroptosis became much better.

Summary: The most effective results of the course of corrective gymnastics or therapeutic physical training had stout males and females.

Purpose: To study the central nervous system condition of patients with ischaemic stroke (IS) were estimated with quantitative EEG (QEEG) and with the using of polispectral indexes (PSI) which characterize redistribution spectral power between alfa-, beta- and teta-frequency ranges of EEG.

Materials and Methods: The effectivity of the treatment estimated by using of the scale NIH-NINDS, parameters of which with correlation-regression analysis compared with the PSI and it was obtained respective correlations.

Results: Decreasing of the indexes levels of the ratio teta-rhytm to the alpha-rhytm before/after treatment, teta-rhytm to the beta-rhytm before/after treatment, alpha-rhytm to the beta-rhytm before/after treatment were obtained.

Summary: The given methodological approach has allowed to use spectral indexes EEG as informative parameters and markers of cerebral patients conditions. The analysis of spectral power of rhythms EEG in patients with IS has allowed to establish possibility of use of spectral indexes EEG as informative parameters and markers of cerebral conditions in the course of treatment which is carried out.

Purpose: Research of clinical-immunological characteristics, detection of diagnostic and prognostic significance in pre- and postsurgical periods and immunocorrection potential.

Materials and Methods: 59 pregnant women with gestation period of 38-40 weeks and on the 6-7-th day after labor. Clinical-immunological characteristics, US- factors of postnatal involution of uterus were estimated. The estimation of immune state include research of humoral and cellular components of immune system.

Results: Pregnant women who belong to a risk group after C-section more often have complications in postnatal subinvolution of uterus with dysfunction of immune system on the 6-7-th day after labor. Usage of superlymph in complex therapy is accompanied with a certain clinical effect and normalization of immunogram indices.

Purpose: Determination of effectivity on the basis of estimation the activity KKS and NS in dynamics standard and biocontrol magneticlaser therapy patients with CAP/CPPS IIIA.

Materials and Methods: 1^st group - 42 patients with standard therapy and 2^nd group – patients with biocontrol MLT.

Results: In the blood of patients 2^nd group the activity of α₁-PI (рв<0,001) decrease on 38,8% with comparing relative parameters before treatment. In secret of prostate the activity of α₂ -МG and α₁ -PI became normal, and about 16,1% (р_с <0,001) OAEA decreased. In sperm the activity of α₁ -PI and α₂ -МG became normal under MLT influence, and level of PK, the activity of OAEA increased about 238,0% (р_с <0,001). After treatment in patients of 1^st group production of NO iNOS decreased 30,85% (р_в <0,001) in blood in comparing with relative parameter before treatment. In secret of prostate and sperm of patients 1^st group retain high activity iNOS. In 2^nd group level of NO in all experimental biological fluids became normal. Positive clinical effect from treatment 25 (78,0%) patients from 2^nd group and 24 (56,8%) from 1^st group (р<0,05).

Summary: The employment of biocontrol MLT allow to increase effect of treatment patients with CAP/CPPS IIIA.

Purpose: To develop an option for the anesthetic support of such surgical interventions with the use of human recombinant interleukin-2, which makes it possible to normalize the cytokine balance of the patients with uterine myomas during the surgical stress and in the early post-operative period.

Materials and Methods: The cytokine balance was measured during the surgery and in the early post-operative period in patients with uterine myomas operated on with total intravenous anesthesia and artificial ventilation of the lungs.

Results: Based on a solid-phase immunoenzymatic test, it was found that at all stages of examination of that group of patients there was an imbalance between the pro-inflammatory and the anti-inflammatory links of the cytokine regulation of the course of the adaptation processes.

Purpose: To study the effects of 48 weeks eprosartan therapy on left ventricle (LV) geometry and function condition.

Materials and methods: investigate 34 patients with arterial hypertension 1-2 stage with LV diastolic dysfunction. All patients randomized in 2 groups. Patients in either group received eprosartan in dose 600 mg p/day monotherapy, in other group – 20 mg 2 p/day nifedipine.

Results: At the end of therapy in group with eprosartan occurred reliable normalization geometry end effective tendencies of normalization of diastolic function, at the same time change in other group were non reliable.

Summury: Thus eprosartan is high effective remedy for prevention of HF in patient with arterial hypertension.

Purpose: To investigate quality of prehospital intensive care of traumatic shock in children with severe road-traffic injuries.

Materials and Methods: It was analyzed 61 medical reports of children with severe road-traffic injuries, who were primary hospitalized in the intensive care departments of Rostov region.

Results: Majority of all were transported to the hospitals during 1 hour after disasters (73,8% - 45) by emergency teams (42,6%). Duration of prehospital period was 30 minutes in 41% (25), from 30 minutes till 1 hour – in 32,8% (20), from 60 till 120 minutes – in 18% (11), and more than 120 minutes – in 8,2% (5). Craniocerebral injuries had 96,7% patients, skeletal – 41%, thoracal and abdominal – 36,1% and 21,3%. Infusion prepared in 11,4%, analgesia – in 22,9%, respiratory therapy – in 17,1% and immobilization – in 11,4%.

Purpose: Characteristics of reaction of immune system of patients with severe recurrent herpetic stomatitis were studied, polyoxydonium immunocorrection scheme was developed.

Materials and Methods: Two patient groups were segregated: group I consisting of 9 people, having received 3 mg of polyoxydonium intramuscularly and 3 mg locally under the mucous layer in combined treatment within 3 days; comparison group II, having received only basic treatment.

Results: Systemic and local immunity changes of patients of both groups were registered before beginning the treatment. Polyoxydonium immunocorrection effectiveness is confirmed by pronounced clinical effect, based on the normalization of Systemic and local immunity indicators and decrease of inflammation process intensity.

Purpose: Analysis of rentgenogrammetric parameters of chest department of a columna vertebralis in norm and at an osteochondrosis depending on somatotype.

Material and Methods: To define with rentgenogrammetric methods development proportionality of bone wramework thoracic cage principal elements and to compare them with somatotypes.

Results: The carried out researches with all objectivity allow to recommend allocation of a concrete contingent among pupils of schools and higher educational institutions on somatic types and the presented levels of a variation of anthropo-metric signs as groups of risk of degenerate-dystrophic of columna vertebralis disease (DDCVD).

Summary: The given methodological approach allows to carry out authentic forecasting of presence of degenerate-dystrophic disease of a backbone in teenage, youthful and in the beginning of the first mature period of a life, even in the absence of clinical displays of pathological process. Finally it is obviously possible to spend timely correction of initial stages of development of an osteochondrosis by adequate methods of preventive maintenance and treatment.

Purpose: The retrieval of informative laboratorial criteria of acute myocardial infarction (AMI) and its aftereffects diagnostics for the reason of water homeostasis assessment and oxygen transportation blood function at patients with acute myocardial infarction (AMI) and postinfarction cardiosclerosis.

Matherials and Methods: For the investigation were selected whole blood, plasma and erythrocytes of 200 patients. During the investigation were tested water fractions, content of 2,3-diphosphoglycerat, ectoglobular hemoglobin, the activity of glucose 6-phosphate dehydrogenase.

Results: It was established different types of changes in water homeostasis at patients with acute myocardial infarction and postinfarction cardiosclerosis. It was revealed that in acute period of coronary catastrophe the level of bond water has risen both in whole blood and plasma that is compensator adaptive mechanism to prevent cellular dehydration. The prominent elevation of free fraction of water was found at patients with postinfarction cardiosclerosis that possibly is a leading reason of blood cells and cardiomyocytes hyperhydration.

Purpose: The improvement of medical-social aid to MS patients.

Material and Methods: A prospective epidemiological study (descriptive and ecological), analysis of the peculiarities of MS manifestation and types of clinical courses in the population (983 MS patients) of Rostov region.

Results: An increase of MS prevalence, a considerable index variability in different areas of Rostov region and also an increase of MS mortality in Rostov-on-Don (from 0,452 in 1996 to 0,7 in 2006). In general, the clinical picture does not differ from the one in the population of the European part of Russia.

Summary: There has been a link between MS incidence and ecological situation (dense population as the index of anthropogenic pressure on the environment, habitation in ecologically unfavourable industrial areas).

The article describes the case of successful outcome of the patient after the haemorrhage, that move than 50% of volume of circulating blood, conditions of the patient was complicated by the development of the 3-rd stage of syndrome intravascular curtailing of blood. High doses of antifibrinolytics were used for the treatment.

Scientific researches of employees of faculty for 140 years are various and numerous, they are devoted to questions ethnic and integrative anthropology, studying of variants and anomalies in various systems of bodies of the person, to studying of cardiovascular and nervous systems in age aspect and at a pathology, to questions of anatomic and anthropological technics, comparative and veterinary anatomy. For the 140-years period of work of the Rostov faculty of normal anatomy by its employees it has been published more than 2000 scientific works, 23 monographies, they took part in a writing of 16 textbooks, atlases, dictionaries and 83 manuals and methodical recommendations for students. Under direction of its managers for this period employees had been executed 27 doctor’s and 76 master’s theses. Employees of faculty actively participated in work of forums anatomists and clinical physicians. Authoritative enough Rostov school of anatomists which representatives supervised over anatomic faculties in 14 cities of Russia and abroad was generated. On faculty numerous pupils who expanded have been brought up and multiplied achievements of the Rostov anatomic school.