In this review of literature are discussed prenatal ultrasonic diagnosis of pathological states curve umbilical cord, their impact on obstetric tactics, perinatal outcomes.

The article discusses the genesis of psychogenic and prevention iatrogenic in the practice of obstetrician-gynecologist using in their daily work echography (ultrasonography).

This article presents a short review of historical background for the creation of the general theory of systems. There are also given basic statements of this theory and as well her scientific significance in the field of scientific facts’ synthesis is shown. The greatest emphasis is placed on biotic systems. There are presented the questions of structure, function and evolution in medical and biological aspects.

Nowadays an objective necessity has developed to introduce planning pregnancy as one of the relative indices to the mioectomy operation which is planned by the patient with hysteromyoma, irrespective of the fertility level of patient with hysteromyoma equal to 10 weeks and more and with a technical possibility to remove myometrial nodes without any essential risk of widening of surgical intervention volume. Laparoscopic access during miomectomy is appropriate only during the presence of three and more subserous nodes. Moreover, the diameter of the dominant node must not be more than 8-10 cm.

Purpose: To develop the method of prenatal invasive diagnosis and compare it abilities with traditional genetic cytological examination.

Materials and Methods: There was conducted prenatal fetal invasive diagnosis of 366 pregnant women. Depending on the pregnancy age and genetic indications the chorionic villus sampling, cordocentesis and amniocentesis were carried.

Results: The obtained samples was treated with QF-PCR and it results was verified by standard karyotyping. In all cases, the differences of the two methods was not observed.

Summary: It was shown the technique of quantitative fluorescent polymerase chain reaction (QF-PCR) has advantages over the standard cytologic examination and reduces analysis duration and increases the number of patients.

Purpose: To examine the profile of cytokines and gormones in maternal serum of first-trimester pregnancies complicated by threatened abortion (TACP).

Materials and Methods: Serum levels of interleukin-2 and -6, tumor necrosis factor alpha (TNF-alpha), corticotropin-releasing hormone (CRH), activin A, VEGF, sFlt, PGF were measured, by ELISA, in 24 women with TACP and adverse outcome (group IV) and compared with the corresponding levels of 35 women with TACP and successful outcome (group II) and 21 miscarriage (group III) and 26 women with first-trimester uncohreatened abortionmplicated pregnancy (group I) who served as controls. AtteStat 7.3, MedCalc, Microsoft Excel 2003, Statistica 6.0, Spirmen or Wilcoxon test were used for analysis.

Results: IL-2 and -6 were detected lower and TNF-alpha and activin A were detected higher with no significant difference in group I, compared to all other groups. Only TNF-alpha in group II were detected lower with significantly levels, compared to I group. sFlt in all groups was detected lower, compared to I group. VEGF and CRH were detected lower in II and III groups and higher in IV group, compared to I group. PGF was detected higher in III group and lower in II and IV groups, compared to I group.

Summary: In first-trimester TACP with adverse outcome, allteration of maternal angiogenic factors, activin A, IL and CRH levels, compared to first-trimester uncomplicated pregnancy and TACP wihreatened abortionth successful outcome, is relevant to the occurrence of miscarriages.

Purpose: To reveal peculiarities of angiogenesis from the pint of autoparacrine cellular regulation and to amplify the mechanisms of formation of external genital endometriosis.

Materials and Methods: 352 patients were divided to 3 clinical groups: I - 148 patients with I-II stages of EHE, II group -184 patients with III-IV stage, 24 ones among them were with relapse. The III control group was presented by 20 patients without endometriosis. We used clinical methods, clinicolaboratory methods, genetic, morphological, biochemical.

Results: On the systemic level the disorders of auto–para– and intracrine cellular regulation of angiogenesis with high production of EGF, bFGF, IGF-1, VEGF, solutable receptor of EGF and sFlt and low production of leptin. On the local level we found severe decrease of apoptosis, which was devoted to IL-8, NO, FSH and the simultaneous reinforcement by IL-8 of angiogenesis activity in endometrioid heterotopies and also the capillary vasodilatation with participation of NO. The increase of VEGF production on systemic level and high content of solutable receptor of VEGF, NO and NO- syntaze on the local level (the peritoneal fluid) are typical for relapsing of EGE.

Summary: The switсhing of disorder of regulatory control of the cellular metabolism from one growth factors to another is happened in different stages of external genital endometriosis formation.

Purpose: To prove pathogenically the addition of immunocorrection in a complex treatment of an external endometriosis conjugated with the sterility, and to access its effectiveness.

Materials and Methods: There are two groups of patients: the I group (73 patients) – received Roncoleikin in a complex treatment, the II group (72 patients) – were given only traditional therapy.

Results: Inclusion of the Roncoleikin (at the system and local levels) in the complex therapy of the patients with EGE of the first and second stages, who are suffering from the sterility, is proved pathogenically and allows to increase the effectiveness of the treatment: it allows to achieve the desired pregnancy and the regression of other symptomatology 1.5 times more often compare to traditional therapy.

Summary: At the current stage the inclusion of an adequate immunomodulating therapy in the complex differential treatment of the patients with EGE suffering from sterility, with the account of the process’ activity, is a perspective way in the study of this problem.

Purpose: To estimate the influence of human immunodeficiency virus (HIV) infection on pregnancy, childbirth and neonatal status.

Materials and Methods: In total, 54 pregnant women infected with HIV-infection (study group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of newborn babies and their incidence.

Results: Pregnancy in HIV infection more severe with various complications: anemia, placental insufficiency and preeclampsia. The frequency postnatal of new complications in parturients infected with HIV, is significantly higher, significantly more children are born with perinatal diseases mainly due to slowing growth and fetal malnutrition and disorders related to shortening the duration of pregnancy and low birth weight.

Summary: HIV infection is one of the factors influencing the course of pregnancy and the development of perinatal pathology in infants. Combination of HIV with other specific infectious diseases and / or chronic pyelonephritis does not increase the frequency of perinatal pathology in infants.

Purpose: Assessment of the impact of chronic pyelonephritis (CP) on pregnancy, childbirth and the state of a newborn.

Materials and Methods: 64 pregnant women with chronic pyelonephritis (study group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of the newborn babies and their incidence. To detect virus-bacterial pathogens persisting in the urine of infants born to mothers with HP, examined 42 children. All isolates were determined rates of adhesion and persistence factors (antilizotsim (ALA) and antiinterferon (AIA) activity). In the urine of surveyed defined mycoplasma, chlamydia, herpes simplex virus type I and II, Epstein-Barr virus, cytomegalovirus, and papilloma viruses using standard polymerase chain reaction (PCR).

Results: Pregnancy complicated by HP more severe with various complications: anemia and placental insufficiency. In patients with CP were significantly more marked prematurity (6,25% versus 1,6% in the comparison group). In assessing the viral-bacterial infection of the urine of infants born to mothers suffering from CP, 50% of the bacterial population was observed in 50% were identified opportunistic bacteria in an amount not to exceed thresholds.

Summary: Chronic pyelonephritis is one of the factors influencing the course of pregnancy. Perinatal morbidity in children born to women who suffer from CP, no more than general population values. Significant correlation between the microflora of mother and child is absent.

Purpose: To estimate the influence of infection with syphilis during pregnancy, birth and state of the newborn.

Materials and Methods: surveyed 51 pregnant women with syphilis (study group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of newborn babies and their incidence.

Results: The condition of pregnant women with siphyllis, significantly different from the state of apparently healthy women. Pregnancy in syphilis more severe with a high incidence of personal time complications. The combination of syphilis with other specific infectious disease worsens during pregnancy. Influence of syphilis during the birth itself and the frequency of obstetric complications among women in childbirth was not revealed. Women with syphilis were significantly more premature babies are born. Differences in the incidence of other perinatal diseases were found. The combination of syphilis with other specific infectious diseases greatly in creases the incidence of perinatal pathology in infants.

Summary: Syphilis is one of the factors influencing the course of pregnancy and development of perinatal pathology in infants.

Purpose: Assessment of the impact of tuberculosis on pregnancy, childbirth and neonatal status.

Materials and Methods: A total of 50 pregnant women suffering from pulmonary tuberculosis (study group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of newborn babies and their incidence.

Results and Summary: Obtained in the course of the study data suggest, at first sight paradoxical conclusion: during pregnancy in women with pulmonary TB, and especially the delivery and newborn state does not fundamentally differ from those in the control group.

Purpose: Estimate the influence of infection with hepatitis C virus (HCV) on pregnancy, childbirth and neonatal status.

Materials and Methods: Examined 49 pregnant women with HCV (core group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of newborn babies and their incidence.

Results: Pregnancy with HCV occurs with a high incidence of placental insufficiency (almost 2 times more frequently than in the control group, p < 0,05). Effect of HCV on the course of childbirth is not revealed: progress of labor in most cases the same way as in the comparison group. However, in almost equal amounts of blood loss in groups the frequency of postpartum anemia in parturients infected with HCV, we observed significantly more frequently (p < 0,05). The structure of perinatal pathology in infants of women infected with HCV, represented mainly by slowing growth and fetal malnutrition and disorders related to shortening the duration of pregnancy and low birth weight.

Summary: HCV is a factor influencing the course of pregnancy, but does not affect the development of perinatal pathology in infants.

Purpose: Estimation of correction efficiency of a microbiocenosis of a vagina at pregnant women in risk group with application Vaginorma-C.

Materials and Methods: 171 woman with interrupted pregnancy in II trimester were studied. An expanded patomorphological research of fetoplacental material was carried.

Results: The given pathology is caused in 82% of cases by an placenta infection with conditional-pathogenic microflora. In 70% of cases bacterial vaginosis was founded. The risk of premature birth and amniorrhea increase in 2,6-3 times.

Summary: The new approach to the preventive measures was suggested during the bacterialveginosis – oxidation of vaginal medium with the usage of the drug Vaginorm-С.

Purpose: Clinical particularities and conditions of the vegetative nervous system from the patients with forming polycystic ovary syndrome were studied.

Materials and Methods: 364 patients aged 16-18 years old with forming polycystic ovary syndrome were examined. The control group included 364 practically healthy girls of the similar age with normal physical and sexual development. Methods of investigation included patient complaints and anamnestic data acquisition, clinical and gynecology survey, biological modeling of forming polycystic ovary syndrome.

Results: It was determined that the patients with forming polycystic ovary syndrome had different breaches of vegetative and hormonal status and the exchange of catecholamine.

Summary: Patients with forming polycystic ovary syndrome are in the high-risk group of the development of primary infertility, cardiovascular and oncologic pathology. They need carrying out timely dispensary actions directed on early diagnostics and timely treatment, including complex correction of the vegeto-hormonal status.