Chronic eczema. The search for treatment of severe forms
https://doi.org/10.21886/2219-8075-2019-10-1-72-78
Abstract
Objective: to study the clinical efficacy of re-PUVA therapy in patients with torpid forms of chronic true hand eczema. Materials and methods: the study involved 78 patients (47 women, 31 men) with severe and moderate forms of chronic true hand eczema. Clinical indices were used before and after treatment: HECSI, DLQI. The patients were randomly divided into 3 groups: 1 group (25 people) received standard therapy (antihistamines, external glucocorticosteroid drugs, emollients); 2 group (27 people) received the indicated standard therapy against the background of PUVA; Group 3 (26 people) -standard therapy on the background of re-PUVA (combination of PUVA with retinoids (isotretinoin)). The duration of therapy was about 3 months. Results: in group I, before treatment, the average value of the HECSI index was 76.0 ± 37.9, and after the treatment, 63.6 ± 30.2; in group II, before treatment, the average value of the HECSI index was 78.3 ± 34.2, and after treatment it decreased to 51.5 ± 24.0, in group III, respectively, before treatment, the average HECSI was 77.2 ± 35.3, and after course of therapy 28.7 ± 14.0. The duration of remission in the first group after a course of standard therapy was 2.52 ± 1.1 weeks, in the second group 15.7 ± 7.5 weeks, in the third group 61.7 ± 32.4 weeks. Conclusions: The re-PUVA method is most effective in the treatment of chronic eczema of the hands in comparison with the PUVA and standard therapy.
About the Authors
Vyacheslav V. Starostenko
Rostov State Medical University
Russian Federation
assistant, department of the skin and venereal diseases
Russian Federation
assistant, department of the skin and venereal diseases
Olga An. Sidorenko
Rostov State Medical University
MD, Prof., department of the skin and venereal diseases
MD, Prof., department of the skin and venereal diseases
Lyudmila P. Sizyakina
Rostov State Medical University
MD, Prof., department of the allergology and immunology
MD, Prof., department of the allergology and immunology
Elizaveta Ev. Sidorenko
Rostov State Medical University
resident, department of the skin and venereal diseases
resident, department of the skin and venereal diseases
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Review
For citations:
Starostenko V.V., Sidorenko O.A., Sizyakina L.P., Sidorenko E.E. Chronic eczema. The search for treatment of severe forms. Medical Herald of the South of Russia. 2019;10(1):72-78. (In Russ.) https://doi.org/10.21886/2219-8075-2019-10-1-72-78
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