The role of glycosaminoglycanes in the development of intimal hyperplasia in the shunting of coronary arteries
https://doi.org/10.21886/2219-8075-2018-9-3-94-98
Abstract
The article is devoted to the study of the role of glycosaminoglycans (hyaluronic acid, heparan sulfate derivatives, dermatan sulfate) in the genesis of intimal arterial hyperplasia. It is shown that these substances play important role in the structural reorganization of vessels, including the development of intimal hyperplasia of the arteries. Scientific works on the role of GAG in the genesis of intimal hyperplasia are based on experimental data. The authors draw attention to GAG involvement in cell-intercell nteractions of artery walls, including proliferation, migration, signal transduction of smooth muscle cells, endotheliocytes, platelets. Undoubtedly, attempts to create a 3D shunt with hyaluronate, atorvastatin can be used in the clinic for full and longterm use, which can prevent the development of restenosis of the arteries.
About the Authors
S. S. Todorov
Rostov state medical university, Rostov-on-Don
Russian Federation
Russian Federation
Sergey S. Todorov, PhD, head of morphological Department
R. V. Sidorov
Rostov state medical university, Rostov-on-Don
Russian Federation
Russian Federation
Roman V. Sidorov, PhD, associate Professor of the surgical diseases chair N 2
E. P. Talalaev
Rostov state medical university, Rostov-on-Don
Russian Federation
Russian Federation
Egor P. Talalaev, post-graduate student of the surgical diseases chair N2
I. F. Shlyk
Rostov state medical university, Rostov-on-Don
Russian Federation
Russian Federation
Irina F. Shlyk, PhD, cardiologist, Rostov regional clinical hospital
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Review
For citations:
Todorov S.S., Sidorov R.V., Talalaev E.P., Shlyk I.F. The role of glycosaminoglycanes in the development of intimal hyperplasia in the shunting of coronary arteries. Medical Herald of the South of Russia. 2018;9(3):94-98. (In Russ.) https://doi.org/10.21886/2219-8075-2018-9-3-94-98
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