UNIQUE FEATURES OF METABOLIC DISORDERS OF CONNECTIVE TISSUE IN POSTOPERATIVE ABDOMINAL HERNIA AND ITS POSSIBLE RESOLUTION
https://doi.org/10.21886/2219-8075-2017-8-3-33-37
Abstract
Objective: study and analyse features of metabolic disorders of connective tissue in postoperative abdominal hernia and its possible resolution.
Materials and methods: 68 patients with postoperative ventral hernias of different age groups were studied and screening of undifferentiated connective-tissue syndromes (UCTS) was carried out, to study its metabolic markers.
Results: it has been proved that with aging, there is an increase binded hydroxyproline, indicating increased fibrillogenesis. In patients in age group of 51-60 years, there was an increase in the free hydroxyproline, confirming the predominance of collagen breakdown over its synthesis. With increase in severity of UCTS, there was an increase in the level of free hydroxyproline, indicating a more pronounced decay of collagen. At the same time, faster recovery was noticed in collagen metabolism in the postoperative period in groups of patients with mild and moderate UCTS severity.
Conclusions: collagen breakdown is more pronounced in patients with severe UCTS and its recovery in the postoperative period is directly related to the severity of UCTS that requires pharmacological resolution.
About the Authors
S. G. Grivenko
V.I. Vernandskiy Crimean Federal University
Russian Federation
Russian Federation
Sergey G. Grivenko — PhD, associate professor of the Surgery Department No. 2, S.I. Georgievsky Medical Academy
Simferopol
N. N. Derkach
V.I. Vernandskiy Crimean Federal University
Russian Federation
Russian Federation
Nikolay N. Derkach — Post-graduate student of the Surgery Department No. 2, S.I. Georgievsky Medical Academy
Simferopol
E. R. Kondratyuk
V.I. Vernandskiy Crimean Federal University
Russian Federation
Russian Federation
Evelina R. Kondratyuk — PhD, Assistant of the Department of Surgery No. 2, S.I. Georgievsky Medical Academy
Simferopol
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Review
For citations:
Grivenko S.G., Derkach N.N., Kondratyuk E.R. UNIQUE FEATURES OF METABOLIC DISORDERS OF CONNECTIVE TISSUE IN POSTOPERATIVE ABDOMINAL HERNIA AND ITS POSSIBLE RESOLUTION. Medical Herald of the South of Russia. 2017;8(3):33-37. (In Russ.) https://doi.org/10.21886/2219-8075-2017-8-3-33-37
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