PATHOPHYSIOLOGICAL ASPECTS OF INFLAMMATORY REACTION IN DIFFERENT TYPES OF ATHEROSCLEROTIC PLAQUES OF CAROTID ARTERIES
https://doi.org/10.21886/2219-8075-2016-1-59-63
Abstract
Purpose: to compare between the ultrasound investigation data and cytokines level, lipids in blood, histologic pattern in the atherosclerotic plaques of different types in injury of inner carotid arthery.
Materials and methods: this work is grounded on study results and treatment of 130 patients, which were divided into two groups: with stable plaques (73 patients) and unstable plaques (57 patients).
Results: by comparing the ultrasound imaging results and clinical pattern it was established that the most significant are atherosclerotic plaques near 3 mm and more and plaques with ulceration as well. Atherosclerotic plaque destruction is accompanied by the higher levels of anti-inflammatory cytokines, such as TNF, IL-6, CRP and anti-inflammatory cytokine IL-10. All the patients experienced an index increase of total cholesterol, HDLP, LDLP, VLDLP and triglycerides.
Summary: atherosclerotic plaque destabilization is accompanied by TNF concentration increase 15,9±1,91 pg/ml, IL-6 16,3±1,8 pg/ml, IL-10 4,92±0,82 pg/ml and CRP 8,42±1,21 pg/ml. It was established a strong correlation connection between the confirmed presence of unstable atherosclerotic plaque in patient, ultrasound imaging data as well as histologic investigation.
About the Authors
V. Yu. Mikhailichenko
Institute of Urgent and Recovery Surgery named after V.K. Gusak, NAMS of Ukraine, 47 pr. Leninsky, Donetsk region, Donetsk, Ukraine, 83045
Russian Federation
Russian Federation
M. A. Belocerkovskay
Institute of Urgent and Recovery Surgery named after V.K. Gusak, NAMS of Ukraine, 47 pr. Leninsky, Donetsk region, Donetsk, Ukraine, 83045
Russian Federation
Russian Federation
N. V. Yasnopolskay
Institute of Urgent and Recovery Surgery named after V.K. Gusak, NAMS of Ukraine, 47 pr. Leninsky, Donetsk region, Donetsk, Ukraine, 83045
Russian Federation
Russian Federation
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Review
For citations:
Mikhailichenko V.Yu., Belocerkovskay M.A., Yasnopolskay N.V. PATHOPHYSIOLOGICAL ASPECTS OF INFLAMMATORY REACTION IN DIFFERENT TYPES OF ATHEROSCLEROTIC PLAQUES OF CAROTID ARTERIES. Medical Herald of the South of Russia. 2016;(1):59-63. (In Russ.) https://doi.org/10.21886/2219-8075-2016-1-59-63
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