Dynamics of the content of shaped blood elements and phagocytic activity of neutrophils in patients with acute coronary syndrome in the postcovoid state and without it, depending on the number of CD8⁺T-lymphocytes

Objective: To evaluate hematological parameters and neutrophil phagocytic activity in patients with acute coronary syndrome (ACS) with and without post-COVID syndrome (PCS), according to CD8⁺ T-lymphocyte counts. Materials and methods: Sixty-five men with ACS were examined. Complete blood counts, neutrophil phagocytic activity, and CD8⁺ T-lymphocyte counts were assessed at baseline and on day 28. Results: The greatest leukocytosis was observed in patients whose CD8⁺ T-lymphocyte counts were within the reference range; leukocyte counts in this group decreased significantly by day 28 (p<0.05). Phagocytic intensity of neutrophils increased significantly in patients with reduced CD8⁺ counts, regardless of PCS status. The phagocytic number of neutrophils also increased significantly over time in the low-CD8 group (p<0.05). NBT-induced activity and index decreased significantly in PCS patients with CD8⁺ counts within the reference range. Conclusions: After coronary stent implantation, patients with ACS and either low or normal CD8⁺ T-lymphocyte counts showed by day 28 a reduction in leukocytes, granulocytes and band neutrophils and an increase in lymphocytes, consistent with a beneficial effect of stenting. The phagocytic number and phagocytic intensity of neutrophils increased significantly in patients with reduced CD8⁺ counts (both with and without PCS), whereas NBT-induced activity and index decreased (p<0.05) in PCS patients with CD8⁺ counts within the reference range.

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