ENDOTHELIAL DYSFUNCTION IN DEVELOPMENT OF VARICOSE VEINS OF LOWER EXTREMITIES AND POSSIBILITIES OF IT’S CORRECTION
https://doi.org/10.21886/2219-8075-2014-4-113-119
Abstract
Purpose: To study pathologic processes of the venous wall, prior to the appearance of it’s irreversible changes for prevention of venous diseases and improve results of treatment of patients with varicose veins of lower extremities.
Materials and Methods: Conditions of endothelium was studied in 92 patients with varicose veins of lower extremities by determining the level of markers of endothelial dysfunction: P-selectin, E-selectin, tissue plasminogen activator, endothelin-1, adhesion molecules vascular endothelial type 1 (sVCAM-1), circulating endothelial cells.
Results and Summary: the severity of examined markers can be an indication of the activity of varicose processes of transformation veins. Patients with varicose veins of lower extremities in postoperative and long-term follow-up are advisable to determine commissions, VCAM-1, P - and E-selectins, t-PA and endothelin-1 in order to perform diagnostics of the functional state of the endothelium, inflammatory processes in varicose veins. Indicators of endothelial dysfunction prospectively also be used to monitor the effectiveness of conservative treatment of chronic venous insufficiency.
Materials and Methods: Conditions of endothelium was studied in 92 patients with varicose veins of lower extremities by determining the level of markers of endothelial dysfunction: P-selectin, E-selectin, tissue plasminogen activator, endothelin-1, adhesion molecules vascular endothelial type 1 (sVCAM-1), circulating endothelial cells.
Results and Summary: the severity of examined markers can be an indication of the activity of varicose processes of transformation veins. Patients with varicose veins of lower extremities in postoperative and long-term follow-up are advisable to determine commissions, VCAM-1, P - and E-selectins, t-PA and endothelin-1 in order to perform diagnostics of the functional state of the endothelium, inflammatory processes in varicose veins. Indicators of endothelial dysfunction prospectively also be used to monitor the effectiveness of conservative treatment of chronic venous insufficiency.
About the Authors
Y. L. Shevchenko
National Medical Surgical Center n.a. N.I. Pirogov
Russian Federation
Russian Federation
Y. M. Stoyko
National Medical Surgical Center n.a. N.I. Pirogov
Russian Federation
Russian Federation
G. G. Gudymovich
National Medical Surgical Center n.a. N.I. Pirogov
Russian Federation
Russian Federation
A. M. Nikitina
National Medical Surgical Center n.a. N.I. Pirogov
Russian Federation
Russian Federation
References
1. Покровский А.В., Сапелкин С.В. Хроническая венозная недостаточность нижних конечностей — современные проблемы диагностики, классификации, лечения // Ангиология и сосудистая хирургия. - 2003. – Т.9, №1. - С. 53-60.
2. Основы клинической флебологии / Под ред. Ю.Л. Шевченко, Ю.М. Стойко.2-е изд., испр. и доп.-М.: ЗАО «Шико», 2013.-336 с.
3. Bergan J.J. The vein book. London, 2007. – 617 p.
4. Шевченко Ю.Л., Стойко Ю.М., Гудымович В.Г. и др. Дисфункция эндотелия у больных варикозной болезнью нижних конечностей и возможности ее коррекции //Ангиология и сосудистая хирургия. – 2010. – Т.16, №4. – С. 99-104.
5. Швальб П.Г., Ухов Ю.И. Патология венозного возврата из нижних конечностей. – Рязань, 2009. – 152с.
6. Петрищев Н.Н. Дисфункция эндотелия. Причины, механизмы, фармакологическая коррекция / Н.Н. Петрищев. – СПб.: СПбГМУ, 2003. – 184с.
7. Ciuffetti G., Lombardini R., Pasqualini L., et al. Circulating leucocyte adhesion molecules in chronic venous insufficiency // Vasa. – 1999. - Vol. 28, № 3. - P. 156-159.
8. Michiels C., Bouaziz N., Remacle J. Role of the endothelium and blood stasis in the appearance of varicose veins // Int. Angiol. – 2002. - Vol.21, №1. – P. 1-8.
Review
For citations:
Shevchenko Y.L., Stoyko Y.M., Gudymovich G.G., Nikitina A.M. ENDOTHELIAL DYSFUNCTION IN DEVELOPMENT OF VARICOSE VEINS OF LOWER EXTREMITIES AND POSSIBILITIES OF IT’S CORRECTION. Medical Herald of the South of Russia. 2014;(4):113-119. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-113-119
Views:
564
Email this article 