GENETIC POLYMORPHISMS AS THE RISK FACTOR IN THE DEVELOPMENT OF OSTEOARTHRITIS
https://doi.org/10.21886/2219-8075-2014-2-13-20
Abstract
It’s well-known that osteoarthritis (OA) is a widespread form of degenerative joint disorder that has the significant genetic component. The studies concerning the role of various candidate genes in the OA development are analyzed; much attention is given to the exploration of matrix metalloproteinases, their inhibitors and interleukin genes polymorphisms. The paper describes the results of up-to-date genome-wide association scanning and meta-analyses of polymorphisms associated with osteoarthritis in detail. The paper also considers the problem of the linkage between epigenetic alterations and the susceptibility to OA.
About the Author
S. B. Panina
Southern Federal University
Russian Federation
Biochemistry and microbiology department
Russian Federation
Biochemistry and microbiology department
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Review
For citations:
Panina S.B. GENETIC POLYMORPHISMS AS THE RISK FACTOR IN THE DEVELOPMENT OF OSTEOARTHRITIS. Medical Herald of the South of Russia. 2014;(2):13-20. (In Russ.) https://doi.org/10.21886/2219-8075-2014-2-13-20
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