mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2014-2-13-20mvjr-165Research ArticleОБЗОРЫREVIEWПОЛИМОРФИЗМЫ ГЕНОВ КАК ФАКТОР РИСКА РАЗВИТИЯ ОСТЕОАРТРОЗАGENETIC POLYMORPHISMS AS THE RISK FACTOR IN THE DEVELOPMENT OF OSTEOARTHRITISПанинаС. Б.PaninaS. B.

кафедра биохимии и микробиологии

Biochemistry and microbiology department

tailana@donnetwork.ruЮжный федеральный университетРоссияSouthern Federal UniversityRussian Federation201430062014021320Copyright © Панина С.Б., 20142014Панина С.Б.Panina S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/165

Известно, что остеоартроз как распространенная форма дегенеративной патологии сустава имеет важный генетический компонент. Проведен анализ литературных источников, касающихся роли различных кандидатных генов в развитии остеоартроза, при этом много внимания уделено полиморфизму генов матриксных металлопротеиназ, их ингибиторов и генов интерлейкинов. Статья детально описывает результаты современных полногеномных анализов и мета-анализов ассоциаций полиморфизмов с данным заболеванием. Также обсуждается вопрос связи эпигенетических изменений и риска развития остеоартроза.

It’s well-known that osteoarthritis (OA) is a widespread form of degenerative joint disorder that has the significant genetic component. The studies concerning the role of various candidate genes in the OA development are analyzed; much attention is given to the exploration of matrix metalloproteinases, their inhibitors and interleukin genes polymorphisms. The paper describes the results of up-to-date genome-wide association scanning and meta-analyses of polymorphisms associated with osteoarthritis in detail. The paper also considers the problem of the linkage between epigenetic alterations and the susceptibility to OA.

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The authors declare that there are no conflicts of interest present.