THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION
https://doi.org/10.21886/2219-8075-2013-4-72-77
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Purpose: To study the role of pro-inflammatory and anti-inflammatory cytokines, Toll-like receptors in the pathogenesis of respiratory disorders in full-term newborns.
Materials and methods. The programme of examination included the determination of production of IL-1β, IL-6, IL-8, TNF-α, TGF-β1 and RANTES in bronchoalveolar lavage and blood serum as well as expression of Toll-like receptors on monocytes of peripheral blood in newborn babies with respiratory disorders. Cytokines in the bronchoalveolar lavage, blood serum and expression of Toll-like receptors on the monocytes of peripheral blood were determined in 36 full-term newborns.
Results. The study showed peculiarities of a cytokine profile. In case of respiratory disorders caused by meconium aspiration syndrome (MAS) and respiratory distress syndrome (RDS) high levels of IL-1β, IL-6, IL-8 and TNF–α were revealed in the blood serum and the bronchoalveolar lavage. In the peripheral blood of the newborns with respiratory disorders there was reduced expression of TLR-2 (CD14+CD282+) and TLR-4 (CD14+CD284+).
Summary. The received data indicate an important role of the mechanisms of local protection and inborn immunity in the course and the outcome of respiratory disorders in newborn babies.
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M. V. Dudareva
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Россия
Россия
Department of Obstetrics and Gynecology
43, Mechnikova Str., Rostov-on-Don, 344012##submission.citations##
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Dudareva M.V. THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION. Medical Herald of the South of Russia. 2013;(4):72-77. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-72-77
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