THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION
https://doi.org/10.21886/2219-8075-2013-4-72-77
Abstract
Purpose: To study the role of pro-inflammatory and anti-inflammatory cytokines, Toll-like receptors in the pathogenesis of respiratory disorders in full-term newborns.
Materials and methods. The programme of examination included the determination of production of IL-1β, IL-6, IL-8, TNF-α, TGF-β1 and RANTES in bronchoalveolar lavage and blood serum as well as expression of Toll-like receptors on monocytes of peripheral blood in newborn babies with respiratory disorders. Cytokines in the bronchoalveolar lavage, blood serum and expression of Toll-like receptors on the monocytes of peripheral blood were determined in 36 full-term newborns.
Results. The study showed peculiarities of a cytokine profile. In case of respiratory disorders caused by meconium aspiration syndrome (MAS) and respiratory distress syndrome (RDS) high levels of IL-1β, IL-6, IL-8 and TNF–α were revealed in the blood serum and the bronchoalveolar lavage. In the peripheral blood of the newborns with respiratory disorders there was reduced expression of TLR-2 (CD14+CD282+) and TLR-4 (CD14+CD284+).
Summary. The received data indicate an important role of the mechanisms of local protection and inborn immunity in the course and the outcome of respiratory disorders in newborn babies.
About the Author
M. V. Dudareva
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology
43, Mechnikova Str., Rostov-on-Don, 344012References
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For citations:
Dudareva M.V. THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION. Medical Herald of the South of Russia. 2013;(4):72-77. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-72-77
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