THE ROLE OF CYTOKINES AND AGMATINE IN THE DEVELOPING PLACENTA WITH PHYSIOLOGICAL AND PREGNANCY COMPLICATED

Purpose: To study the content of cytokines and agmatine in the development of the placenta in physiological and complicated gestation.

Materials and Methods: 57 women, of which 34 women with physiological pregnancy and 23 women with placental insufficiency were examined. In the early chorion after the abortion and full-term placenta the content of the transforming growth factor (TGF-α and TGF-β), tumor necrosis factor-α (TNF-α) was studied by means of the immune-enzyme analysis. The level of agmatine was studied by capillary electrophoresis.

Results: In the process of normal gestation the increase of the placental production both of the TGF-α and TGF-β was established. During the pregnancy complicated with placental insufficiency and abortion in the first trimester the content of TGF-β and TNF-α was raised, and content of TGF-α was lowered in comparison with the physiological values. For agmatine differently directed changes were revealed: in the early stages of its level was reduced, and by the end of gestation - increased compared with physiological pregnancy.

Summary: The revealed changes of the production processes of the cytokines and agmatine in the placenta may have the pathogenic meaning in the abortion and placental insufficiency development. 

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