In article resulted data on features of morpho-functional processes in a female organism under the influence of an ethnic factor. It is emphasized that these features are defined by set of genetically caused properties and morpho-functionalsigns of the live systems created according to features of surrounding environment. Results of research of obstetric pathology, growth rates of a fetus, morphometric indeces of women of various ethnic groups are presented. Prospects of the ethnic direction are defined when developing regional standards. 

Violation of the natural defense mechanisms of endothelial dysfunction and an imbalance can occur many neurohumoral factors. The imbalance of angiogenic and antiangiogenic growth factors, endothelial, platelet factor closely related to disorders of hemostasis, promotes the development of generalized endothelial dysfunction and is the basis of placental insufficiency, and is central to fetal growth and neonatal characteristics of the child’s development. The mechanisms regulating these processes in normal and pathological conditions play an important role of thromboxane and prostacyclin, which are derivatives of polyunsaturated fatty acids. Which indicates the feasibility of studying the role of vascular endothelial growth factor and hemostasis disorders in children with fetal growth retardation syndrome. 

This review presents the data of the foreign and domestic authors concerning the basic theories of endometriosis and its diagnosis. The current state of proteomic researches on search and identification of markers of an endometriosis is discussed. 

In a review of literature from the modern point of the mechanisms of observed during physiological and pathological pregnancy. Present and discuss the various hypotheses of gestation. In particular, shows evidence of local immunosuppressive role in the development of pregnancy. At the same time actively involved antigens HLA class, natural killer cells, and pro-and antiinflammatory cytokines. In normal pregnancy, the cytokine balance towards the immunosuppressive Th-2 cytokines that inhibit the cellular immune response and stimulating steroids (progesterone, hCG) and the development of blocking antibodies. The role of apoptosis and T regulatory cells in the pathogenesis of complicated pregnancy. It is assumed that during pregnancy there is a unique interaction between the innate and adaptive immune mothers, the role of chief executives of the regulatory cells perform, asking for the innate immune response. 

Due to the fact that preeclampsia remains one of the difficult issues in obstetrics and is one of the main reasons of maternal and perinatal morbidity and mortality all over the world, the data of late years about the possibility to predict this complication is summarized in the review. The authors consider the risk factors of preeclampsia development and some aspects of its pathogenesis. Possible methods to predict the given pathology in the first trimester of pregnancy are recommended. 

Purpose: To determine the content of corticotropin-releasing hormone, substance P, prostaglandin F2a, neurokinins A and B, interleukins 6 and 8, relaxin and cortisol in the blood serum and amniotic fluid and to evaluate the influence of these markers on the biomechanism of labor.

Materials and methods: 100 parturient women were included in the study. Criteria for including in the group were the gestation term of 38 and more weeks and the absence of endocrine pathology. The blood serum and the amniotic fluid of the patients divided into 3 groups were studied by ELISA technique.

Results: In the course of study it was revealed that the rise in the concentration of corticotropin-releasing hormone, relaxin and cortisol in the blood serum together with low content of prostaglandin F2α increased the probability of labor anomaly development.

Summary: It should be noted that the course of labor and its outcome depend not only on the absolute values of biological substances in the studied media, but also on their interaction before and during labor. 

Purpose: To investigate the role of ciliary and brain-derived neurotrophic factors in the development of diabetic peripheral neuropathy in children and teenagers with type-1 diabetes (T1D).

Materials and methods: The article contains check-up results of 223 children and teenagers with type-1 diabetes. The authors evaluated clinical and functional parameters, which indicate the formation of diabetic peripheral neuropathy, and the content of ciliary and brain-derived neurotrophic factors in the blood serum in the observed patients.

Results: The criteria of early diagnosis and prognosis of severe clinical course of diabetic peripheral neuropathy were developed.

Summary: Statistically significant increase of the levels of ciliary and brain-derived neurotrophic factors rising in case of longterm decompensated course of disease in the blood serum was determined. Markers of early formation and prognostic indicators of severe clinical course of diabetic peripheral neuropathy in children and teenagers were revealed. 

Purpose: To determine the diagnostic value of peroxynitrite and brain-derived neurotrophic factor in the genesis of perinatal lesions of the central nervous system.

Materials and methods: 67 children were comprehensive survey during the first three months of life. All neonates were randomized and put into 4 groups, depending on the presence and severity of perinatal lesions of the central nervous system. The 1 group consisted of 15 infants with delayed manifestationt of perinatal lesions to the central nervous system. Тhe 2 group consisted of 19 children with cerebral ischemia (CI) I degree; in group 3 were 18 infants with CI II-III degree. The control group consisted of 15 healthy newborns. In the dynamics of observation in children was evaluated neurological status. The serum concentration rations of peroxynitrite by spectrophotometry and brain-derived neurotrophic factor using enzyme immunoassay system.

Results: There were significant differences between production of peroxynitrite and brain-derived neurotrophic factor in children with disorders of the central nervous system as compared with control values.

Summary: These changes underlie the formation of perinatal CNS, which allows us to consider them not only as markers of early diagnosis of perinatal brain lesions and its severity, but also as a criteria of adequacy of therapy. 

Purpose: To investigate the peculiarities of vasculo-endothelial growth factors’ system in physiological pregnancy in dependence on fetal sex.

Material and Methods: We studied 107 women with physiological pregnancy, 52 with male fetuses, 55 with female. We studied the levels of vasculo-endothelial growth factor, placental growth factor, endothelial growth factor, endothelin-1, tumor necrosis factor-a levels in women in 1, 2 and 3 trimesters of pregnancy in dependence on factor “fetus sex”.

Results: We revealed significant differences of these indices in women with male and female fetuses in dependence on gestational age. We detected significant differences in the function of vasculo-endothelial growth factors’ system in dependence on fetal sex, indicating the existence of systemic preconditions to its anatomical and functional heterochronys.

Summary: There is a certain ratio of the absolute levels of the studied polypeptides in physiological pregnancy for each trimester. There were significant differences in their levels of sex of the fetus 

Purpose: To study the features of the blood coagulation system of women at various stages of normal pregnancy, depending on the sex of the fetus.

Material and Methods: Retrospective evaluation of blood coagulation in 259 women with physiological pregnancy in I, II and III trimester with no abnormalities of the blood was conducted. Of these, 116 women had female fetuses (I group), 143 - male fetuses (II group).

Methods: The clinical, clinical laboratory, biochemical. Results: We found that with increasing gestational age the increased activity of coagulative hemostasis was noted in both clinical groups, but the rate of these changes was higher and reached a maximum in II trimester in women with a male fetus, whereas in women with female fetus pace of these changes was less pronounced.

Summary: These results indicate the existence of differences in the «functional behavior» of individual components of the system of hemostasis in various stages of physiological pregnancy. In women with male fetuses we revealed higher coagulation readiness in physiological pregnancy, indicating the tension of coagulation system in this variant of sexual dimorphism. 

Purpose: To study the function of external respiration and its integration with the cardiovascular system in women with different lateral profile asymmetries in perimenopausal period.

Materials and methods: We examined a total of 173 women: 56 in late reproductive (I group), 62 - in premenopausal (II group), and 56 - in postmenopausal (III group) periods. We used Annet’s test, echocardiography, spirography.

Results: We detected the decrease of the efficiency of external breath system in women with ambidekstral phenotype with a predominance of left signs with increasing age, indicating a lower resistance and adaptability of this constitutional subgroups.

Summary: The investigations revealed that the processes of adaptability and resistance in the dynamics of age periods of ontogeny, especially during the «extinction» of the reproductive function is largely modulated by stereoisomerization of female body. 

Purpose: To reveal changes in maternal, placental and fetal circulation after the inhibitor phosphodiesterase-5 (Sildenafil citrate) use in the treatment of placental insufficiency.

Materials and Methods: Based on a randomized double-blinded and placebo-controlled trial, 26 pregnant women with documented placental insufficiency and moderate intrauterine growth retardation at 28-36 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on utero-placental circulation determined by Doppler ultrasound study of the umbilical, fetal middle cerebral arteries and aorta. Cerebro-placental (CPR) and cerebro-aortal ratio (CAR) as the markers of fetal well-being were calculated also.

Results: There was no significant changes in the maternal circulation after Sildenafil use. Pulsatility index in the middle cerebral artery was increased (p<0,05) and in the umbilical artery and fetal aorta it had a tendency to decreasing. There was established a significant increasing of the CPR and CAR values, both of them had a vector to values of an uncomplicated pregnancy.

Summary: We have safely conducted a clinical trial of a drug not routinely used during pregnancy. Sildenafil in the dose 20 mg was well tolerated, with no increase in maternal or fetal morbidity. It was revealed significant improvement in the fetal and placental blood circulation after single dose of Sildenafil use, so it may be a potential drug in the treatment of the placental insufficiency.

Purpose: To study peculiarities of pregnant women somnological status with different type of stereofunctional organization of mother-placenta-fetus system.

Materials and Methods: 291 pregnant women aged 17 to 36 years made the group of physiological pregnancy (147 pers.) And the group with the threatening pregnancy loss was made by 144 women. Results: We revealed stereospecifics of somnological indices, that is more functional vulnerability of left-oriented motherplacenta-fetus system. Key somnological violations: the deterioration of the quality of sleep, snoring, sleep apnea breathing rhythm disturbances, impaired respiratory function.

Summary: At the same time it is important to take into account that neurophysiological substrate that is responsible for central control for the gestational processes is gestational dominanta, determining the full range of central-peripheral relations in a functional system «mother-placenta-fetus», whose role is to maintain the asymmetry of neuro-conductive afferent-efferent effects that prevent abortion. 

Purpose: To study the content of cytokines and agmatine in the development of the placenta in physiological and complicated gestation.

Materials and Methods: 57 women, of which 34 women with physiological pregnancy and 23 women with placental insufficiency were examined. In the early chorion after the abortion and full-term placenta the content of the transforming growth factor (TGF-α and TGF-β), tumor necrosis factor-α (TNF-α) was studied by means of the immune-enzyme analysis. The level of agmatine was studied by capillary electrophoresis.

Results: In the process of normal gestation the increase of the placental production both of the TGF-α and TGF-β was established. During the pregnancy complicated with placental insufficiency and abortion in the first trimester the content of TGF-β and TNF-α was raised, and content of TGF-α was lowered in comparison with the physiological values. For agmatine differently directed changes were revealed: in the early stages of its level was reduced, and by the end of gestation - increased compared with physiological pregnancy.

Summary: The revealed changes of the production processes of the cytokines and agmatine in the placenta may have the pathogenic meaning in the abortion and placental insufficiency development. 

Purpose: To improve the results of treatment of newborns with respiratory distress syndrome (RDS) and perinatal CNS (central nervous system PP), being in critical conditions, by selenium use.

Materials and Methods: blind, controlled, randomized clinical trial application of selenase in newborn babies with RDS and PP CNS with artificial ventilation (AV) was carries out. 76 newborn children being in a critical condition were surveyed. Randomization was carried out by a computer program of a random number generator. In Group I (n = 36), selenase was entered in doses of 10 mg / kg / day intravenously slowly for 10 days, II group (n = 40) - control group.

Results: during the test it was found and statistically proved that the group of children receiving selenase, there is an increase by 1,01 times (р < 0,05) level of hematocrit.

Summary: level increase of hematocrit, promoted decrease (by 1,1 times) frequencies of development of anemias at children of the I group and by that, reduced the duration of carried-out IVL and hospitalization duration. 

Purpose: To study the role of intracellular bioregulators in the formation of placental insufficiency in case of threatened miscarriage in the first trimester.

Materials and methods: 106 women were examined. There were 54 women with the threatened miscarriage in the 6th-12th weeks of pregnancy, 52 women with physiological course of gestation. In the blood serum of these women the amount of follistatin, activin A, glycodelin A, TNF-α, IL-1β and VEGF-A were detected by immunoenzyme method.

Results: The disturbance of the existing correlation between the studied bioregulators providing the trophoblast invasion was determined.

Summary: The imbalance of the indicated regulatory polypeptides results in the change of their interaction causing the disturbance of the ovum nidation and abnormality of the trophoblast invasion that are the bases for formation of placental insufficiency, which creates conditions for the termination of pregnancy. 

Purpose: To study the role of pro-inflammatory and anti-inflammatory cytokines, Toll-like receptors in the pathogenesis of respiratory disorders in full-term newborns.

Materials and methods. The programme of examination included the determination of production of IL-1β, IL-6, IL-8, TNF-α, TGF-β1 and RANTES in bronchoalveolar lavage and blood serum as well as expression of Toll-like receptors on monocytes of peripheral blood in newborn babies with respiratory disorders. Cytokines in the bronchoalveolar lavage, blood serum and expression of Toll-like receptors on the monocytes of peripheral blood were determined in 36 full-term newborns.

Results. The study showed peculiarities of a cytokine profile. In case of respiratory disorders caused by meconium aspiration syndrome (MAS) and respiratory distress syndrome (RDS) high levels of IL-1β, IL-6, IL-8 and TNF–α were revealed in the blood serum and the bronchoalveolar lavage. In the peripheral blood of the newborns with respiratory disorders there was reduced expression of TLR-2 (CD14+CD282+) and TLR-4 (CD14+CD284+).

Summary. The received data indicate an important role of the mechanisms of local protection and inborn immunity in the course and the outcome of respiratory disorders in newborn babies. 

Purpose: to study the level of melatonin and sex hormones in partial light deprivation, donevwith the help of policarbonate lenses, to identify the corrective effect in women with climacteric disorders in perimenopausal period.

Materials and methods: 184 women between the ages of 35 and 60 were studied. Three age groups of healthy women with the second period of maturity and old age ontogenesis, who completely lacked any expression of disregulative processes were formed. And we formed 2 risk groups for the development of dysfunctional changes. We studied somnological and hormonal status, we provided partial light deprivation and polisomnographic investigation.

Results: We showed the normalization of melatonin level and sex hormones in partial light deprivation in women with climacteric disorders. The greatest effect is achieved in women with autonomic form of menopausal syndrome in perimenopausal period compared with menopause.

Summary: Reduced levels of gonadotropic hormones after partial light deprivation, is apparently connected with the blocking effect of increasing blocking effect of melatonin, which level is increased significantly after deprivating light exposure. which depriviruyuschego against light exposure increases significantly. 

Purpose: identify the correlation between antenatal evaluation of fetus and newborn according to cerebral fetal hemodynamic and transcranial cerebral oximetry

Materials and methods. Clinical examination of 90 women before and in 1 termoflabor and 90 newborns. Ultrasound study of fetoplacental complex with Doppler were done to all pregnant women. Study of blood flow were done during functional test wit hapnoe. Cerebral hemodynamic of newborns evaluated by transcranial cerebral oximetry immediately after birth, on the 3rd and 5th days.

Results: There are strict correlation between the Dopplerindices, indices of functional test and indicators of trans cranial cerebral oximetry of newborn.

Summary: Doppler study with functional tests before and in 1 termoflabor allows to assess the state of blood circulation in the vessels of the placenta and fetus objectively, noninvasively and economically available. 

Purpose: Based on the study of clinical features to identify diagnostic criteria for atypical anorexia nervosa (AN) for timely diagnosis and treatment in adolescent girls with oligo-amenorrhea.

Materials and methods: I group - 18 patients with atypical AN, II group - 22 patients with a diagnosis of typical AN. The age of both groups 16 (18; 14) years. The body mass index I of group - 14,55 (17,34; 10,2), II - 15,6 (17,5; 11,6). Control group - 20 teenage girls.

Conducted clinical-psychopathological, experimental psychological research, psychometric scaling. Results: differences in the typical and atypical clinic AN at different stages of the disease, higher efficiency of treatment was found in patients with typical AN.

Summary: needs further search of objective criteria for atypical AN timely diagnosis and differential diagnosis of AN with other diseases associated with underweight and oligo-amenorrhea. 

Purpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.

Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group consisted of 26 clinically healthy newborns. The content of pro-and anti-inflammatory cytokines and chemokines (IFN-γ, IFN-α, IL-12, IL-4, MCP- 1) expression of TLR-2 on monocytes of peripheral blood, frequency polymorphism of Arg753Gln TLR-2 gene.

Results: Found that the criterion of herpes generalized infection is reduced number of monocytes expressing TLR-2 gene polymorphism Arg753Gln TLR-2, which is associated with a reduced content of IFN-α, IL-12 and IFN-y in the serum.

Summary: The development of generalized herpes infection in newborns occurs against violations of the mechanisms of the innate immune response. 

Purpose: improving the efficiency of complex treatment of threatened abortion.

Materials and Methods: The study involved 299 primigravidas. The I clinical group consisted of 78 women with threatened miscarriage receiving combination therapy (standard medication and acupuncture). The II clinical group consisted of 76 women receiving combined medication and acupuncture to our improved method. In the III clinical group - 71 women with threatened miscarriage, which received only standard medical therapy. In the IV (control group) there were 74 pregnant women with physiological pregnancy.

Results: It has been proven that the lateral stimulation of biologically active points of acupuncture taking into account the factor of placental laterality in the utero-placental-fetal complex initiate functional processes accompanied by an increase right asymmetry of utero-placental blood flow and uterine activity, and improvement of the fetus condition.

Summary: We proved that in unilateral acupuncture impact to the placenta, processes of functional symmetry in the utero-placental-fetal complex in women with threatened termination of pregnancy are replaced by functional asymmetry of processes that improve the condition of the fetus 

Purpose: To substantiate the necessity of personality-centered psychocorrective program of rehabilitation for the patients, who underwent critical obstetric conditions that nearly ended in fatal outcome (“near miss”).

Materials and methods: 85 women, who underwent critical obstetric conditions and had psychotraumatic experience of the first labor (PTEL) with different variants of reproductive losses, were examined. Determination of socio-psychological profile, monitoring of gestation course.

Results. The course and outcome of pregnancy in the group of patients with the loss of fetus, but with the preservation of a reproductive function, showed high clinical efficiency of the performed psychocorrective program of rehabilitation together with obstetric monitoring based on the strategy of perinatal risk.

Summary. The determination of socio-psychological profile of the patients, who underwent critical obstetric conditions, specifies the orientation of the personality-centered psychotherapeutic program, which reduces negative consequences of psychotraumatic experience of the first labor. Optimization of the relation of psychogestational dominant types in the group of patients, who preserved the reproductive function, forms favourable attitude to realize it and assists in successful termination of wanted pregnancy. 

Purpose: To reveal peculiarities of neuroendocrine regulationduring psychoemotional stress and their role in the formation of menstrual dysfunction in girls of puberty age with hyperandrogenism.

Materials and methods.In 84 patientsattheageof 15-17 withdifferentmanifestations of hyperandrogenism and in 30 girls of the corresponding age without manifestations of hyperandrogenism the content of basal and stress level of dopamine, androgens, gonadotropic hormones and sex steroids in blood was studied in the course of mild intellectual and emotional stress.

Results: Considerable differences in the level of basal and stress dopamine in the patients with hyperandrogenism in comparison with control group were revealed. In the girls with hyperandrogenism and menstrual disorders as compared to the patients without menstrual dysfunction more greatly expressed disorders of dopamine secretion were observed; they manifested themselves in the form of reliable increase in its basal level as well as reliable change in its secretion in response to the caused stress. A reliable direct correlation of the dopamine level with the excess secretion of adrenal androgens, adrenocorticotropic hormones and luteinizing hormones, and inverse correlation – with the level of estradiol were determined that indicated pathogenetic connection between stress hormones and a number of components of neuroendocrine regulation of reproductive system.

Summary: The results of the conducted research confirm an important role of neuroendocrine regulation disturbances during stress in the genesis of ovarian dysfunction formation in case of hyperandrogenic syndrome. 

Purpose. To develop a method of prediction of primary uterine inertia on the basis of study of cytokine and vasoactive bioregulator content dynamics.

Materials and methods. The material for the research was blood of women taken in the end of gestation (38-40 weeks) and also in the I period of delivery over time from 23 women with physiological act of delivery and from 19 – with uterine inertia.

Results. By primary uterine inertia there is an increase of relaxin production by 2 times and a decrease of TNF-α production: before delivery – by 1.5 times, during delivery – by 2 times, relative to the data by physiological delivery. Differently directed changes of TGF-β1 and IL-1β content – increase of the first one and decrease of the second one – are one of the reasons of low generation of nitric oxide as a result of reduction of NO-synthase activity under the action of these cytokines. High level of relaxin neutralizes the endogenous oxytocin action and the decrease of TNF-α and nitric oxide production causes changes in the content of intracellular calcium in myometrium cells.

Summary: The detected character of the intracellular regulation disturbance of the uterus contractive activity is a basis for the development of uterine inertia. 

Purpose: To study the activity of free radical processes and anti-radical defense enzymes in the serum of women with miscarriage, as well as the effect of information drug serum of women said the contingent (in the experiment).

Materials and methods: Blood serum of 48 women in the first trimester of pregnancy was studied. To assess the state of free radical oxidation the following indicators used: the level of nitric oxide (NOx), peroxynitrite, NO-glutathione, NO-tyrosine and the activity of catalase.

Results: The coefficient of peroxynitrite / NO-tyrosine was calculated. Also the data on the impact of information products (IP) on free radical processes in blood serum of women with high-risk pregnancies is contains.

Summary: The coefficient (peroxynitrite / NO-tyrosine) can be used as a diagnostic criterion of threatened abortion and evaluating the effectiveness of treatment of pregnancy complications. 

Purpose: To estimate the efficiency of the ultrasound diagnosis of postpartum vaginal hematoma in women with varicose veins of the lower extremities

Materials and Methods: 120 women with varicose veins of the lower extremities were examined. In 2 hours after birth for women was conducted transperineal ultrasound - research by vaginal and perineal ultrasound scanner PHILLIPS HD- 11.

Results: Vaginal hematoma was detected in 31 (25.8%) women , and only 10 (8 %) had a damage of integrity of the mucous membrane. The study found that vaginal hematoma size 10,1±3,6 cm at the beginning of the formation can be asymptomatic , which may cause underestimation of the total blood loss in women with postpartum hemorrhage due to a variety of other competing causes.

Summary: The use of analgesia in labor hinders timely diagnosis of postpartum hematomas of vulva and vagina. 

Purpose. The study of immunological mechanisms of hypoxic-ischemic brain damage of varying severity in infants born to mothers with placental insufficiency.

Materials and methods. A clinical and laboratory examination of 58 pregnant women with placental insufficiency in the period 38-39 weeks of pregnancy. The subjects were divided into subgroups: 1a - perinatal CNS lesions with an average degree of severity, clinically detectable at birth (n = 31), 1b - perinatal CNS damage with mild severity, clinically detectable at 1 month after birth (n = 27). The control group consisted of patients with physiological pregnancy and childbirth (n = 19).

Results. It was revealed that the criterion of hypoxic-ischemic central nervous system in newborns is to increase the mother’s blood level of CD16 + NK-cell activation markers of T-cell CD69 +, CD25 +, apoptosis markers CD95 +, AnnexinV +, AnnexinV + PI +, shift the cytokine balance in favor of pro-inflammatory cytokines ( TNF-α, IL -6, IFN-γ), both in serum and amniotic fluid.

Conclusions. The development of hypoxic-ischemic brain damage in newborn infants of mothers with placental insufficiency occurs against violations of the mechanisms of immune response.

Purpose: identify changes in the composition of cytoplasmic and membrane proteins of syncytiotrophoblast during placental insufficiency (PI).

Materials and methods: we examined 64 women, the study group consisted of 34 patients with PI, a control group of 30 women with physiological pregnancy. Analysis of proteins was performed using a one-dimensional electrophoresis and gelchromatography.

Results: carried out researches have allowed to establish in PI reliable differences in the quantity and the mobility of cytoplasmic and membrane proteins of syncytiotrophoblast with different molecular weights. For membrane proteins is also a change in the degree solubilize various detergents.

Summary: detected modification of the composition and properties of proteins syncytiotrophoblast expands our understanding of the molecular mechanisms of development of PI. 

Purpose: to determine the diagnostic value of Doppler velocimetry with reference to neurospecific compounds during the early neonatal period depending on the delivery management.

Materials and methods: 65 pregnant women and newborns were examined. They were retrospectively divided into three clinical groups formed according to neonatologists`s final diagnosis in newborns. Before delivery pregnant women had Doppler velocimetry.

Results: by progressing hypoxemia there is a dilation of the medial cerebral artery of the fetus resulting in the increase of oxygenation of brain tissue of the fetus and in the increase of specific markers of neurologic disturbances.

Conclusion: determination of neurospecific proteins in umbilical blood in newborns is an early method of detection of the central nervous system injury permitting to diagnose pathological conditions and prognosticate a delayed manifestation of brain damages on time without reference to the delivery method. 

Purpose: prevention of bacterial complications correction apoptosis of T lymphocytes with human recombinant granulocyte colony-stimulating factor (G-CSF-par).

Materials and Methods: In randomized, controlled, blind clinical study included 69 neonates with respiratory pathology on mechanical ventilation who were born at term 39,2 ± 1,1 weeks, with a mass of 3650 ± 421, Apgar score 2,3±1,1, no clinical signs of infection, containing lymphocytes in early (AnnexinV-FITC + PI-) and late (AnnexinV-FITC + PI +) apoptosis than 9.59% and 0.56% (respectively) distributed in groups: patients I ( n = 39) received G-CSF is a par-10 mg / kg / day intravenously for the first 3 days, in group II (n = 30) par-G-CSF was not given. On admission, for 3-5 days and in the outcome of the disease by ELISA studied the content of G-CSF, FGF, sFas-L; subpopulations of lymphocytes by flow cytometry on a flow cytometer, Beckman Coulter Epics XL (USA).

Results: Statistical analysis of the results confirmed the reduction of the relative amount of lymphocytes activated Fas-receptor (CD95) and lymphocytes repositories early and late apoptosis, increasing stem cells in peripheral blood, elevated levels of FGF and antiapoptogennogo sFAS after administration par-GCSF, decrease the incidence of septic complications.

Summary: Timely correction of apoptosis of T-lymphocytes par-G-CSF is effective and safe profilaktiruet onset sepsis in neonates with respiratory disorders who are on mechanical ventilation. 

Purpose: studying seasonal periodicity of stereoisomerism of uteroplacental complex, the dynamics of body weight of infants, studying the chronostructure of mezorhythms of contractive activity of right and left parts of the uterus.

Material and Methods: We analyzed 2215 pregnancy stories and birth stories retrospectively. We analyzed the pregnancy flow and childbirth peculiarities, weight and growth rates of newborns. the results of mechanohysterographic of the uterus contractive activity, ultrasound investigation was also taken into account.

Results: Duration of seasonal biorhythms Increase in the number of women with uterine activity, both its localized homogeneous forms, and bilateral generalized contractions (typical for preterm labor), occurred every 7 months. . The increase in the number of large children was observed in autumn and winter, in summer more children were born with low birth weight.

Summary: Environmental factors, varying in different seasons of the year, affect functional processes in the various parts of a functional system «mother-placenta-fetus» through the epiphyseal-hypothalamic and central-peripheral relationships, promoting the initiation of uterine activity, accelerating or decelerating the process of maturation of the fetus, and can also influence the periods of preparedness the body for labor and birth character themselves. 

Purpose: To study peculiarities of the clinical profile of patients of reproductive age suffering from external genital endometriosis (EGE).

Materials and methods: Analysis of clinical presentations of the disease and laboratory examination in 96 patients was performed, among them 74 patients had EGE and 22 patients did not have endometriosis.

Results: The data about the type of menstrual cycle, surgical interventions, inflammatory diseases of pelvic organs and venereal infections were presented and the course of this disease was discussed.

Summary: Burdened gynecological history in the form of past inflammatory diseases of pelvic organs and surgical interventions is of importance in the clinical profile of the patients with EGE. 

Purpose: To study the dynamics of production and reception of angiogenic growth factors (epidermal growth factor (EGF), transforming growth factor-b (Smad-4)), to prove the role of a male factor in miscarriage.

Materials and methods: 180 pregnant women (trimester I) divided into 3 clinical groups were included in the research. The material for the research was the blood serum taken in the gestation term of 8-10 weeks of pregnancy.

Results: In case of miscarriage, the expression of the transforming growth factor-b (Smad-4) decreases. In 60% of cases the key role in miscarriages plays the male factor.

Summary: In order to reduce the risk of reproductive losses, it is necessary to recommend couple examination to all patients with recurrent miscarriagefor pregravid preparation.

Purpose: To study the dynamics of production and reception of angiogenic growth factors (epidermal growth factor (EGF), traPurpose: To study the correlation relationships between the parameters of cerebral blood flow measured by Doppler and the saturation of oxygen in brain tissue, determined by the method of cerebral oximetry in healthy infants.

Materials and Methods: The study was conducted in 24 babies born in the maternity ward Institute of Obstetrics and Pediatrics, weighing at least 2500 g., Apgar score 7-10 points at 38-40 weeks of gestation. All children on 1,3,5 day of life was carried cerebral oximetry, blood flow velocity was measured in the cerebral arteries using pulsed Doppler.

Results: Statistical analysis of the results confirmed the presence of correlations between cerebral oximetry and pulsed Doppler blood vessels of the brain.

The authors of the article define the tasks of the Training Centre of Postgraduate Education of Rostov Scientific and Research Institute of Obstetrics and Pediatrics, summarize the results of its activities for the last three years and also outline the prospects for future development. It is concluded that there is a necessity of further methodical work to improve staff qualification as the prospects of health care development and the problems of medical aid quality to a considerable extent depend on the professional level and quality of training of the medical staff representing the main health care resource. 

One of priority tasks of modern health care is to provide people with high-technology help. The problem of practical training of the staff to work with high-technology equipment is very important. Modern requirements for practical training of a physician dictate revision of training ideology. Global tendencies towards perfection of training technologies place emphasis on wide introduction of virtual simulators and manikins. Traditional system of practical training in the sphere of health care has some shortcomings. Acquisition of practical skills is realized on patients with the risk to their health. The way, which has been used for many years by our western colleagues – development of simulation centres, inevitably opens in front of our health care.