Purpose: to prove the appointment of essential phospholipids in the metabolic syndrome. 1 molecule of phospholipid dissolves the 3 molecules of cholesterol and removes it from the body. Moreover, phospholipids are able to extract cholesterol from atherosclerotic plaques and cell membranes. In combination with high-density lipoprotein cholesterol phospholipids are removed from the plaques by 50% more cholesterol than without phospholipids. Phospholipids and cholesterol is carried out «maintenance» of cell membranes. Cholesterol is transported to a place of repair only as a complex with molecules of phospholipids. Thus, phospholipids are have not only the hepatoprotective, but lowering cholesterol action, which makes their assignment reasonable in patients with metabolic syndrome.

The enzymes exosecreted by digestive glands, especially proteinases have not only digestive but signal role. The role is realized by means of regulatory peptide formation, stimulation and inhibition of their release, stimulation of special proteinase-activated receptors of digestive organs and adaptation their digestive and protective function. The enzymes endo-secreted by digestive glands have the same role. The examples of complex enzyme regulation of digestive and non-digestive organ functions in normal and pathologic condition were demonstrated.

Last decade heightened interest to innate immunity in different areas of medicine is observed. In article the known data for today about a role of factors of innate immunity (toll-receptors) in pathological process is reflected, the basic cascade of the reactions started by means of TLR is displayed, the role pattern-recognition receptors is underlined at inflammatory bowel diseases.

The problem of inflammatory bowel disease draws constant attention not only of gastroenterologists but also surgeons - coloproctologists and other doctors. These related to the growing incidence of this pathology in the world, as well as the diversity of clinical manifestations, including severe extraintestinal manifestations and complications, which in clinical practice, faced not only gastroenterologists. In most cases, inflammatory bowel disease leads to permanent disability cases, which makes this problem not only medical but also socially relevant.

Extraintestinal manifestations and complications of inflammatory bowel disease currently represents one of the most mysterious phenomenon in gastroenterology. Special interest is caused damages of liver, biliary system and pancreas, as constituent organs of the digestive system and first responders not only to inflammation of the intestinal mucosa, but also for medicines taken by patients for induction and maintenance of remission.

Purpose: Estimation of clinical efficiency adaptole а in correction of an asthenic syndrome at patients with a syndrome of angry intestines (IBS).

Materials and Methods: 52 patients (38 women and 14 men) with a syndrome of angry intestines (IBS) with presence of various psychopathological frustration of the neurotic register have been included in research. The age of patients varied from 28 till 40 years. Patients received a preparation adaptole in a dose 0, 5 г 2 times a day irrespective of food intake. Course of treatment 1 month. Appointment of accompanying psychotropic preparations was not supposed. The diagnosis is verified by modern clinic-tool methods of research. The psychometric research was conducted.

Results: The analysis of biographical particulars has shown, that patients had expressed disturbing frustration. In group of patients with constipation variant IBS high level personal was observed and an average level of situational, that correlates with results of uneasiness on scale Sheehan, the test of color elections Lusher. Clinically authentic infringements of nervous vegetative system are found out in patients with IBS. By the end of a 3-week course of application adaptole а practically has completely disappeared somatization alarm displays, painful sensations and clinical symptoms somatovegetative were stopped to dysfunction, dissomnitice frustration, antivitale experiences. In the course of carrying out of clinical research insignificant by-effects of therapy have been found out.

Summary: Аdoptole renders moderated tranquilizing influence and practically does not cause by-effects. The preparation can have metabolic an effect, normalising the various metabolic processes broken by stress, besides, аdoptole can influence functioning neurosensitive systems.

Purpose: To evaluate the prevalence and the role of undifferentiated connective tissue dysplasia in the pathogenesis of recurrent erysipelas.

Materials and Methods: This retrospective study includes patients with primary and recurrent erysipelas who checked up during a period of 24 months. Patient’s level of free hydroxyproline in blood serum was checked by the colorimetric method of T.P. Kuznetsova.

Results: The number of dysembryogenetic stigma in patients with recurrent erysipelas was significantly more than in patients with primary erysipelas. The highest level of hydroxyproline was in patients with recurrent erysipelas.

Summary: Patients with erysipelas are characterizes by connective tissue dysplasia. In patients with erysipelas identified changes in the indicators of collagen metabolism, indicating their partial degradation. Increased levels of free hydroxyproline in patients’ blood with erysipelas reflects the destruction of tissue and cellular structures of skin as a result of acute bacterial inflammation.

Purpose: To determine prevalence and evaluate the risk of hypertensive nephropathy in patients with hypertension.

Materials and Methods: Based on the city polyclinic № 16 Rostov-on-Don and the Center for Restorative Medicine and Rehabilitation, the mines was carried out screening of patients with hypertension. The study included 330 hypertensive patients without chronic kidney disease in history, of which 303 (91.8%) patients were male, 27 (8.2%) patients – women.

Results: It was found that not all clinical and laboratory parameters are affecting the risk of kidney damage in patients with high blood pressure.

Summary: Hypertension leads to irreversible renal disorders, assessment of risk is an integral part of the MT treatment activities conducted in these patients.

Purpose: To prove the efficacy of Ursodeoxycholic acid Urdoksa as hepatoprotector in patients with cardiac fibrosis of the liver.

Materials and Methods: We examined 30 patients before and after a month’s course of therapy with 500 mg per day.

Results: All patients had statistically significant positive clinical dynamics in the form of reducing of the intensity of pain in the right upper quadrant, symptoms of dyspepsia, flatulence. Itching decreased or stopped in all patients, celebrating its pretreatment. There was not adverse events in any case. On biochemical parameters observed decrease ALT levels by an average of 32%, AST by 24%, total bilirubin level decreased by 54%.

Summary: Our studies confirm the high clinical efficacy, good tolerability Urdoksa and quality of life in patients with cardiac fibrosis of the liver, which allows him to recommend this group of patients.

Purpose: To study activity metal-dependent of enzymes at deficiency of micro-elements with antioxidant properties in a food allowance 2 types sick of a diabetes.

Materials and Methods: It is surveyed 20 patients diabetes 2 type. Control group have made 20 Health volunteers. Defined the maintenance in a diet microelements. Defined the maintenance in plasma of enzymes antioxidant protection.

Results: Data is obtained about condition antioxidant system at Health volunteers and 2 types sick of diabetes.

Summary: The way of diagnostics of deficiency of microelements on the basis of the analysis of an actual food allowance is cheap and can be used at a stage of out-patients diagnostics for revealing of groups of risk of persons with somatic pathology caused at deficiency of microelements.

Purpose: To improve the detection and optimization of prevention of early cancers of the stomach through the development of endoscopic methods of diagnosis and treatment of dysplastic changes in gastric mucosa.

Materials and Methods: In accordance with the intended purpose were examined 13 255 patients with atrophic gastritis. Dynamic observation of patients included chromoscopy, magnifikatsionnoe endoscopic, endoscopic.

Results: Polypoid masses were identified in 151 case (67.4%), flat lesions of the mucous - 62 (27.7%), erosion - 11 (4.9%) (Fig. 4). The most common dysplastic changes of gastric mucosa were observed in the antral - 146 cases (65.2%), rarely in the stomach area and subkardii - 78 (34.8%) cases.

Summary: The dynamic observation of patients at risk for the development of gastric lesions preneoplasticheskih allows for timely diagnosis and minimally invasive treatment preneoplasticheskie changes and early cancer of the stomach.

Purpose: To conduct a comparative analysis of the effectiveness of basic medical and comprehensive (basic and biofeedback therapy) treatment of IBS on the dynamics of clinical symptoms.

Materials and Methods: In the current 2005 to 2009 study involved 75 women aged 18 to 40 years diagnosed with «Irritable bowel syndrome without diarrhea». The first group consisted of patients with IBS who received standard treatment (pinaveriya bromide, mebeverine hydrochloride, polifenilglikol, lactulose). Patients of the second group additionally received a course of biofeedback therapy on agriculture «INTEKS». The third group consisted of patients who have not completed a course biofeedback therapy.

Results: No significant differences in clinical symptoms of disease in groups of patients with IBS before treatment were found. The best indicators were sick, conducted an additional course of biofeedback therapy.

Summary: The combined therapy of IBS, consisting of standard medical therapy and biofeedback, has a higher efficiency in the long run, when the effect of a course of treatment is not symptomatic.

Purpose: To establish the dependence of some leading indicators spirogram on the type of portal blood flow (PBF) in patients with liver cirrhosis (LC).

Materials and Methods: Leading indicators of pulmonary ventilation and the most significant parameters were determined from the PC CPU 161 patients (94 men and 67 women aged from 30 to 70 years).

Results: The average values of at different PBF were generally reducedcompared with the control group, and revealed statistically significant differences for VC, FVC and MOS50, MOS25 that reflect bronchial patency in the bronchi of medium and small caliber.

Summary: The state of pulmonary ventilation in patients with LC is associated with the types of PBF, reflecting the nature of the restructuring of hepatic portalhemodynamics.

Purpose: Show the ability to handle the stump of the duodenum using the entire thickness of the round ligament of liver

Materials and Methods: For treatment of the stump of the duodenum during surgery for gastric resection with Billroth II penetrating into the head of the pancreas or liver gates ulcers developed a method of providing for the imposition of two rows of stitches with the capture of the second series of the entire thickness of the roundligament of liver.

Results: In this method, carried out processing of the stump of the duodenum in 12 patients with penetrating into the head of the pancreas or liver gates duodenalulcers

Summary: When performing gastrectomy Billroth II on penetrating into the head of the pancreas or liver gates ulcers can process duodenal stump using he entire thickness of the round ligament of liver

Purpose: To prove rational methods of treatment of patients with diverticulosis of the colon and liver comorbidity by studying of some pathogenetic mechanisms of formation of disease and features of its current.

Material and Methods: 97 patients with diverticular disease of colon from which at 35 involving in pathological process of a liver by an original technique (the Federal patent of Russia № 2119168 has been diagnosed) are surveyed. Patients have been divided on two groups: the first group (10 patients) received traditional treatment, in the second group (25 patients) treatment spent by the developed technique.

Results: At diverticular disease of colonin 87,63% of cases infringement of function of a liver at what is more often it meets at aged people from 45 till 70 years comes to light. It is established that the pathogenetic interrelation of frustration of function of a liver and a thick gut at diverticular is caused by infringement of local hemodynamics, and also activation of processes peroxidation oxidations of lipids (FLOOR).

Summary: Combined application antioxidatic positive therapies and hepatoprotectors against the standard therapy, leads to current improvement diverticulosis thick intestine at 72,6% patients.

Purpose: To evaluate the clinical efficacy and safety Thiotriazoline in patients with acute alcoholic hepatitis.

Materials and Methods: The study included 67 patients with acute alcoholic hepatitis. Randomized patients were divided into two groups - primary and compared. Patients of the group (n = 35) received traditional treatment, in additionto which was connected hepatoprotector Thiotriazoline.

Results: showed improvement of clinical, biochemical and instrumental parameterswhile taking the drug Thiotriazoline.

Summary: The efficacy of treatment as measured by a combined index of overall effectiveness, the drug is comparable to that tiotreazolin with basic therapy, including the traditionally used hepatoprotectors.

Purpose: To study typical patterns of variability of the anatomical structure of the gall bladder.

Materials and Methods: Somatotype of 310 adolescents of both sexes without pathology of the digestive system by the method of L. Rees, H.J. Eysenck, followed by ultrasound of the gallbladder. Sonography of the gallbladder was performed according to standard procedure.

Results: It was established that the average values of all parameters studied in boys was significantly higher than that of girls.

Summary: The size and shape of the gallbladderdepends on the physical type of the subject.

The problem of chronic kidney disease is not only medical but also social and economic importance. Since these diseases annually kill millions and lead to severe complications associated not only with disability but also the need for high-cost treatment.

Therefore, an important aspect of therapy in patients with chronic kidney disease is to prevent development and progression of renal failure. Consequently, a major focus of prevention is to conduct renoprotektivе therapy. In connection with what is necessary to develop new therapies aimed at the basic pathophysiological mechanisms of development of nephropathy. One of the new directions of development in renoprotektivе therapy is the use of the drug in the practice of Sulodexide. Considering the basic properties of the drug, currently based on the Nephrology department conducted a clinical study of the properties of Sulodexide and already received the first clinical cases of the positive effect of the therapy Sulodexide. Consequently, we can already assume that this drug has renoprotektivе action.

The pathogenesis of secondary hyperparathyreosis (SH) is based on three links. First, that may be a decrease of ionize calcium level and a rise of phosphorous level. Second, that may be a diminution of calcitriolґs synthesis. Third, and just as important as the other two, that may be a decrease of calcitriolґs effect for work of parathyreoid glands.

The clinical presentation include kidney disease clinical manifestation, ostoedystrophies, metastatic calcification of tissues and vessels, pruritus and pseudogoat syndrome.

The most important laboratory and instrumental diagnostic criterions are: the level of parathyrin, calcium, calcitriol, phosphorous; ultrasonic scanning, computer tomography, scintigraphy of parathyreoid glands; bone’s X-ray examination and densitometry.

Prevention and treatment of SH presuppose hypophosphatic ration, phosphatbinders, vitamin D and him active metabolites and calcimimetics.

The Rostov Center of Hyperparathyreosis was found in 01. September. 2010 in the nephrologic department of the Rostov State Medical University. The main of the centerґs work is to render specialized competent medical aid to patients with nephrology diseases, which associated with supersecretion of parathormone and resulting complications.

Increase of a contingent of patients with atherosclerotic lesions of visceral branches of abdominal aorta, serious consequences of circulatory injuries of the gastrointestinal tract during the last years, the appeared possibilities of early diagnostics by noninvasive methods of research dictate necessity of rendering of timely medical aid to patients with ischemic lesions of an abdominal cavity organs. Difficulties of diagnostics of erosive-ulcer lesions of a stomach and duodenum of ischemic origin are connected with an insufficient estimation and wrong interpretation of the data of a clinical picture, absence of awareness of doctors about considerable frequency of occurrence of this pathology, especially among persons of the senior age groups. The doctor, facing with ischemic lesions of gastroduodenal localization in elderly and senile age is guided by traditional concepts of etiopathogenesis of erosive-ulcer lesions, unreasonably excluding from this number a vascular pathology. The publication of the given materials based on the data of the literature and own supervision can render the essential help to practical doctors in early diagnostics and treatment of this category of patients.

Treatment of patients NFDL in Municipal clinic allows comprehensive treatment of this disease on an autpatient basic, which leads to improved well-being of patients, normal of biocamical parameters.