CYTOKINES AND FUNCTIONAL RESERVES OF ENDOTHELIUM IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION
https://doi.org/10.21886/2219-8075-2013-2-102-105
Abstract
Purpose: To evaluate the cytokine profile and endothelial functional reserve in patients with ref-teristic hypertension.
Materials and methods: 42 patients with refractory hypertension (30 men and 12 women), control group - 32 patients. The average age of 59,4 ± 1,12 years. The metabolic stability of endothelium in patients evaluated in the study are pharmacologically tentsiiruemoy endothelium-dependent vasodilation (EDVD). The work has been defined as the original content in the blood of proinflammatory and anti-inflammatory cytokines.
Results: It was found that in 66.7% of cases, metabolic stability endothelial cells to oxidative stress product is preserved, and in 33.3% of a loss of resistance to cytotoxic products.
Conclusion: In patients with refractory hypertension without metabolic stability of endothelium-dependent vasodilation Leah ability vessels progressively reduced, which is associated with the increase in the level of pro-inflammatory cytokines in the blood.
About the Author
A. V. Safronenko
Rostov State Medical University
Russian Federation
Russian Federation
Department of Pharmacology and Clinical Pharmacology
344022, Rostov-on-Don, Nakhichevan 29References
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Review
For citations:
Safronenko A.V. CYTOKINES AND FUNCTIONAL RESERVES OF ENDOTHELIUM IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION. Medical Herald of the South of Russia. 2013;(2):102-105. (In Russ.) https://doi.org/10.21886/2219-8075-2013-2-102-105
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