REGIONAL GENOTYPES OF HELICOBACTER PYLORI IN CHILDREN WITH GASTRODUODENAL PATHOLOGY IN THE REPUBLIC OF BASHKORTOSTAN
https://doi.org/10.21886/2219-8075-2013-2-94-97
Abstract
Purpose: To investigate regional variants of H. pylori genotypes.
Materials and methods: Regional variants of H. pylori genotypes have been studied (Cag A, Vac A, Ice A, Bab A2) in clinical strains of H. pylori, obtained from 91 paediatric patients (mean age 14.3±1.6 years), with gastroduodenal pathology in the Republic of Bashkortostan.
Results: Marker of pathogenicity island Cag A was revealed in 42 patients (46.1%), Bab A2 – in 31 (34%), Vac A genotype S1 - in 59 (64.8%) and S2 - in 32 (35.2%), Ice A1 - in 72 (79.1%), Ice A2 - in 19 (20.9%).
Summary: Among the patients with peptic ulceration, H. pylori strains, carrying markers of pathogenicity island Cag A / Vac AS1 in combination with Bab A2 were detected significantly more often.
About the Authors
A. A. Nijevitch
Bashkirian State Medical University
Russian Federation
Russian Federation
Hospital Pediatrics Department
3 Lenina st., Ufa, 450000, Bashkortostan
E. N. Akhmadeeva
Bashkirian State Medical University
Russian Federation
Russian Federation
Hospital Pediatrics Department
3 Lenina st., Ufa, 450000, Bashkortostan
E. S. Kuchina
Bashkirian State Medical University
Russian Federation
Russian Federation
Hospital Pediatrics Department
3 Lenina st., Ufa, 450000, Bashkortostan
M. M. Tuygunov
Bashkirian State Medical University
Russian Federation
Russian Federation
Department of Microbiology
3 Lenina st., Ufa, 450000, Bashkortostan
V. U. Sataev
Bashkirian State Medical University
Russian Federation
Russian Federation
Pediatric Surgery Department
3 Lenina st., Ufa, 450000, Bashkortostan
References
1. Бухарин О.В., Кириллов В.А. О некоторых механизмах персистенции Helicobacter pylori. Журн. микробиол. 2002, 2:89- 94.
2. Исаков В.А. Молекулярно – генетические основы патогенности H. pylori. Росс. журн. гастроэнтерол., гепатол., колопрок- тол. 2002,12,6:82-85.
3. Umit H., Tezel A., Bukavaz S., et al. The relationship between virulence factors of Helicobacter pylori and severity of gastritis in infected patients. Dig. Dis. Sci. 2009, 54(1):103-10.
4. Мишкина Т.В., Александрова В.А., Суворов А.Н. Влияние различных генотипов H. pylori на клинико – эндоскопические и морфологические проявления хронических гастродуоденальных заболеваний у детей и подростков. Педиатрия 2007, 86,5:28-32.
5. Alarcon T., Martinez M., Urruzuno P. et al. Prevalence of Cag A and Vac A antibodies in children with Helicobacter pylori – associated peptic ulcer compared to prevalence in pediatric patients with active and non – active chronic gastritis. Clin. Diagn. Lab. Immunol. 2000,7,5:842-844.
6. Kusters J.G., Arnoud H.M. van Vliet, Kuipers E.J. Pathogenesis of Helicobacter pylori Infection. Clin Microbiol Rev. 2006 July; 19(3): 449–490.
7. Kato S., Sugiyama T., Kudo M. et al. Cag A antibodies in japanese children with nodular gastritis or peptic ulcer disease. J. Clin. Microbiol. 2000;28,1:68-70.
8. Tham K.T., Peek R.M.Jr., Atherton J. et al. Helicobacter pylori genotypes, host factors and gastric mucosal histopathology in peptic ulcer disease. Hum. Pathol. 2001,32,3:264-273.
9. Насыбуллина Э.Р., Абдулхаков Р.А., Чернова О.А., Горшков О.В., Чернов В.М. Распределение генотипов H. pylori среди пациентов с гастродуоденальной патологией. Эксп. клин. гастроэнтерол. 2004,1(спец. выпуск):126-132.
Review
For citations:
Nijevitch A.A., Akhmadeeva E.N., Kuchina E.S., Tuygunov M.M., Sataev V.U. REGIONAL GENOTYPES OF HELICOBACTER PYLORI IN CHILDREN WITH GASTRODUODENAL PATHOLOGY IN THE REPUBLIC OF BASHKORTOSTAN. Medical Herald of the South of Russia. 2013;(2):94-97. (In Russ.) https://doi.org/10.21886/2219-8075-2013-2-94-97
Views:
397
Email this article 