DYNAMICALLY DETERMINE TOLL-RECEPTORS PATIENTS WITH ULCERATIVE COLITIS
https://doi.org/10.21886/2219-8075-2013-0-2-20-33
Abstract
Purpose: Dynamic determination of TLR 2,4,6 in patients with relapsed UC with an assessment of the use of indicators characterizing the state of TLR, as markers of remission.
Materials and Methods: The study included 86 patients with recurrent UC, 39 of which have reached clinical and endoscopic remission. TLR expression on peripheral blood monocytes was determined in immunofluorescence test using monoclonal antibodies to TLR2 (СD14+CD282+), TLR4 (СD14+CD284+) и TLR6 (СD14+CD286+), conjugated with FITC (fluorescein isothiocyanate) and PE (phycoerythrin) - labeled (HyCultbiotechnology, Holland).
Results: number of monocytes expressing TLR 2,4,6 increased activation of the inflammatory process, with remission rates expression of TLR 2,4,6 not different from those in the control group.
Conclusion: you can use the number of monocytes expressing TLR 2,4,6 as a marker of remission.
About the Authors
L. N. Mamedova
Rostov State Medical University
Russian Federation
Russian Federation
Department propaedeutic of internal medicine
29 Nakhichevansky st., Rostov-on-Don, 344022G. N. Tarasova
Rostov State Medical University
Russian Federation
Russian Federation
Department propaedeutic of internal medicine
29 Nakhichevansky st., Rostov-on-Don, 344022E. A. Chumakova
Semashko «Hospital №1»
Russian Federation
Russian Federation
City immunological laboratory
105, Voroshilovsky av., Rostov-on-Don, 344000I. G. Stolyarova
Rostov State Medical University
Russian Federation
Russian Federation
Department propaedeutic of internal medicine
29 Nakhichevansky st., Rostov-on-Don, 344022References
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For citations:
Mamedova L.N., Tarasova G.N., Chumakova E.A., Stolyarova I.G. DYNAMICALLY DETERMINE TOLL-RECEPTORS PATIENTS WITH ULCERATIVE COLITIS. Medical Herald of the South of Russia. 2013;(2):90-93. (In Russ.) https://doi.org/10.21886/2219-8075-2013-0-2-20-33
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