CLINICAL AND DIAGNOSTIC CRITERIA FOR OXIDATIVE STRESS OF NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME AND ANTIOXIDANT THERAPY WITH SELENASE®
https://doi.org/10.21886/2219-8075-2013-2-55-59
Abstract
Purpose: improvement of the results of treatment of the newborns with the respiratory distress syndrome (RDS) and perinatal defeat of TsNS (TsNS software), being in critical conditions, by using selenium.
Materials and methods: a randomized controlled blind clinical test of application selenase at newborns with RDS and perinatal defeat of the CNS, being on the artificial ventilation of lungs (AVL) is carried out. 76 infants being in the critical condition and 30 healthy infants, who have made group of comparison, were surveyed. During the research a comparative analysis of the intensity of processes of the lipid peroxidation (LPO) and antioxidant system of protection (AOS) in 3 groups.
Results: during the test it was revealed and statistically proved that the group of children receiving selenaz(at a dose of 10 mkg / kg / day slowly intravenously within 10 days), the level of glutathione peroxidase (GSH-Px-3) serum has increased by 1.13 time (from the moment of receipt).
Summary: the increase of GSH-Px-3 promoted AOS strengthening that provided in the subsequent more rapid transition to independent breathing (IVL termination), and thus, reduce the duration of hospital stay.
About the Authors
L. F. Dolotova
Rostov Research Institute of Obstetrics and Pediatrics
Russian Federation
43/38/2 Mechnikova st., Rostov-on-Don, 344012
Russian Federation
43/38/2 Mechnikova st., Rostov-on-Don, 344012
V. V. Estrin
Rostov Research Institute of Obstetrics and Pediatrics
Russian Federation
43/38/2 Mechnikova st., Rostov-on-Don, 344012
Russian Federation
43/38/2 Mechnikova st., Rostov-on-Don, 344012
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For citations:
Dolotova L.F., Estrin V.V. CLINICAL AND DIAGNOSTIC CRITERIA FOR OXIDATIVE STRESS OF NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME AND ANTIOXIDANT THERAPY WITH SELENASE®. Medical Herald of the South of Russia. 2013;(2):55-59. (In Russ.) https://doi.org/10.21886/2219-8075-2013-2-55-59
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