GUT MICROBIOTA AND HYGIENE THEORY OF ATOPY
https://doi.org/10.21886/2219-8075-2013-2-25-30
Abstract
The indigenous gut microbiota plays a key role in maintaining homeostasis in gastrointestinal tract. The review is devoted to factors influencing gut microbiota composition, involvement of microbiota in formation of systemic and mucosal immunity, the role of disturbances of microbial community in development of allergic disease.
About the Authors
A. V. Shestopalov
Rostov State Medical University
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
M. A. Shestopalova
Rostov State Medical University
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
E. V. Dudnikova
Rostov State Medical University
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
T. S. Kolmakova
Rostov State Medical University
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
V. A. Chistyakov
Rostov State Medical University
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
Russian Federation
29 Nakhichevansky st., Rostov-on-Don, 344022
References
1. Fujimura K.E., Slusher N.A., Cabana M.D., Lynch S.V. Role of the gut microbiota in defining human health // Expert Rev. Antiinfect. Ther. - 2010. - №8 (4). - P. 435-454.
2. Resta S.C. .Effects of probiotics and commensals on intestinal epithelial physiology: implications for nutrient handling // The Journal of Physiology. - 2009. - № 587. - Р. 4169-4174.
3. Stappenbeck T.S., Hooper L.V., Gordon J.I. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells // Proc. Natl. Acad. Sci. USA. - 2002. - № 99. - Р. 15451-15455.
4. Хавкин А.И., Жихарева Н.С. Коррекция дисбиотических изменений кишечника у детей на современном этапе // Русский медицинский журнал. - 2006. - № 16. - С. 3-6.
5. Хавкин А.И., Бабаян М.Л. Применение пробиотиков в коррекции дисбиотических нарушений кишечника у детей // Русский медицинский журнал. - 2008. - № 16(4). - С. 178-181.
6. Rhee K., Jasper P.J., Sethupathi P. et al. Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues // JEM. - 2005. - № 201 (1). - Р. 55-62.
7. Бондаренко В.М., Мацулевич Т.В. Дисбактериоз кишечника как клинико-лабораторный синдром: современное состояние проблемы. - М.: ГЭОТАР-Медиа, 2007. - 304 с.
8. Ivanov I.I., Littman D.R. Modulation of immune homeostasis by commensal bacteria // Curr Opin Microbiol. - 2011. - №14 (1). - Р. 106-114.
9. Lanning D., Sethupathi P., Rhee K. et al. Intestinal Microflora and Diversification of the Rabbit Antibody Repertoire // The Journal of Immunology. - 2000. - №165. - Р. 2012-2019.
10. Vinderola G., Matar С., Perdigon G. Role of Intestinal Epithelial Cells in Immune Effects Mediated by Gram-Positive Probiotic Bacteria: Involvement of Toll-Like Receptors // Clin. Diagn. Lab. Immunol. - 2005. - №12. - P. 1075 - 1084.
11. Han Y.W., Shi W., Huang G.T. et al. Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium nucleatum adheres to and invades epithelial cells // Infect. Immun. - 2000. - №68. - Р. 3140-3146.
12. Rudney J.D., Chen R., Sedgewick G.J. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells // J. Dent. Res. - 2005. - №84. - Р. 59-63.
13. Inagaki S., Onishi S., Kuramitsu H.K., Sharma A. Porphyromonas gingivalis Vesicles Enhance Attachment, and the Leucine-Rich Repeat BspA Protein Is Required for Invasion of Epithelial Cells by «Tannerella forsythia» // Infect. Immun. - 2006. - №74. - Р. 5023 - 5028.
14. Penders J., Thijs C., Vink C., et al. Factors influencing the composition of the intestinal microbiota in early infancy // Pediatrics. - 2006. - №118 (2). - Р. 511–521.
15. Favier C.F., Vaughan E.E., De Vos W.M., Akkermans A.D. Molecular monitoring of succession of bacterial communities in human neonates // Appl. Environ. Microbiol. - 2002. - №68. - Р. 219–226.
16. Martin R., Langa S., Reviriego C. et al. Human milk is a source of lactic acid bacteria for the infant gut // J. Pediatrics. - 2003. - №143. - P. 754–758.
17. Мазанкова Л.Н., Новокшонов А.А., Майкова И.Д. Микробиоценоз кишечника и иммунитет // Детские инфекции: На- учно-практический журнал Ассоциации педиатров-инфекционистов. - 2007. - Т. 6, №1. - С. 9-12.
18. Лобанова Е.А., Булатова Е.М., Богданова Н.М., Габрусская Т.В. Кишечная микробиота: современные представления // Педиатрия. - 2009. - N 3. - С. 104-110.
19. Macdonald T.T., Monteleone G. Immunity, inflammation, and allergy in the gut // Science. - 2005. - №307. - Р. 1920-1925.
20. Canny G.O., McCormick B.A. Bacteria in the Intestine, Helpful Residents or Enemies from Within? // Infection and Immunity. - 2008. - Vol.76, №. 8. - Р. 3360-3373.
21. McClelland D.B. Peyer’s-patch-associated synthesis of immunoglobulin in germ-free, specific-pathogen-free, and conventional mice // Scand. J. Immunol. - 1976. - №5. - Р.909-915.
22. Johansson-Lindbom B., Svensson M., Wurbel M.A. et al. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant // J. Exp. Med. - 2003. - №198. - Р. 963-969.
23. Papadakis K.A., Landers C., Prehn J. et al. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile // J. Immunol. - 2003. - №171. - Р. 159-165.
24. Tobagus I.T., Thomas W.R., Holt P.G. Adjuvant costimulation during secondary antigen challenge directs qualitative aspects of oral tolerance induction, particularly during the neonatal period // J. Immunol. - 2004. м№172 (4). - Р. 2274-2285.
25. Macpherson A.J. IgA adaptation to the presence of commensal bacteria in the intestine // Curr. Top. Microbiol. Immunol. - 2006. - №308. - Р. 117-136.
26. Campeotto F., Waligora-Dupriet A.J., Doucet-Populaire F. et al. Establishment of the intestinal microflora in neonates // Gastroenterol. Clin. Biol. - 2007. - №31 (5). - P. 533-542.
27. Duchmann R., Kaiser I., Hermann E. et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD) // Clin. Exp. Immunol. - 1995. - №102. - P. 448-455.
28. Jump R.L., Levine A.D. Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease // Inflamm. Bowel Dis. - 2004. - №10. - Р. 462-478.
29. Duchmann R., Neurath M.F., Meyer K. H. zum Buschenfelde. Responses to self and non-self intestinal microflora in health and inflammatory bowel disease // Res. Immunol. - 1997. - №148. - P. 589-594.
30. Mottet C., Uhlig H.H., Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells // J. Immunol. - 2003. - №170. - Р. 3939-3943.
31. Shirai Y., Hashimoto M., Kato R. et al. Lipopolysaccharide induces CD25-positive, IL-10-producing lymphocytes without secretion of proinflammatory cytokines in the human colon: low MD-2 mRNA expression in colonic macrophages // J. Clin. Immunol. - 2004. - №24. - Р. 42-52.
32. Thornton A.M., Donovan E.E., Piccirillo C.A., Shevach E.M. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function // J. Immunol. - 2004. - №172. - Р. 6519-6523.
33. Stagg A.J., Hart A.L., Knight S.C., Kamm M.A. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria // Gut. - 2003. - №52. - Р. 1522-1529.
34. Uhlig H.H., Powrie F. Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses // J. Clin. Invest. - 2003. - №112. - Р. 648-651.
35. Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria // Science. - 2004. - №303. - Р. 1662-1665.
36. Mow W.S., Vasiliauskas E.A., Lin Y.-C. et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease // Gastroenterology. - 2004. - №126. - Р. 414-424.
37. Strober W., Fuss I.J., Blumberg R.S. The immunology of mucosal models of inflammation // Annual Review of Immunology. - 2002. - №20. - Р. 495-549.
38. Kobayashi M., Kweon M.N., Kuwata H. et al. Toll-like receptordependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice // J. Clin. Invest. - 2003. - №111. - Р. 1297-1308.
39. Torok H.P., Glas J., Tonenchi L. et al. Crohn’s disease is associated with a TLR-9 polymorphism // Gastroenterology. - 2004. - №127. - Р. 365-366.
40. Лебедев К.А., Понякина И.Д. Иммунология образраспознающих рецепторов (интегральная иммунология). - М.: Либроком, 2009. - 256 с.
41. Hugot J.P., Chamaillard M., Zouali H. et al. S. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease // Nature - 2001. - №411. - Р. 599-603.
42. Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease // Nature. - 2001. - №411. - Р. 603-606.
43. Berrebi D., Maudinas R., Hugot J.P. et al. Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn’s disease colon // Gut. - 2003. - №52. - P. 840-846.
44. Lala S., Ogura Y., Osborne C. et al. Crohn’s disease and the NOD2 gene: a role for paneth cells // Gastroenterology. - 2003. - №125. - Р. 47-57.
45. Abreu M. T., Fukata M., Arditi M. TLR Signaling in the Gut in Health and Disease // The Journal of Immunology. - 2005. - №174. - P. 4453-4460.
46. Yoo J., Tcheurekdjian H., Lynch S.V., Cabana M., Boushey H.A. Microbial manipulation of immune function for asthma prevention: inferences from clinical trials // Proc. Am. Thorac. Soc. - 2007. - №4(3). - Р. 277–282.
47. Huffnagle G.B. The Microbiota and Allergies/Asthma // PLoS Pathog. - 2010. - №6 (5). - e1000549.
48. Ege M.J., Bieli C., Frei R., et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children // J. Allergy Clin. Immunol. - 2006. - №117 (4). - Р. 817–823.
49. Wegienka G., Havstad S., Zoratti E.M., et al. Regulatory T cells in prenatal blood samples: variability with pet exposure and sensitization // J. Reprod. Immunol. - 2009. - №81 (1). - Р. 74–81.
50. Schaub B., Liu J., Höppler S., et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells // J. Allergy Clin. Immunol. - 2009. - №123 (4). - P. 774– 782.
51. Debarry J., Garn H., Hanuszkiewicz A., et al. Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties // J. Allergy Clin. Immunol. - 2007. - №119 (6). - P. 1514–1521.
52. Aichbhaumik N., Zoratti E.M., Strickler R., et al. Prenatal exposure to household pets influences fetal immunoglobulin E production // Clin Exp Allergy. - 2008. №38 (11). Р. 1787–1794.
53. McKeever T.M., Lewis S.A., Smith C., Hubbard R. The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands general practice database // Am. J. Respir. Crit. Care Med. - 2002. - №166 (6). - Р. 827–832.
54. Penders J., Thijs C., van den Brandt P.A., et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study // Gut. - 2007. - №56 (5). - Р. 661–667.
55. Johnson C.C., Ownby D.R., Alford S.H., et al. Antibiotic exposure in early infancy and risk for childhood atopy // J. Allergy Clin. Immunol. - 2005. - №115 (6). - Р.1218–1224.
56. Thavagnanam S., Fleming J., Bromley A., et al. A meta-analysis of the association between Caesarean section and childhood asthma // Clin Exp Allergy. - 2008. - №38 (4). - Р. 629–633.
57. Kelly D., Campbell J.I., King T.P., et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclearcytoplasmic shuttling of PPAR-γ and RelA // Nat. Immunol. - 2004. - №5 (1). - Р.104–112.
58. Wagner C.L., Taylor S.N., Johnson D. Host factors in amniotic fluid and breast milk that contribute to gut maturation // Clin. Rev. Allergy Immunol. - 2008. - №34 (2). - Р. 191–204.
59. Bollinger R.R., Everett M.L., Palestrant D., et al. Human secretory immunoglobulin A may contribute to biofilm formation in the gut // Immunology. - 2003. - №109 (4). - Р. 580–587.
60. Inoue R., Otsuka M., Ushida K. Development of intestinal microbiota in mice and its possible interaction with the evolution of luminal IgA in the intestine // Exp Anim. - 2005. - №54 (5). - P. 437–445.
61. Rautava S., Walker W.A. Academy of Breastfeeding Medicine founder’s lecture 2008: breastfeeding – an extrauterine link between mother and child // Breastfeed Med. - 2009. - №4 (1). - Р. 3–10.
62. Klaassens E.S., Boesten R.J., Haarman M., et al. Mixed-species genomic microarray analysis of fecal samples reveals differential transcriptional responses of bifidobacteria in breast- and formula-fed infants // Appl. Environ. Microbiol. - 2009. - №75 (9). - Р. 2668–2676.
63. Sjögren Y.M., Jenmalm M.C., Böttcher M.F., et al. Altered early infant gut microbiota in children developing allergy up to 5 years of age // Clin Exp Allergy. - 2009. - №39(4). - Р. 518–526.
64. Шестопалова М.А. Особенности микрофлоры желудочно- кишечного тракта при H.pylori-ассоциированных хронических воспалительных заболеваниях верхних отделов органов пищеварения: автореф. дис. … канд. мед. наук. - Ростов-на- Дону, 2012. - 24 с.
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For citations:
Shestopalov A.V., Shestopalova M.A., Dudnikova E.V., Kolmakova T.S., Chistyakov V.A. GUT MICROBIOTA AND HYGIENE THEORY OF ATOPY. Medical Herald of the South of Russia. 2013;(2):25-30. (In Russ.) https://doi.org/10.21886/2219-8075-2013-2-25-30
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