BIOCENOSIS VAGINA AT THE VERY EARLY PRETERM LABOR
https://doi.org/10.21886/2219-8075-2014-4-90-94
Abstract
Purpose: consideration of the timing of initiation of antibiotic therapy in the identification of pathogenic infekt, schemes and duration of treatment, the appropriateness of antibiotic therapy at very early preterm delivery.
Materials and methods: a total of 111 pregnant women in terms of 22-25 weeks of gestation with the threat of premature birth. Depending on the condition of the vagina biocenosis are divided into three groups: normotsenoz (n = 35), bacterial vaginosis (BV) (n = 40) vaginitis (n = 36). All pregnant women were examined in accordance with the order number 572n Health Ministry. A comprehensive microbiological research. All pregnant at admission was conducted therapy aimed at prolongation of pregnancy leads to: medical protective regime, diet agravatsiey protein tocolytic therapy, normalization of biocenosis of the genital tract.
Results: in pregnant women with threatened preterm birth at 22-25 weeks of gestation duration of pregnancy depend in particular on the state of the biocenosis of the genital tract. Adverse predictors of premature birth is a combination of BV with persistence of Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in the cervical canal pregnant. Enabling correction of biocenosis of the genital tract in the complex therapy aimed at prolongation of pregnancy in women with BV and vaginitis, does not lead to a significant reduction in the incidence of preterm birth.
Summary: conducted correction of biocenosis of the genital tract, including antibacterial therapy, in terms of 22-25 weeks of gestation is not able to reduce the rate of preterm birth, as the process of infection of the membranes is already running. The development of preterm labor depends on the area of infection and membranes.
Materials and methods: a total of 111 pregnant women in terms of 22-25 weeks of gestation with the threat of premature birth. Depending on the condition of the vagina biocenosis are divided into three groups: normotsenoz (n = 35), bacterial vaginosis (BV) (n = 40) vaginitis (n = 36). All pregnant women were examined in accordance with the order number 572n Health Ministry. A comprehensive microbiological research. All pregnant at admission was conducted therapy aimed at prolongation of pregnancy leads to: medical protective regime, diet agravatsiey protein tocolytic therapy, normalization of biocenosis of the genital tract.
Results: in pregnant women with threatened preterm birth at 22-25 weeks of gestation duration of pregnancy depend in particular on the state of the biocenosis of the genital tract. Adverse predictors of premature birth is a combination of BV with persistence of Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in the cervical canal pregnant. Enabling correction of biocenosis of the genital tract in the complex therapy aimed at prolongation of pregnancy in women with BV and vaginitis, does not lead to a significant reduction in the incidence of preterm birth.
Summary: conducted correction of biocenosis of the genital tract, including antibacterial therapy, in terms of 22-25 weeks of gestation is not able to reduce the rate of preterm birth, as the process of infection of the membranes is already running. The development of preterm labor depends on the area of infection and membranes.
About the Authors
V. E. Radzinskiy
Russian University of People’s Friendship
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
A. A. Orazmuradov
Russian University of People’s Friendship
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
V. F. Arakelyan
Russian University of People’s Friendship
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
Russian Federation
Department of Obstetrics and Gynecology with course of Perinatology
References
1. Bolden J.R. Acute and chronic tocolysis /J.R. Bolden // Clin Obstet Gynecol. – 2014. – V.57 (3). – P.568-578.
2. Prince A.L. The microbiome, parturition, and timing of birth: more questions than answers / A.L. Prince, K.M. Antony, D.M. Chu et al. //J. Reprod. Immunol. – 2014. - pii: S0165-0378(14)00035-7. doi: 10.1016/j.jri.2014.03.006.
3. Menard J.P. Bacterial vaginosis and preterm delivery / J.P. Menard, F. Bretelle // Gynecol. Obstet. Fertil. – 2012. - V.40 (1). – P.48-54.
4. Lamont R.F. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis / R.F. Lamont, C.L. Nhan-Chang, J.D. Sobel et al. //Am J Obstet Gynecol.- 2011. – V.205 (3). – P.177-190.
5. Flenady V. Prophylactic antibiotics for inhibiting preterm labour with intact membranes / V. Flenady, G. Hawley, O.M. Stock et al. // Cochrane Database Syst Rev. - 2013. - Dec 5; 12:CD000246. doi: 10.1002/14651858.CD000246.pub2.
6. Donders G.G. Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy / G.G. Donders, K. Van Calsteren, G. Bellen et al. // BJOG. – 2009. - V.116 (10). – P.1315-1324.
7. Тапильская Н.И. Осложненная беременность от ранних до поздних сроков. Наука и практика / Н.И. Тапильская, А.М. Савичева, В.Е. Радзинский // StatusPraesens. – 2014. – № 2 [19] 04. – С. 15-20.
Review
For citations:
Radzinskiy V.E., Orazmuradov A.A., Arakelyan V.F. BIOCENOSIS VAGINA AT THE VERY EARLY PRETERM LABOR. Medical Herald of the South of Russia. 2014;(4):90-94. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-90-94
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