THE ROLE OF CHEMOCINE GENES IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC GLOMERULONEFRITIS
О. N. Novakova,
I. A. Yushina,
E. V. Nekipelova,
M. I. Churnosov,
I. V. Batlutskaya,
N. I. Zhernakova https://doi.org/10.21886/2219-8075-2017-8-3-71-77
Abstract
Objective: to study the association of genetic polymorphisms of chemokines (+1931А/Т ССL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) with arterial pressure in patients with chronic glomerulonephritis.
Materials and methods: the study group comprised 700 people, including 238 patients with chronic glomerulonephritis and 462 controls. When assessing the level of blood pressure, the patients were divided into three groups: with arterial pressure less than 140/90 mm Hg - 84 patients, with arterial pressure from 140/90 to 159/100 mm Hg - 96 patients with arterial pressure more than 160/110 mm Hg - 52 patients. Th e material for the study was DNA samples isolated from whole venous blood by the phenolchloroform extraction method. Th e analysis of the studied polymorphisms was carried out by the method of detection of TaqMan probes by means of real-time PCR.
Results: it was found that a high level of diastolic blood pressure in patients with chronic glomerulonephritis is associated with the molecular-genetic markers GG and CG CCL2 (rs2857657) (p=0,014), the risk factor for the development of severe arterial hypertension during the disease is the allele A CXCL11 (rs4512021) (p=0,04, OR=1,65).
Conclusion: new data on the involvement of A/G CXCL11 (rs4512021) and C/G CCL2 (rs2857657) polymorphisms of chemokine genes in the development of arterial hypertension in patients with chronic glomerulonephritis of the Central Chernozem Region of Russia have been revealed.
About the Authors
О. N. Novakova
Belgorod State University
Russian Federation
Russian Federation
Olga N. Novakova - Lecturer, Ph.D., Department of Medical and Biological Disciplines, Medical Institute
308015, Belgorod, Pobedy str. 85
I. A. Yushina
Belgorod State University
Russian Federation
Russian Federation
Inna A. Yushina - Senior Lecturer, Ph.D., Department of Medical and Biological Sciences, Medical Institute
308015, Belgorod, Pobedy str. 85
E. V. Nekipelova
Belgorod State University
Russian Federation
Russian Federation
Elena V. Nekipelova - Associate Professor, Ph.D., Department of Biomedical Disciplines, Medical Institute
308015, Belgorod, Pobedy str. 85
M. I. Churnosov
Belgorod State University
Russian Federation
Russian Federation
Mikhail I. Churnosov - Head of the Department of Medical and Biological Sciences, Professor, MD, Department of Biomedical Disciplines, Medical Institute
308015, Belgorod, Pobedy str. 85
I. V. Batlutskaya
Belgorod State University
Russian Federation
Russian Federation
Irina V. Batlutskaya - Head of the Department of Biotechnology and Microbiology, Professor, MD, Department of Biotechnology and Microbiology, Institute of Engineering Technologies and Natural Sciences
308015, Belgorod, Pobedy str. 85
N. I. Zhernakova
Belgorod State University
Russian Federation
Russian Federation
Nina I. Zhernakova - Head of the «Medicine and Pediatrics», Professor, MD, Medical Institute
308015, Belgorod, Pobedy str. 85
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Review
For citations:
Novakova О.N., Yushina I.A., Nekipelova E.V., Churnosov M.I., Batlutskaya I.V., Zhernakova N.I. THE ROLE OF CHEMOCINE GENES IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC GLOMERULONEFRITIS. Medical Herald of the South of Russia. 2017;8(3):71-77. (In Russ.) https://doi.org/10.21886/2219-8075-2017-8-3-71-77
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