Free-radical oxidation condition of the patients with infiltrative pulmonary tuberculosis depending on the pathogenetic treatment method
https://doi.org/10.21886/2219-8075-2017-8-2-46-53
Abstract
Objective: to assess the impact of the methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide medication on the free-radical oxidation processes and the possibility of its use as a multifunctional mean of pathogenetic tuberculosis therapy. Material and methods: a comparative analysis of treatment efficiency, clinic-laboratory data, and free-radical oxidation indices of 50 patients with active pulmonary tuberculosis, which obtained methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide and a standard pathogenetic therapy, was carried out. Results: a decrease in the frequency and severity of destruction of lung tissue, the cessation of bacterial release, rapid resolution of infiltration in the lung tissue, which was accompanied by the normalization of the parameters of the antioxidant protection system, was revealed under the influence of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide. Conclusions: the use of methyldioxotetrahydropyrimidine sulfonisonicotinoyl hydrazide as a pathogenetic medication for patients, who received antituberculosis treatment, results in substantial positive clinic-laboratory dynamics, increase of treatment efficiency, and normalization of free-radical oxidation indices in comparison with those, who received standard pathogenetic therapy.
About the Authors
L. A. Shovkun
Rostov State Medical University, Rostov-on-Don
Russian Federation
Russian Federation
Head of the Tuberculosis Department
prof., Dr. Sc., principal phthisiologist of SFR
Cell phone 8928188608
E. D. Kampos
Rostov State Medical University, Rostov-on-Don
Russian Federation
Russian Federation
Assistant professor, Tuberculosis Department
Cell phone 89064292036
A. V. Konstantinova
Rostov State Medical University, Rostov-on-Don
Russian Federation
Russian Federation
Assistant professor, Tuberculosis Department
Cell phone 89185342820
I. M. Franchuk
Rostov State Medical University, Rostov-on-Don
Russian Federation
Russian Federation
PhD student, Tuberculosis Department
Cell phone 89086909197
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Review
For citations:
Shovkun L.A., Kampos E.D., Konstantinova A.V., Franchuk I.M. Free-radical oxidation condition of the patients with infiltrative pulmonary tuberculosis depending on the pathogenetic treatment method. Medical Herald of the South of Russia. 2017;8(2):46-53. (In Russ.) https://doi.org/10.21886/2219-8075-2017-8-2-46-53
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