БУРАЯ ЖИРОВАЯ ТКАНЬ У ВЗРОСЛЫХ: СОГЛАСИТЕЛЬНОЕ МНЕНИЕ И РЕКОМЕНДАЦИИ ДЛЯ ПРОВЕДЕНИЯ БУДУЩИХ ЭСКПЕРИМЕНТОВ
https://doi.org/10.21886/2219-8075-2016-3-4-13
Аннотация
C 25 по 26 февраля 2014г в Национальном Институте Здоровья, США, состоялся международный семинар «Изучение роли бурой жировой ткани у людей», цель которого была подытожить современные знания и представления о физиологии бурой жировой ткани (БуЖТ) у взрослых и использовании ее термогенной активности для лечения ожирения. В ходе докладов и дискуссий ведущие ученые сошлись на том, что физиологическая роль БуЖТ крайне сложная и не ограничивается термогенезом и регуляцией веса. В связи с этим необходимы дальнейшие исследования, которые будут изучать роль БуЖТ в фундаментальных физиологических процессах, таких как гомеостаз глюкозы, кахексия, физическая активность, структура кости, сон, циркадные ритмы и др. Согласительное мнение экспертов и рекомендации для проведения будущих экспериментов были резюмированы в статье Aaron M. Cypess, Carol R. HaftMaren, R. Laughlin and Houchun H. Hu. Brown Fat in Humans: Consensus Points and Experimental Guidelines // Cell Metabolism. 2014 Sep 2;20(3):408-15. DOI: 10.1016/j.cmet.2014.07.025, расширенный реферат которой представлен авторами настоящей публикации.
Об авторах
Н. И. Волкова
Ростовский государственный медицинский университет
Россия
Россия
Заведующая кафедрой внутренних болезней №3, доктор медицинских наук, профессор РостГМУ.
344022, г. Ростов-на-Дону, пер. Нахичеванский, 29. E-mail: dim3.rostgmu@gmail.com
М. И. Поркшеян
Ростовский государственный медицинский университет
Россия
Россия
Доцент кафедры внутренних болезней №3, кандидат медицинских наук РостГМУ.
344022, г. Ростов-на-Дону, пер. Нахичеванский, 29. E-mail: dim3.rostgmu@gmail.com
А. Н. Гюльмагомедова
Ростовский государственный медицинский университет
Аспирант кафедры внутренних болезней №3 РостГМУ.
344022, г. Ростов-на-Дону, пер. Нахичеванский, 29. E-mail: dim3.rostgmu@gmail.com
Список литературы
1. Harms M. Brown and beige fat: development, function and therapeutic potential. /M.Harms, P.Seale// Nat Med.2013.Vol.19.P.1252-1263.
2. Nedergaard J. Unexpected evidence for active brown adipose tissue in adult humans /J. Nedergaard, T.Bengtsson, B.Cannon // Am. J. Physiol. Endocrinol. Metab. – 2007. – Vol. 293. – P. 444- 452.
3. Bachman E. S. BetaAR signaling required for diet-induced thermogenesis and obesity resistance / E. S. Bachman, H. Dhillon, C. Y. Zhang [et al.] // Science. – 2002. – Vol. 297. – P. 843-845.
4. Lee P. Inducible brown adipogenesis of supraclavicular fat in adult humans. /P.Lee, M.M Swarbrick, J.T. Zhao [et al.] // Endocrinology. -2011.-Vol.152.-P.3597–3602.
5. Wu J. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human / J. Wu, P. Bostrom, L.M Sparks [et al.] // J. Cell.2012.Vol.150.-P 366 –376.
6. Sharp L.Z., Human BAT possesses molecular signatures that resemble beige/brite cells. /L.Z Sharp, K.Shinoda, [et al.] // S.PLoS ONE.2012.-Vol.7.-P.452.
7. Cypess A.M. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. / A.M.Cypess, A.P.White, C.Vernochet [et al.] // Nat. Med.- 2012.-Vol.19.-P.635–639.
8. Jespersen N.Z. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. / N.Z.Jespersen, T.J. Larsen, L.Peijs [et al.] // Cell Metab. 2013.-Vol. 17.-P.798–805.
9. Cohen P. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. /P.Cohen, J.D.Levy, Y.Zhang [et al.] // Cell .-2014.-Vol.156.P.304–316.
10. Huttunen P. The occurrence of brown adipose tissue in outdoor workers. /P.Huttunen, J.Hirvonen, and V.Kinnula.// Eur. J. Appl. Physiol. Occup. Physiol.-1981.Vol.46.P.339–345.
11. Blondin D.P. Increased brown adipose tissue oxidative capacity in cold-acclimated humans./ D.P.Blondin, S.M. Labbe, J.Tingelstad [et al.] // J. Clin. Endocrinol. Metab.-2014.Vol.99.P.438–446.
12. Lee P. Functional thermogenic beige adipogenesis is inducible in human neck fat. / P.Lee, C.D.Werner, E.Kebebew// J. Obes. (Lond.).2014a.-Vol.38.-P.170–176.
13. Lee P. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. / P.Lee, J.D.Linderman, S.Smith [et al.]// Cell Metab. -2014.-Vol.19.-P. 302–309.
14. Van der Lans A.A. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. /A.A.van der Lans, J.Hoeks, B.Brans [et al.]// J. Clin. Invest.2013.-P.123;
15. Young P. Brown adipose tissue in the parametrial fat pad of the mouse. / P.Young, J.R.Arch, and M.Ashwell.// FEBS Lett.-1984.Vol.167.-P.10–14.
16. Skarulis M.C. Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. / M.C.Skarulis, F.S.Celi, E.Mueller [at al.]//
17. J. Clin. Endocrinol. Metab.2010.-Vol. 95.-P. 256–262.
18. Orava J. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. /J.Orava, P.Nuutila, M.E.Lidell [et al.] // Cell Metab. -2011.-Vol.14.-P. 272–279.
19. Bauwens M. Molecular imaging of brown adipose tissue in health and disease. /M.Bauwens, R.Wierts, B.van Royen [et al.] Eur. J. Nucl. Med. Mol. Imaging. -2014.-Vol.41.P.776–791.
20. Hu H.H. Quantitative proton MR techniques for measuring fat. /H.H.Hu and H.E.Kan, //NMR Biomed. -2013.Vol.26.P.1609– 1629.
21. Hamilton G. MR properties of brown and white adipose tissues. / G.Hamilton, D.L.Smith, M.Bydder [et al.]// J. Magn. Reson. Imaging. -2011.-Vol.34.P.468–473.
22. Chen Y.C. Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging./Y.C. Chen, A.M.Cypess, Y.C. Chen, [et al.]// J. Nucl. Med. -2013.Vol.54.P.1584–1587.
23. Baba S. CT Hounsfield units of brown adipose tissue increase with activation: preclinical and clinical studies./ S. Baba, H.A Jacene, J.M.Engles [et al.]// J. Nucl. Med.-2010.Vol.51.-P.246–250.
24. Khanna A. Detecting brown adipose tissue activity with BOLD MRI in mice. /A.Khanna and R.T. Branca.// Magn. Reson. Med.- 2012.Vol.68.-P.1285–1290.
25. Clerte M. Brown adipose tissue blood flow and mass in obesity: a contrast ultrasound study in mice. / M.Clerte, D.M Baron, P.Brouckaert [et al.]// J. Am. Soc. Echocardiogr.-2013.-Vol.26.P.1465–1473.
26. Lin S.F. Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C] MRB for brown adipose tissue imaging. / S.F Lin, X.Fan, C.W.Yeckel [et al.]// Nucl. Med. Biol.-2012.Vol.39.-P.1081–1086.
27. Madar I. 18F-fluorobenzyl triphenyl phosphonium: a noninvasive sensor of brown adipose tissue thermogenesis. /I.Madar, T.Isoda, P.Finley [et al.]// J. Nucl. Med.-2011.-Vol.52.-P.808–814.
28. Arunachalam K. Characterization of a digital microwave radiometry system for noninvasive thermometry using a temperature-controlled homogeneous test load. /K.Arunachalam, P.R.Stauffer, P.F Maccarini [et al.]// Phys. Med. Biol.-2008.Vol.53.-P.3883–3901.
29. Rodrigues D.B. Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism. /D.B.Rodrigues, P.F.Maccarini, S.Salahi [et al.]// Proc. SPIE.2013.P.8584.
30. Chen K.Y. Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature./ K.Y.Chen, R.J.Brychta, J.D.Linderman [et al.]// J. Clin. Endocrinol. Metab.-2013.-Vol.98.-P.1218–1223.
31. van der Lans A.A. Cold-activated brown adipose tissue in human adults—methodological issues. Am. / A.A. van der Lans, R.Wierts, , M.J. Vosselman [et al.]// J. Physiol. Regul. Integr. Comp. Physiol. 2014.-Vol.307 (2); R103-13.
32. Broeders E. Endogenous ways to stimulate brown adipose tissue in humans. / E.Broeders, N.D.Bouvy and W.D. van Marken Lichtenbelt.//Ann. Med. Published online February 2014.-Vol.13.-P.1014.
33. Azhdarinia A. A peptide probe for targeted brown adipose tissue imaging. / A.Azhdarinia, A.C.Daquinag, C.Tseng [et al.]// Nat. Commun.-2013.-Vol.4.P.2472.
34. Muzik O.15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat./ O.Muzik, T.J.Mangner, W.R.Leonard [et al.]// J. Nucl. Med.-2013.-Vol.54.P.523–531.
35. Yoneshiro T. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. / T.Yoneshiro, S.Aita, M.Matsushita [et al.]// Obesity (Silver Spring).-2011.-Vol.19.P.13–16.
36. Orava J. Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans. / J.Orava, P.Nuutila, T.Noponen [et al.]// Obesity (Silver Spring).-2013.Vol.21.-P.2279–2287.
37. Kajimura S. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. /Kajimura S. and М.Saito.// Annu. Rev. Physiol.-2014.Vol.76.-P.225–249.
38. Bonet M.L. Pharmacological and nutritional agents promoting browning of white adipose tissue./ M.L. Bonet, P.Oliver, and A. Palou// Biochim. Biophys. Acta 2013.-Vol.1831.-P.969–985.
39. Cannon B. Thermogenesis challenges the adipostat hypothesis for body-weight control. /B.Cannonand J. Nedergaard. // Proc. Nutr. Soc.-2009.-Vol.68.-P.401–407.
40. Peirce V. Regulation of glucose homoeostasis by brown adipose tissue. /V. Peirce and A.Vidal-Puig // Lancet Diabetes Endocrinol.- 2013.-Vol.1.-P.353–360.
41. Bredella M.A. Positive effects of brown adipose tissue on femoral bone structure. / M.A.,Bredella, C.M. Gill, C.J.Rosen [et al.]// Bone.-2014.-Vol.58.-P.55–58.
42. Ponrartana S. On the relevance of brown adipose tissue in children. / S. Ponrartana, H.H.Hu and V.Gilsanz//Ann. N Y Acad. Sci.-2013.-Vol.1302.-P.24–29.
43. Hindle A.G. Intrinsic circannual regulation of brown adipose tissue form and function in tune with hibernation./ A.G Hindle and S.L Martin.// Am. J. Physiol. Endocrinol. Metab. 2014.-Vol.306.-P.284–299.
44. Szentirmai E. Intact brown adipose tissue thermogenesis is required for restorative sleep responses after sleep loss. / E.Szentirmai and S. L Kapa //Eur. J. Neurosci.-2014.-Vol.39.P.984–998.
45. Villarroya J. An endocrine role for brown adipose tissue? / J.Villarroya, R. Cereijo and F.Villarroya // Am. J. Physiol. Endocrinol. Metab.-2013.-Vol.305.P.567–572.
46. Virtanen K.A. Functional brown adipose tissue in healthy adults. /K.A.Virtanen, M.E.Lidell, J.Orava [et al.] //N. Engl. J. Med.- 2009.-Vol.360.-P.1518–1525.
47. Mirbolooki M.R. Adrenergic pathway activation enhances brown adipose tissue metabolism: a [18F]FDG PET/CT study in mice. /M.R. Mirbolooki, S.K. Upadhyay, C.C.Constantinescu [et al.]// Nucl. Med. Biol.-2014.-Vol.41.-P.10–16.
48. Ouellet V. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. / V.Ouellet, S.M. Labbe, D.P.Blondin et al. // J. Clin. Invest.-2012.Vol.122.-P.545–552.
49. Hu H.H. Differential computed tomographic attenuation of metabolically active and inactive adipose tissues: preliminary findings./H.H. Hu, S.A.Chung, K.S. Nayak [et al.] // J. Comput. Assist. Tomogr.-2011.-Vol.35.-P.65–71.
50. Branca R.T. Detection of brown fat mass and activity by hyperpolarized xenon MR. Proceedings of the 21st Annual Meeting ISMRM, Salt Lake City, /R.T.Branca, C.White and L.Zhang // UT, № 404.-2013.
51. Branca R.T. In vivo noninvasive detection of brown adipose tissue through intermolecular zero-quantum MRI. / R.T. Branca, L.Zhang, W.S.Warren [et al.] // PLoS ON.-2013.-Vol.8.P.74206.
52. Branca R.T. Detection of brown fat thermogenesis by hyperpolarized Xenon gas MR. / R.T.Branca, L.Zhang, C. White [et al.]// Proceedings of the 21st Annual Meeting ISMRM, Salt Lake City, Utah, USA.-№814.-2013.
53. Lau A.Z. Noninvasive identification and assessment of functional brown adipose tissue in rodents using hyperpolarized 13C imaging. /A.Z.Lau, A.P.Chen, Y.Gu [et al.] // Int. J. Obes. (Lond.).-2014.-Vol.38.-P.126–131.
54. Van Rooijen, B.D., van der Lans, A.A., Brans, B., Wildberger, J.E., Mottaghy, F.M., Schrauwen, P., Backes, W.H., and van Marken Lichtenbelt, W.D. Imaging cold-activated brown adipose tissue using dynamic T2*weighted magnetic resonance imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography. / B.D. van Rooijen, A.A. van der Lans, B.Brans [et al.] // Invest. Radiol.-2013.-Vol.48.-P.708–714.
55. Symonds, M.E., Henderson, K., Elvidge, L., Bosman, C., Sharkey, D., Perkins, A.C., and Budge, H. Thermal imaging to assess agerelated changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children. /M.E. Symonds, K.Henderson, L.Elvidge [et al.] // J. Pediatr.- 2012.-Vol.161.-P.892–898.
Рецензия
Для цитирования:
Волкова Н.И., Поркшеян М.И., Гюльмагомедова А.Н. БУРАЯ ЖИРОВАЯ ТКАНЬ У ВЗРОСЛЫХ: СОГЛАСИТЕЛЬНОЕ МНЕНИЕ И РЕКОМЕНДАЦИИ ДЛЯ ПРОВЕДЕНИЯ БУДУЩИХ ЭСКПЕРИМЕНТОВ. Медицинский вестник Юга России. 2016;(3):4-13. https://doi.org/10.21886/2219-8075-2016-3-4-13
For citation:
Volkova N.I., Porksheyan M.I., Gyulmagomedova A.N. BROWN ADIPOSE TISSUE IN ADULTS: CONSENSUS POINTS AND GUIDELINES FOR FUTURE EXPERIMENTS. Medical Herald of the South of Russia. 2016;(3):4-13. (In Russ.) https://doi.org/10.21886/2219-8075-2016-3-4-13
Просмотров:
723
Послать статью по эл. почте 