ACUTE PANCREATITIS, DIAGNOSTICS AND PROGNOSIS
https://doi.org/10.21886/2219-8075-2014-4-42-44
Abstract
Purpose: to study the levels of lactoferrin (LF) and macroglobulin (MG) in the serum of patients with acute pancreatitis depending on the severity of inflammation and prediction of disease outcome.
Materials and methods: 93 patients were observed with various forms of acute pancreatitis in the serum of them in the dynamics by radial immunodiffusion method there were investigated the concentration of MG and ELISA - the level of LF.
Results: there was an increase in the level of WBF patients depending on various forms of acute pancreatitis and severity of inflammation and clear tendency to decrease with increasing level of MG severity in pancreatitis DIF sequence, SP, IP.
Summary: In patients with acute pancreatitis there was a high concentration and low level of LF - MG which may indicate serious destructive processes in the pancreas. Following the treatment the level of LF decreases and MG - rises to normal which is an important diagnostic criterion for assessing the severity of the inflammatory process and the effectiveness of treatment for this disease. Considering these, indexes of LF and MG can be included into the standard of diagnostics and monitoring of treatment in various forms of acute pancreatitis.
Materials and methods: 93 patients were observed with various forms of acute pancreatitis in the serum of them in the dynamics by radial immunodiffusion method there were investigated the concentration of MG and ELISA - the level of LF.
Results: there was an increase in the level of WBF patients depending on various forms of acute pancreatitis and severity of inflammation and clear tendency to decrease with increasing level of MG severity in pancreatitis DIF sequence, SP, IP.
Summary: In patients with acute pancreatitis there was a high concentration and low level of LF - MG which may indicate serious destructive processes in the pancreas. Following the treatment the level of LF decreases and MG - rises to normal which is an important diagnostic criterion for assessing the severity of the inflammatory process and the effectiveness of treatment for this disease. Considering these, indexes of LF and MG can be included into the standard of diagnostics and monitoring of treatment in various forms of acute pancreatitis.
About the Authors
V. A. Zurnadzhjants
Astrakhan State Medical University
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
E. A. Kchibekov
Astrakhan State Medical University
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
M. A. Serdyukov
Astrakhan State Medical University
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
V. A. Bondarev
Astrakhan State Medical University
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
D. S. Dibrova
Astrakhan State Medical University
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
Russian Federation
Department of Surgical Diseases, Faculty of Pediatrics
References
1. Абрамченко В.В., Гусева Е.Н. - Медикаментозныйаборт. - Варзин, С.А. Прогностическая ценность лабораторных показателей при панкреонекрозе / С.А.Варзин, А.Н.Шишкин, В.В.Ивлев // Вестник хирургической гастроэнтерологии. Приложение к журналу. - 2014. - С.65-66.
2. Гербенко, Г.И. Оптимизация диагностических методов у больных острым панкреатитом / Г.И. Гербенко, Р.М. Сманило, А.В. Кузнецов // Медицина неотложных состояний.- 2007. - №1(8). – С.117.
3. Lee, V.T. Chung A.Y., Chow P.K. et al. Infected pancreatic necrosis - an evaluation of the timing and technique necrosectomy in a Southeast Asian population/ V.T. Lee, A.Y. Chung, P.K. Chow et al // Ann. Acad. Med. Singapore., 2006.-35(8).-Р. 523–530.
4. Клиническая хирургия: национальное руководство: в 3 т. /под ред. В.С.Савельева, А.И.Кириенко.- М.: Геотар-Медиа. - 2009. - Т.2. - С.196-229.
5. Шапошников, В.И. Некоторые нерешенные вопросы хирургической панкреатологии // Вестник хирургической гастроэнтерологии. Приложение к журналу. - 2014. - С.80-81.
6. Buechler, M.W., Gloor B., Muller C.A. et al. Acute necrotizing pancreatitis: treatment strategy according to the status of infection/ M.W. Buechler, B. Gloor, C.A. Muller et al // Ann. Surg., 2000.- 232(5).- P. 619–626.
7. APACHE II. A severity of disease classification system / W.A. Knaus, E.A. Draper, D.P.Wagner, J.E. Zimmerman // Crit Care Med., 1985. - Vol. 13. -P. 818-829
8. Назаров, П. Г. // Реактанты острой фазы воспаления. СПб.: «Наука». – 2001.- 401с.
9. Brown A., Baillargeon J.D., Hughes M.D., Banks P.A. Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis/
10. A. Brown, J.D. Baillargeon, M.D. Hughes, Banks P.A. // Pancreatology.- 2002. - 2(2). - P.104–107.
11. Рамазанов, М.В., Кчибеков Э.А., Никулина Д.М. Ферропротеины при вентральной патологии / М.В Рамазанов, Э.А. Кчибеков, Д.М. Никулина // Астраханский медицинский журнал. - 2011.- №2. Т. 6. – С.232-233.
Review
For citations:
Zurnadzhjants V.A., Kchibekov E.A., Serdyukov M.A., Bondarev V.A., Dibrova D.S. ACUTE PANCREATITIS, DIAGNOSTICS AND PROGNOSIS. Medical Herald of the South of Russia. 2014;(4):42-44. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-42-44
Views:
492
Email this article 