THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS
https://doi.org/10.21886/2219-8075-2015-4-55-60
Abstract
Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.
Materials and methods: 160 railroad engineers (RRE) were examined. They had work experience from 1 to 35 years. As controls, 100 healthy volunteers wereexamined. The level of adrenocorticotropic hormone, cortisol and corticosterone in the blood as a condition of the stress system (SS) were measured.
Results: it was found out that the effect of stress reaction is accompanied by the serial reaction of the SS: activation period, adaptation and disadaptation. In the activation and the adaptation periods was marked increase synthesis of NO against the background moderate increase of ET-1 concentration. The disadaptation period was accompanied by decrease in NO production and doubling the level of ET-1, an increase of the thickness of the carotid intima-media complex (as evidence of vascular remodeling processes). Insufficient synthesis of the vasodilators, excessive production of the vasoconstrictors, remodeling of the vascular wall contributed to the formation, process and progression of the hypertension.
Conclusion: these results specify the pathogenic mechanisms of AH in condition of CS.
About the Authors
I. S. Lutskyy
Donetsk National Medical University of Maxim Gorky
Russian Federation
Russian Federation
S. V. Ziablices
Donetsk National Medical University of Maxim Gorky
Russian Federation
Russian Federation
M. S. Kishenia
Donetsk National Medical University of Maxim Gorky
Russian Federation
Russian Federation
L. V. Liutykova
Donetsk National Medical University of Maxim Gorky
Russian Federation
Russian Federation
P. A. Chernobrivec
Donetsk National Medical University of Maxim Gorky
Russian Federation
Russian Federation
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Review
For citations:
Lutskyy I.S., Ziablices S.V., Kishenia M.S., Liutykova L.V., Chernobrivec P.A. THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS. Medical Herald of the South of Russia. 2015;(4):55-60. https://doi.org/10.21886/2219-8075-2015-4-55-60
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