C(-159)T GENETIC POLYMORPHISM OF CD14 MONOCYTES RECEPTORS AT GRAVE’S DISEASE PATIENTS WITH VARIOUS TYPE OF THE ANTIBODIES ENDOTOXIN RESPONSE
https://doi.org/10.21886/2219-8075-2015-4-21-25
Abstract
Purpose: studying of C(-159)T polymorphism of CD14 receptor gene at 87 GD patients with various type of the antibodiesendotoxin (ET) response.
Materials and methods: the antiendotoxin Ig G (anti-ET-IgG) blood concentrations were studied by ELISA for subdivided
group patients according antibodies response to ET. Genetic polymorphism defined by PCR. All patients with GD were divided into two groups. In the 1st group – 21 GD patients, which level of anti-ET-IgG was less than M±
About the Authors
V. A. BeloglazovRussian Federation
Department of internal medicine №2
U. U. Kulagina
Russian Federation
Department of internal medicine №2
References
1. Chen ML. Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and Graves’ disease risk: a metaanalysis of 11 case-control studies /Chen ML, Liao N, Zhao H // PLoS One. 2014.Jan 21. 9(1).
2. Doğru-Abbasoğlu S Arg25Pro (c.915G>C) polymorphism of transforming growth factor β1 gene increases the risk of developing Graves’ disease / Doğru-Abbasoğlu S, Vural P, Baki M. // Int Immunopharmacol. 2014. Apr 14. p: S1567- 5769(14)00124-6.
3. Ni J CTLA-4 CT60 (rs3087243) polymorphism and autoimmune thyroid diseases susceptibility: a comprehensive meta-analysis / Ni J, Qiu LJ, Zhang M, Wen PF. // Endocr Res. 2014. Apr 3.
4. Tsai KH. Association of Interleukin-16 Polymorphisms with Graves’ Disease in a Taiwanese Population /Tsai KH, Chang CY, Tsai FJ, Lin HJ. // Chin J Physiol. 2014. Apr 30;57(2).
5. Chen ML. Lack of Association between the IL-13 C-1112T, G2044A Polymorphisms and Graves’ Disease Risk: Evidence from a Meta-analysis /Chen ML, Liao N, Zhao H, Huang J. // Immunol Invest. 2014;43(4):337-48. 6. Liu X.Q. The association between C-159T polymorphism in promoter region of CD l4 polymorphism and coronary heart disease / Liu X.Q., Yang J.Y. // Yi Xue Xin Zhi Za Zhi 20.-2010.- Р.427–429.
6. Кулагина Ю.Ю. Генетический полиморфизм CD14 рецепторов у больных диффузным токсическим зобом / Кулагина Ю.Ю., Малый К.Д. // Імунологія та алергологія. – 2011. - №4. – С. 23-26.
7. Пат. 70193 А Україна, МКІ 7 А61К31/01. Спосіб визначення антитіл до ліполісахаридів грам-негативних бактерій: Пат. 70193 А Україна, МКІ 7 А61К31/01 А. И. Гордиенко, В. А. Белоглазов; КГМУ им. С. И. Георгиевского; Завл. 29.12.03; Опубл. 15.09.04, Бюл.№9.
8. Белоглазов В.А. Антиэндотоксиновый иммунитет и уровень С-реактивного белка у больных диффузным токсическим зобом с патологией сердца / Белоглазов В.А., Кулагина Ю.Ю.// Международный эндокринологический журнал.- №2 (58), -2014.- с. 15-20.
Review
For citations:
Beloglazov V.A., Kulagina U.U. C(-159)T GENETIC POLYMORPHISM OF CD14 MONOCYTES RECEPTORS AT GRAVE’S DISEASE PATIENTS WITH VARIOUS TYPE OF THE ANTIBODIES ENDOTOXIN RESPONSE. Medical Herald of the South of Russia. 2015;(4):21-25. (In Russ.) https://doi.org/10.21886/2219-8075-2015-4-21-25