VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS
https://doi.org/10.21886/2219-8075-2015-4-18-21
Abstract
Purpose: studying of endotoxin antibodies level of classes G, M, A and level of C-reactive protein at patients on a programhemodialysis and a constant peritoneal dialysis.
Materials and methods:16 patients with a chronic kidneys disease 5 stage on a peritoneal dialysis and 62 patients on a program hemodialysis are surveyed. Level endotoxin antibody classes G, M, A, and C-reactive protein was determined by ELISA.
Results: it is established that patients on a peritonial dialysis have level anti-ET-IgG in 4.9 times in comparison with group of conditionally healthy patients, and levels anti-ET-IgA and anti-ET-IgM didn’t differ from norm indicators. Also increase of level of C-reactive protein in 8.8 times, in comparison with indicators of healthy donors. At patients on a program hemodialysis increase in 5.6 times anti-ET-IgG, and in 8 times of C-reactive protein in comparison with group of healthy patients. And levels anti-ET-IgA and anti-ET-IgM also didn’t differ from norm indicators. Levels of endotoxin antibodies and C-reactive protein at patients on a hemodialysis and on a peritonial dialysis among didn’t differ.
Conclusion: in both groups of patients found an increased antibody response to ET (on a high level of anti-ET-IgG) against the background of a high level of systemic inflammation (at the level of C-reactive protein). There is chronic endotoxin aggression in hemodialysis patients.
About the Authors
V. A. Biloglazov
FSAEE AE «Crimean Federal University named after V.I. Vernadsky», Medical Academy named after S.I. Georgievsky
Russian Federation
Department of Internal Medicine № 2
Russian Federation
Department of Internal Medicine № 2
A. V. Klimchuk
FSAEE AE «Crimean Federal University named after V.I. Vernadsky», Medical Academy named after S.I. Georgievsky
Russian Federation
Department of Internal Medicine № 2
Russian Federation
Department of Internal Medicine № 2
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Review
For citations:
Biloglazov V.A., Klimchuk A.V. VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS. Medical Herald of the South of Russia. 2015;(4):18-21. (In Russ.) https://doi.org/10.21886/2219-8075-2015-4-18-21
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