INJECTING DRUG USE AS A FACTOR CONTRIBUTES TO HIV-INFECTION
https://doi.org/10.21886/2219-8075-2015-1-86-90
Abstract
Purpose: to determine the nature of the impact of injecting drug use on cellular immunity and assessment of the importance of drug use as a factor contributing to HIV infection and aff ect the course of disease in HIV- positive patients.
Materials and methods: surveyed 144 people - 109 patients with drug addiction, HIV infection and HIV - positive injecting drug users and 35 healthy individuals.
Results: found that injecting drug potentiates caused by HIV infection decrease the percentage of helper cells ( CD4 + lymphocytes ), natural killer T (CD3 +16 +56 + lymphocytes), natural killer cells (CD3- 16 +56 + cells ), increased cytotoxic T lymphocytes (CD8 + lymphocytes), the proportion and absolute number of T- lymphocyte activation characteristics (CD3 + HLA-DR + cells).
Summary: injecting drug use increases the risk of infection among injecting drug users (IDUs) without HIV, and decreases the antiviral response in HIV- positive patients, a statistically signifi cant potentiating caused by HIV in the blood decrease in helper cells, and natural killer T- natural, regulatory cells, immune hyperactivation that contributes to the progression of the disease.
About the Authors
Е. P. Stanko
Grodno State Medical University
Belarus
Belarus
S. A. Lyalikov
Grodno State Medical University
Belarus
Belarus
S. A. Igumnov
Belarusian State Medical University; State Institute of Management and Social Technologies, Belarusian State University
Belarus
Belarus
V. M. Cyrkunov
Grodno State Medical University
Belarus
Belarus
N. V. Matievskya
Grodno State Medical University
Belarus
Belarus
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Review
For citations:
Stanko Е.P., Lyalikov S.A., Igumnov S.A., Cyrkunov V.M., Matievskya N.V. INJECTING DRUG USE AS A FACTOR CONTRIBUTES TO HIV-INFECTION. Medical Herald of the South of Russia. 2015;(1):86-90. (In Russ.) https://doi.org/10.21886/2219-8075-2015-1-86-90
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