INTERACTION OF PERSPECTIVE ANTIDEPRESSANT WITH NOOTROPIC PROPERTIES 2-METHYL-3-PHENYLAMINOMETHYLQUINOLIN-4-ONE WITH CNS STIMULANTS AND DEPRESSANTS

Abstract

Purpose. To research possible interactions of 2-methyl-3-phenylaminomethylquinolin-4-one (3-AMQ) with CNS stimulants and depressants.Materials and methods. The interaction of the said substance with strychnine and thiosemicarbazide was studied on the seizure models, with caffeine - in the open field test, with CNS depressants (sodium thiopental, ethanol) - measuring duration of the anesthetic sleep.Results. The trend of attenuation of strychnine and thiosemicarbazide convulsive action was revealed on seizure models for 3-AMQ. In the open field test 3-AMQ leveled the anxiogenic effects of caffeine that was reflected in the exploratory activity increase. The trend of elongation of narcosis induction time (up to 18%) and reduction of narcosis duration (up to 17%) was found in the model using thiopental-induced anesthesia. In the ethanol-induced narcosis 3-AMQ reduced the duration of animals’ anesthetic sleep by 19.2% (p<0.05).Summary. The absence of pro-convulsive properties and potentiating interactions with barbiturates was proved for 3-AMQ. Beneficial modulating influence on effects of caffeine was revealed. The alcoprotective activity of 3-AMQ was proved.