RESEARCH OF INFLUENCE OF POLYMORPHISM Μ-OPIOID RECEPTOR GENE ON THE TOTAL INTRAVENOUS ANAESTHESIA
https://doi.org/10.21886/2219-8075-2014-1-65-70
Abstract
Purpose: To study the influence of polymorphism µ-opioid receptor for the total intravenous anesthesia.Materials and methods: The study included 100 patients, which were performed by various gynecological operations withthe entry into the abdominal cavity. Intraoperative in all patients evaluated the change bispectral index, blood pressure, oxygensaturation. Analyzed the frequency of the polymorphism of gene mu-opioid receptor OPRM1 (A118G).Results: We found that the carriers of polymorphic genotype of the study of the gene was observed increased consumptionof narcotic analgesics during the operation, later performed extubation, often recorded postoperative complications (nausea andvomiting) and there was a higher score on the visual-analogue scale in the early postoperative period.Summary: The carriers of polymorphic genotype of µ-opioid receptor А118G, as heterozygous and homozygous are need ofhigher doses of narcotic analgesics during surgery and the more careful observation in the early postoperative period because ofthe possible complications.
About the Authors
O. A. Maharin
Rostov State Medical University
Russian Federation
Department of Pharmacology and Clinical Pharmacology
Russian Federation
Department of Pharmacology and Clinical Pharmacology
Y. S. Maklyakov
Rostov State Medical University
Russian Federation
Department of Pharmacology and Clinical Pharmacology
Russian Federation
Department of Pharmacology and Clinical Pharmacology
V. M. Genilo
Rostov State Medical University
Russian Federation
Department of Pharmacology and Clinical Pharmacology
Russian Federation
Department of Pharmacology and Clinical Pharmacology
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Review
For citations:
Maharin O.A., Maklyakov Y.S., Genilo V.M. RESEARCH OF INFLUENCE OF POLYMORPHISM Μ-OPIOID RECEPTOR GENE ON THE TOTAL INTRAVENOUS ANAESTHESIA. Medical Herald of the South of Russia. 2014;(1):65-70. (In Russ.) https://doi.org/10.21886/2219-8075-2014-1-65-70
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