Cytokine profile of patients with coronary artery disease undergoing coronary artery stenting: the influence of psychoemotional status

Objective: to investigate the influence of percutaneous coronary intervention (PCI) on cytokine levels in patients with stable IHD, to analyze the features of cytokine status before and after PCI, depending on the development of adverse outcomes within a year after the intervention, and to assess the influence of emotional state changes at cytokine level. Materials and methods: 58 patients with stable IHD hospitalized for PCI were included into the study. The levels of IFN-γ, IL-17, IL-6, IL-4, TNF-α were measured initially and on the third day after the intervention. Psychometric testing was carried out using the CES-D and HADS questionnaires. Results: according to psychometric testing results, 20.7% of patients had emotional state changes. Groups of patients were comparable by clinical features. The presence of emotional disturbances was complemented by an increase in the level of IL-6. PCI was accompanied by an increase in proinflammatory potential, which was reflected in an increase in IL-17 and TNF-α levels in the absence of IL-4 level dynamics. The presence of depression’s indicators (by using CES-D scale) was associated with a significant increase in IL-6 and IFN-γ levels on the third day after PCI. A higher level of IL- 17 both before and after stenting and IL-6 after stenting was associated with the development of adverse outcomes.

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