Causes of deaths in HIV-infected patients not associated with immunodeficiency progression
https://doi.org/10.21886/2219-8075-2026-17-2-79-87
Abstract
Objective: analysis of the causes of deaths in HIV-infected patients with the identification of the most significant nosology for making a prognosis and determining the direction of preventive measures.
Materials and methods: the data on deaths in HIV-infected patients for the period from 2019 to 2024 living in the Omsk Region were analyzed. The study is retrospective, continuous, descriptive. The long-term dynamics were assessed and forecasting was performed using a regression model.
Results: during the analyzed period, a tendency towards an increase in fatal outcomes of patients with HIV infection was noted. By gender, no significant changes in the ratio of men and women were revealed. However, significant changes in the age structure of the deceased were noted towards a shift to older age groups. The proportion of fatal outcomes from the progression of HIV infection and AIDS is decreasing, with a simultaneous increase in causes not related to the underlying disease. An increase in fatal outcomes from diseases of the cardiovascular system, gastrointestinal tract, injuries, poisoning and external causes was observed. However, when calculating the growth rate, a significant increase was noted in diseases of the respiratory system and cardiovascular pathology as causes of fatal outcomes in patients with HIV infection.
Conclusions: during the analyzed period, the age and structure of causes of fatal outcomes among patients with HIV infection changed significantly. The data obtained will allow us to develop and make informed decisions on the prevention of somatic pathology in the aging population with HIV infection.
About the Authors
L. V. Puzireva
Omsk State Medical University
Russian Federation
Competing Interests:
Russian Federation
Larisa V. Puzireva, Dr. Sci. (Med.), head of the Department of Pediatric Infectious Diseases
Omsk
Competing Interests:
Authors declares no conflict of interest.
M. V. Balabokhina
Center for the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Competing Interests:
Russian Federation
Maria V. Balabokhina, infectious disease specialist, Deputy Chief Physician for Preventive and Organizational-Methodological Work
Omsk
Competing Interests:
Authors declares no conflict of interest.
O. V. Antonov
Omsk State Medical University
Russian Federation
Competing Interests:
Russian Federation
Oleg V. Antonov, Dr. Sci. (Med.), head of the Department of Pediatrics
Omsk
Competing Interests:
Authors declares no conflict of interest.
References
1. GBD 2021 Causes of Death Collaborators. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990- 2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2100-2132. Erratum in: Lancet. 2024;403(10440):1988. https://doi.org/10.1016/S0140-6736(24)00367-2
2. Vasil’eva A.A., Suvorova M.R., Popova N.M. Characteristics of mortality from diseases associated with HIV infection according to pathological examinations. Modern Science. 2021;(11-2):15-20. (In Russ.). eLIBRARY ID: 47208868 EDN: YOYATO
3. Shahgil’dyan V. I., Sokolova E. V., Yurin O. G., Ladnaya N.N., Kanestri V.G Definition of AIDS cases and causes of death in HIV-infected patients. Epidemiologiya i infekcionnye bolezni. Aktual’nye voprosy. 2020;10(3):70-78. (In Russ.). https://doi.org/10.18565/epidem.2020.10.3.70-8
4. Marty L, Diawara Y, Rachas A, Grabar S, Costagliola D, Supervie V. Projection of age of individuals living with HIV and time since ART initiation in 2030: estimates for France. J Int AIDS Soc. 2022 Sep;25 Suppl 4(Suppl 4):e25986. doi: 10.1002/jia2.25986
5. Leonova O.N., Gribova A.V., Cherkes N.N., Krasnova O.G., Ivanova I.B., Esaulenko E.V. Clinical and epidemiological analysis of fatal outcomes of patients with HIV infection who died in the reporting year of diagnosis. Epidemiologiya I Infektsionnye bolezni (Epidemiology and Infectious Diseases). 2024;29(4):254-261. (In Russ.). https://doi.org/10.51620/3034-1981-2024-29-4-254-261
6. Dessau M.I., Nikolaenko S.L., Lioznov D.A. The effectiveness of treatment depending on an adherence to dispensary observation and antiretroviral therapy in patients with HIV infection. HIV Infection and Immunosuppressive Disorders. 2024;16(1):36-44. (In Russ.) https://doi.org/10.22328/2077-9828-2024-16-1-36-44
7. Trickey A, McGinnis K, Gill MJ, Abgrall S, Berenguer J, et al. Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies. Lancet HIV. 2024;11(3):e176-e185. https://doi.org/10.1016/S2352-3018(23)00272-2
8. Soyiri IN, Reidpath DD. An overview of health forecasting. Environ Health Prev Med. 2013;18(1):1-9. https://doi.org/10.1007/s12199-012-0294-6
9. Ladnaia N.N., Pokrovsky V.V., Kozyrina N.V., Sokolova E.V., Dementyeva L.A. Human immunodeficiency virusrelated mortality in the Russian Federation in 1987–2018. Epidemiologiya, infekcionnye bolezni. Aktual’nye voprosy. 2020;10(3):54–62. (In Russ.). https://doi.org/10.18565/epidem.2020.10.3.54–62
Review
For citations:
Puzireva L.V., Balabokhina M.V., Antonov O.V. Causes of deaths in HIV-infected patients not associated with immunodeficiency progression. Medical Herald of the South of Russia. 2026;17(2):79-87. (In Russ.) https://doi.org/10.21886/2219-8075-2026-17-2-79-87
Views:
92
JATS XML
Email this article 