Clinical features of the peri- and postmenopausal period depending on the morphofunctional asymmetries of women

Objective: to identify clinical features of the course of the peri- and postmenopausal period in women depending on the morphofunctional asymmetries of women. Materials and methods: a total of 205 women in the late stage of the transition to menopause (clinical group I) and 185 women in the postmenopausal period (clinical group II) with clinical manifestations of climacteric syndrome were examined. The severity of climacteric syndrome was assessed using the Green scale, and the lateral behavioral profile of asymmetries was determined using the modified Annette test. Results: in women in the perimenopausal period, regardless of the nature of the lateral phenotype and the severity of climacteric syndrome, vasomotor and psychoemotional disorders were 1.6 times more common than in the postmenopausal period. The highest frequency of clinical manifestations of climacteric syndrome was found in patients with ambidextrous lateral phenotype in both the peri- and postmenopausal periods. Regardless of the severity of climacteric syndrome, vasomotor, somatic and psycho-emotional symptoms statistically significantly prevailed in women with ambidextrous lateral phenotype compared to representatives of the polar right and left phenotypes. Conclusion: the greatest adaptive resource and the lowest frequency and severity of vasomotor, psycho-emotional, somatic and metabolic disorders in climacteric syndrome were found in women with the polar right lateral phenotype, while the most vulnerable constitutional subgroup were women with the ambidextrous phenotype in the peri- and postmenopausal periods.

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