APPLICATION OF COLLAGEN MATRIX – AN INNOVATION IN SURGERY OF POSTRADIATION VESICO-VAGINAL FISTULAS
https://doi.org/10.21886/2219-8075-2014-4-74-78
Abstract
Purpose: to estimate an influence of the collagen biopolymer («collost») to tissues of a living organism in experimental study.
Materials and methods: laboratory rats divided in two comparable experimental groups were underwent to implantation of collost plate thickness of 1.5 mm and 4 mm (the third group was control). Proliferative and secretory activity of fibroblasts were studied at 10 day, 3 and 6 months of postimplantation period by immuno-histochemical method. Process of neovascularization in the area of implantation using a quantitative method of calculating the length of capillaries per unit volume of the granulation tissue, including on a background of artificial immune were studied also.
Results: better proliferative and secretory activity of fibroblasts and angiogenesis activity were revealed in the group of implanted 4 mm-collagen plates.
Summary: the experimental results allow the use of the collagen plate in the surgical treatment of postradiation urogenital fistulas.
Materials and methods: laboratory rats divided in two comparable experimental groups were underwent to implantation of collost plate thickness of 1.5 mm and 4 mm (the third group was control). Proliferative and secretory activity of fibroblasts were studied at 10 day, 3 and 6 months of postimplantation period by immuno-histochemical method. Process of neovascularization in the area of implantation using a quantitative method of calculating the length of capillaries per unit volume of the granulation tissue, including on a background of artificial immune were studied also.
Results: better proliferative and secretory activity of fibroblasts and angiogenesis activity were revealed in the group of implanted 4 mm-collagen plates.
Summary: the experimental results allow the use of the collagen plate in the surgical treatment of postradiation urogenital fistulas.
About the Author
O. B. Loran
Russian Medical Academy of Postgraduate Education
Russian Federation
Department of Urology and Surgical Andrology
Russian Federation
Department of Urology and Surgical Andrology
References
1. Кан Д.В. «Руководство по акушерской и гинекологической урологии», 2-е изд. – M: Медицина, - 1986. - C. 49-67.
2. Лоран О.Б., Дементьева А.В., Твердохлебов Н.Е. «Лечение больных со сложными мочевыми свищами» // Врач, - 2008. - №8. C.45-47.
Review
For citations:
Loran O.B. APPLICATION OF COLLAGEN MATRIX – AN INNOVATION IN SURGERY OF POSTRADIATION VESICO-VAGINAL FISTULAS. Medical Herald of the South of Russia. 2014;(4):74-78. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-74-78
Views:
421
Email this article 