APPLICATION OF COLLAGEN MATRIX – AN INNOVATION IN SURGERY OF POSTRADIATION VESICO-VAGINAL FISTULAS
https://doi.org/10.21886/2219-8075-2014-4-74-78
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Purpose: to estimate an influence of the collagen biopolymer («collost») to tissues of a living organism in experimental study.
Materials and methods: laboratory rats divided in two comparable experimental groups were underwent to implantation of collost plate thickness of 1.5 mm and 4 mm (the third group was control). Proliferative and secretory activity of fibroblasts were studied at 10 day, 3 and 6 months of postimplantation period by immuno-histochemical method. Process of neovascularization in the area of implantation using a quantitative method of calculating the length of capillaries per unit volume of the granulation tissue, including on a background of artificial immune were studied also.
Results: better proliferative and secretory activity of fibroblasts and angiogenesis activity were revealed in the group of implanted 4 mm-collagen plates.
Summary: the experimental results allow the use of the collagen plate in the surgical treatment of postradiation urogenital fistulas.
Materials and methods: laboratory rats divided in two comparable experimental groups were underwent to implantation of collost plate thickness of 1.5 mm and 4 mm (the third group was control). Proliferative and secretory activity of fibroblasts were studied at 10 day, 3 and 6 months of postimplantation period by immuno-histochemical method. Process of neovascularization in the area of implantation using a quantitative method of calculating the length of capillaries per unit volume of the granulation tissue, including on a background of artificial immune were studied also.
Results: better proliferative and secretory activity of fibroblasts and angiogenesis activity were revealed in the group of implanted 4 mm-collagen plates.
Summary: the experimental results allow the use of the collagen plate in the surgical treatment of postradiation urogenital fistulas.
##article.author.about##
O. B. Loran
Russian Medical Academy of Postgraduate Education
Россия
Department of Urology and Surgical Andrology
Россия
Department of Urology and Surgical Andrology
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1. Кан Д.В. «Руководство по акушерской и гинекологической урологии», 2-е изд. – M: Медицина, - 1986. - C. 49-67.
2. Лоран О.Б., Дементьева А.В., Твердохлебов Н.Е. «Лечение больных со сложными мочевыми свищами» // Врач, - 2008. - №8. C.45-47.
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Loran O.B. APPLICATION OF COLLAGEN MATRIX – AN INNOVATION IN SURGERY OF POSTRADIATION VESICO-VAGINAL FISTULAS. Medical Herald of the South of Russia. 2014;(4):74-78. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-74-78
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