FEATURES OF IMMUNE SYSTEM AT PATIENTS WITH THE PLOSKOKLETOCHNY CANCER OF SKIN

Abstract

Purpose: to study a condition of the immune status at patients with a cutaneous squamous cell carcinoma in the postoperative period.

Materials and methods: changes of the immune status it is carried out at 39 patients with a squamous cell carcinoma of the skin. Th e age of patients made 65 Ѓ} 3 years. At all patients the stage of a disease made T1-2N0M0. Researches were conducted before expeditious treatment, in the fi rst postoperative days, for the fi ft h, seventh, tenth postoperative days and in 18 months aft er the undergone operation. When studying the immune status the main indicators humoral and cellular links of immunity were defi ned.

Results: in a cellular link of system of immunity at patients with a squamous cell carcinoma of the skin before the carriedout expeditious treatment decrease in both relative, and absolute number of the lymphocytes bearing receptors of CD16+, CD3+,CD4+, CD8+ which considerably increased by the tenth postoperative days is noted. In a humoral link of system of immunity at patients with a squamous cell carcinoma of the skin decrease in quantity of IgG, M, and also total of a complement, its S3-and C4 fractions, a tumor necrosis factor, SILT 1β, 6,10, interferon, a phagocytic index is registered, a Nitroblue tetrazolium spontaneous and stimulated by Zymosanum, thus the increase in the circulating immune complexes was noted.

Summary: partial restoration of IgG, M happens for the tenth postoperative days.