Features of innate and adaptive immunity in patients with COVID-19 coronavirus infection
https://doi.org/10.21886/2219-8075-2025-16-1-106-111
Abstract
Objective: to study the immunological parameters of patients who had suffered from COVID-19 in moderate form 1 and 6 months after recovery. Materials and methods: 60 patients hospitalized with the diagnosis of "COVID-19, moderate form; complication: interstitial pneumonia" were examined. Immunological parameters were assessed 1 month and 6 months after recovery. Comparison group: 20 healthy volunteers. Results: after six months, signs of immune dysfunction continue to persist in the immune status, consisting in a violation of the processes of differentiation and proliferation of immunocompetent cells. Conclusion: the need for immunological monitoring in people who have had COVID-19 for 6 months in order to identify immunodeficiency conditions and prevent infectious diseases against this background is shown.
About the Authors
L. P. Sizyakina
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Lyudmila P. Sizyakina, Dr. Sci. (Med.), Prof., Head of the Clinical Immunology and Allergology Chair
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
N. A. Skripkina
City Hospital No. 1 named after N.A. Semashko
Russian Federation
Competing Interests:
Russian Federation
Nadezhda A. Skripkina, head of the infectious diseases department No.4
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
V. Ya. Zakurskaya
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vita Ya. Zakurskaya, assistant of the Department of Clinical Immunology and Allergology
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
D. V. Sizyakin
City Hospital No. 1 named after N.A. Semashko
Russian Federation
Competing Interests:
Russian Federation
Dmitry V. Sizyakin, Dr. Sci. (Med.), Prof., urology Chair, Rostov State Medical university; chief medical officer
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
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Review
For citations:
Sizyakina L.P., Skripkina N.A., Zakurskaya V.Ya., Sizyakin D.V. Features of innate and adaptive immunity in patients with COVID-19 coronavirus infection. Medical Herald of the South of Russia. 2025;16(1):106-111. (In Russ.) https://doi.org/10.21886/2219-8075-2025-16-1-106-111
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