A case of severe combined pathology in a late premature infant with hypoxic-ischemic damage to the central nervous system
L. V. Kravchenko,
S. B. Berezhanskaya,
O. Z. Puzikova,
A. A. Afonin,
M. S. Kasyan,
K. G. Matyukh,
V. A. Popova,
M. A. Levkovich,
I. I. Krukier,
I. V. Panova,
A. V. Moskovkina,
D. I. Sozaeva https://doi.org/10.21886/2219-8075-2025-16-1-62-67
Abstract
A clinical observation of severe combined pathology in a newborn child with congenital hypothyroidism against the background of hypoxic-ischemic damage to the central nervous system is presented. Thanks to an early screening examination for congenital hypothyroidism, on the second day of life, the child was promptly prescribed levothyroxine replacement therapy against the background of treatment of concomitant pathology, which led to positive dynamics in the course of the disease and prevented the progression of hypoxic symptoms. ischemic damage to the central nervous system. An adverse effect on the fetus of maternal pathology (acute respiratory viral infection, bacterial vaginosis, candidiasis, bacteriuria) has been demonstrated. The presence of the above factors subsequently led to a severe course of the neonatal period in a child with congenital hypothyroidism and the development of severe concomitant pathology. Early diagnosis of congenital hypothyroidism with immediate prescription of replacement therapy makes it possible to prevent the development of mental retardation in this cohort of newborns. In the future, systematic monitoring of the child by a pediatrician and endocrinologist is required, with dose adjustment of the drug if necessary.
About the Authors
L. V. Kravchenko
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Larisa V. Kravchenko, Dr. Sc. (Med.), lead researcher of the department of pediatric
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
S. B. Berezhanskaya
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Sofia B. Berezhanskaya, Dr. Sci. (Med.), Professor, Chief Researcher of the Pediatric Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
O. Z. Puzikova
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olesya Z. Puzikova, Dr. Sci. (Med.), Leading Researcher of Pediatric Departmen of the Pediatric Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
A. A. Afonin
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Alexander A. Afonin, Dr. Sci. (Med.), Professor Chief Researcher of the Pediatric Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
M. S. Kasyan
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Maria S. Kasyan, Cand. Sci. (Med.), Assistant of the Department of Childhood Diseases No. 2
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
K. G. Matyukh
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Karina G. Matyukh, student, Rostov State Medical University
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
V. A. Popova
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Victoria A. Popova, Dr. Sc. (Med.), Chief Researcher of Pediatric Department of the Pediatric Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
M. A. Levkovich
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Marina A. Levkovich, Dr. Sc. (Med.), Associate Professor, Leading Researcher, Department of Allergic and Autoimmune Diseases in Pediatrics, Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
I. I. Krukier
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Irina I. Krukier, Dr. Sci.(Bio.); leading researcher; obstetric and gynecological department
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
I. V. Panova
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Irina V. Panova, Dr. Sc. (Med.), Associate Professor, Professor of the Department of Pediatrics and Neonatology Rostov
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
A. V. Moskovkina
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Angela V. Moskovkina, Dr. Sc. (Med.), Leading Researcher of the Obstetric and Gynecological Department of the Pediatric Research Institute of Obstetrics and Pediatrics
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
D. I. Sozaeva
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Diana I. Sozaeva, Dr. Sc. (Med.), Position of Pediatric Departmen of the Pediatric Research Institute of Obstetrics and Pediatrics
Competing Interests:
Authors declare no conflict of interest
References
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For citations:
Kravchenko L.V., Berezhanskaya S.B., Puzikova O.Z., Afonin A.A., Kasyan M.S., Matyukh K.G., Popova V.A., Levkovich M.A., Krukier I.I., Panova I.V., Moskovkina A.V., Sozaeva D.I. A case of severe combined pathology in a late premature infant with hypoxic-ischemic damage to the central nervous system. Medical Herald of the South of Russia. 2025;16(1):62-67. (In Russ.) https://doi.org/10.21886/2219-8075-2025-16-1-62-67
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