URINARY EXCRETION OF IL-1β, MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND TRANSFORMING GROWTH FACTOR-
https://doi.org/10.21886/2219-8075-2015-1-44-50
Abstract
Purpose: to evaluate the daily urinary excretion of markers of infl ammation (IL-1β, MCP-1) and transforming growth factor (TGF-β1) in women with type 1 diabetes with diff erent levels of daily albuminuria in diff erent trimesters of pregnancy.
Materials and methods: the study involved 48 women with type 1 diabetes and 24 women with physiological pregnancy in diff erent trimesters of pregnancy. Quantitative determination of the daily urinary excretion of IL-1β, MCP-1 and TGF-β1 was measured by enzyme-linked immunosorbent assay (ELISA).
Results: pregnant women with type 1 diabetes with normoalbuminuria (NAU) have comparable values of urinary excretion of IL-1β, MCP-1 and TGF-β1 with healthy pregnant women in all trimesters of pregnancy (r>0,05). In groups of pregnant women with microalbuminuria (MAU) and proteinuria (PU) there are an intensive increase in excretion of IL-1β, MCP-1 and TGF-β1.
Summary: level of IL-1β, MCP-1 and TGF-β1 in pregnant women with type 1 diabetes with MAU and PU signifi cantly higher than in the group with NAU in all trimesters, in the group with NAU they are comparable with the results of healthy pregnant women.
About the Authors
G. R. Gazizova
Kazan State Medical University, Department of hospital therapy with the course of endocrinology
Russian Federation
Russian Federation
F. V. Valeeva
Kazan State Medical University, Department of hospital therapy with the course of endocrinology
Russian Federation
Russian Federation
L. R. Gaysina
Kazan State Medical University, Department of hospital therapy with the course of endocrinology
Russian Federation
Russian Federation
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Review
For citations:
Gazizova G.R., Valeeva F.V., Gaysina L.R. URINARY EXCRETION OF IL-1β, MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND TRANSFORMING GROWTH FACTOR-. Medical Herald of the South of Russia. 2015;(1):44-50. (In Russ.) https://doi.org/10.21886/2219-8075-2015-1-44-50
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