COMPARATIVE ANALYSIS OF EFFICIENCY OF SEROLOGICAL SCREENING METHODS FOR EPIGENETIC AND COLON CANCER
https://doi.org/10.21886/2219-8075-2014-2-45-49
Abstract
Purpose: Comparative analysis serologic screening techniques of epigenetic and colon cancer for adequate screening and diagnostic algorithms for detection of colorectal cancer.
Materials and methods: Surveyed 204 patients whose colon cancer was detected in screening activities. A control group consisted of 56 healthy people. Screening measures unite following techniques: Immunochromatographic fecal occult blood, determination of tumor markers in the blood (carcinoembryonic antigen, oncoantigens CA 19-9, CA 242), methylated DNA gene septins 9 in the blood. The ROC-analysis determined the significance of diagnostic tests and their aggregation.
Results: Diagnostic efficacy of colon cancer screening by blood levels of CEA, CA 242 and CA 19-9, respectively, 40,4%, 50,8%, 51,7%. Epigenetic testmetilat DNASEPT9of blood as screening method is characterized by a high diagnostic sensitivity-85,3%.
Summary: At the initial stage of colon cancer screening method is a combination of the optimal combination of immunochemical test for the occult blood in feces in the threshold of 100 ng/ml, metilat DNA detection of SEPT9 gene in the blood.
Materials and methods: Surveyed 204 patients whose colon cancer was detected in screening activities. A control group consisted of 56 healthy people. Screening measures unite following techniques: Immunochromatographic fecal occult blood, determination of tumor markers in the blood (carcinoembryonic antigen, oncoantigens CA 19-9, CA 242), methylated DNA gene septins 9 in the blood. The ROC-analysis determined the significance of diagnostic tests and their aggregation.
Results: Diagnostic efficacy of colon cancer screening by blood levels of CEA, CA 242 and CA 19-9, respectively, 40,4%, 50,8%, 51,7%. Epigenetic testmetilat DNASEPT9of blood as screening method is characterized by a high diagnostic sensitivity-85,3%.
Summary: At the initial stage of colon cancer screening method is a combination of the optimal combination of immunochemical test for the occult blood in feces in the threshold of 100 ng/ml, metilat DNA detection of SEPT9 gene in the blood.
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Review
For citations:
Burtsev D.V. COMPARATIVE ANALYSIS OF EFFICIENCY OF SEROLOGICAL SCREENING METHODS FOR EPIGENETIC AND COLON CANCER. Medical Herald of the South of Russia. 2014;(2):45-49. (In Russ.) https://doi.org/10.21886/2219-8075-2014-2-45-49
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