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ПОЛИМОРФИЗМЫ ГЕНОВ КАК ФАКТОР РИСКА РАЗВИТИЯ ОСТЕОАРТРОЗА

https://doi.org/10.21886/2219-8075-2014-2-13-20

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Аннотация

Известно, что остеоартроз как распространенная форма дегенеративной патологии сустава имеет важный генетический компонент. Проведен анализ литературных источников, касающихся роли различных кандидатных генов в развитии остеоартроза, при этом много внимания уделено полиморфизму генов матриксных металлопротеиназ, их ингибиторов и генов интерлейкинов. Статья детально описывает результаты современных полногеномных анализов и мета-анализов ассоциаций полиморфизмов с данным заболеванием. Также обсуждается вопрос связи эпигенетических изменений и риска развития остеоартроза.

Об авторе

С. Б. Панина
Южный федеральный университет
Россия
кафедра биохимии и микробиологии


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Для цитирования:


Панина С.Б. ПОЛИМОРФИЗМЫ ГЕНОВ КАК ФАКТОР РИСКА РАЗВИТИЯ ОСТЕОАРТРОЗА. Медицинский вестник Юга России. 2014;(2):13-20. https://doi.org/10.21886/2219-8075-2014-2-13-20

For citation:


Panina S.B. GENETIC POLYMORPHISMS AS THE RISK FACTOR IN THE DEVELOPMENT OF OSTEOARTHRITIS. Medical Herald of the South of Russia. 2014;(2):13-20. (In Russ.) https://doi.org/10.21886/2219-8075-2014-2-13-20

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