DIAGNOSIS OF HYPOXIC-ISCHEMIC CENTRAL NERVOUS SYSTEM INJURIES IN A NEWBORN BABY
https://doi.org/10.21886/2219-8075-2013-4-131-134
Abstract
Purpose: to determine the diagnostic value of Doppler velocimetry with reference to neurospecific compounds during the early neonatal period depending on the delivery management.
Materials and methods: 65 pregnant women and newborns were examined. They were retrospectively divided into three clinical groups formed according to neonatologists`s final diagnosis in newborns. Before delivery pregnant women had Doppler velocimetry.
Results: by progressing hypoxemia there is a dilation of the medial cerebral artery of the fetus resulting in the increase of oxygenation of brain tissue of the fetus and in the increase of specific markers of neurologic disturbances.
Conclusion: determination of neurospecific proteins in umbilical blood in newborns is an early method of detection of the central nervous system injury permitting to diagnose pathological conditions and prognosticate a delayed manifestation of brain damages on time without reference to the delivery method.
About the Authors
N. N. Popova
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
Obstetrics and Gynecology Department.
43, Mechnikova Str., Rostov-on-Don, 344012A. V. Orlov
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
Obstetrics and Gynecology Department.
43, Mechnikova Str., Rostov-on-Don, 344012G. V. Smolyaninov
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
Obstetrics and Gynecology Department.
43, Mechnikova Str., Rostov-on-Don, 344012E. O. Shkotova
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
Obstetrics and Gynecology Department.
43, Mechnikova Str., Rostov-on-Don, 344012References
1. Баранов А.А., Щеплягина Л.А., Ильин А.Г. Состояние здоровья детей как фактор национальной безопасности // Российский педиатрический журнал.— 2005.— № 2.—С. 4-7.
2. Феоктистова Т.Е. Мониторинг адаптационных реакция плода в III триместре беременности, осложненных гестозом : Автореф. дис. канд. мед. наук.— Ростов на Дону, 2009. — 21 с.
3. Голосная Г.С. Изменение уровня белка S-100 у новорожденных с перинатальным гипоксическим поражением ЦНС // Педиатрия.— 2004. — № 1.— С. 10-15.
4. Афанасьева Н.В., Стрижаков А.Н. Исходы беременности и родов при ФПН различной степени тяжести // Вопросы гинекологии, акушерства и перинатологии. — 2004. — Т.3, № 2. — С. 7-13.
5. Gazzolo D. S100B Protein is increased in asphyxiated term infants developing intraventricular hemorrhage / D. Gazzolo, R. Di Iorio, E. Marinoni // Crit. Care Med. — 2002. Vol. 30. — P. 1356–1360.
6. Meynaar I.A. Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study / I.A. Meynaar, H.M. Oudemans-van Straaten, P. van der Wetering // Int Care Med. — 2003. Vol. 29. — P. 189–195.
7. Викторов И.В. Роль оксида азота и других свободных радикалов в ишемической патологии мозга // Вестник РАМН. — 2000. — № 4. — С. 5–11.
8. Пальчик А. Б. Гипоксически-ишемическая энцефалопатия новорожденных : руководство для врачей / А.Б. Пальчик, Н.П. Шабалов. — Санкт- Петербург : Питер, 2000. — 224 с.
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For citations:
Popova N.N., Orlov A.V., Smolyaninov G.V., Shkotova E.O. DIAGNOSIS OF HYPOXIC-ISCHEMIC CENTRAL NERVOUS SYSTEM INJURIES IN A NEWBORN BABY. Medical Herald of the South of Russia. 2013;(4):131-134. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-131-134
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