THE FACTORS OF CELLULAR REGULATION OF THE UTERUS CONTRACTIVE ACTIVITY BY PHYSIOLOGICAL ACT OF DELIVERY AND BY UTERINE INERTIA
https://doi.org/10.21886/2219-8075-2013-4-111-114
Abstract
Purpose. To develop a method of prediction of primary uterine inertia on the basis of study of cytokine and vasoactive bioregulator content dynamics.
Materials and methods. The material for the research was blood of women taken in the end of gestation (38-40 weeks) and also in the I period of delivery over time from 23 women with physiological act of delivery and from 19 – with uterine inertia.
Results. By primary uterine inertia there is an increase of relaxin production by 2 times and a decrease of TNF-α production: before delivery – by 1.5 times, during delivery – by 2 times, relative to the data by physiological delivery. Differently directed changes of TGF-β1 and IL-1β content – increase of the first one and decrease of the second one – are one of the reasons of low generation of nitric oxide as a result of reduction of NO-synthase activity under the action of these cytokines. High level of relaxin neutralizes the endogenous oxytocin action and the decrease of TNF-α and nitric oxide production causes changes in the content of intracellular calcium in myometrium cells.
Summary: The detected character of the intracellular regulation disturbance of the uterus contractive activity is a basis for the development of uterine inertia.
About the Authors
M. G. Nekrasova
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
V. A. Kulakova
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
T. N. Pogorelova
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
N. A. Drukker
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
V. A. Linde
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
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Review
For citations:
Nekrasova M.G., Kulakova V.A., Pogorelova T.N., Drukker N.A., Linde V.A. THE FACTORS OF CELLULAR REGULATION OF THE UTERUS CONTRACTIVE ACTIVITY BY PHYSIOLOGICAL ACT OF DELIVERY AND BY UTERINE INERTIA. Medical Herald of the South of Russia. 2013;(4):111-114. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-111-114
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