DYNAMICS OF CHANGES OF THE HEMATOKRIT LEVEL IN NEWBORNS IN CRITICAL CONDITIONS IN RESPONSE TO SELENASE’S INTRODUCTION
https://doi.org/10.21886/2219-8075-2013-4-65-69
Abstract
Purpose: To improve the results of treatment of newborns with respiratory distress syndrome (RDS) and perinatal CNS (central nervous system PP), being in critical conditions, by selenium use.
Materials and Methods: blind, controlled, randomized clinical trial application of selenase in newborn babies with RDS and PP CNS with artificial ventilation (AV) was carries out. 76 newborn children being in a critical condition were surveyed. Randomization was carried out by a computer program of a random number generator. In Group I (n = 36), selenase was entered in doses of 10 mg / kg / day intravenously slowly for 10 days, II group (n = 40) - control group.
Results: during the test it was found and statistically proved that the group of children receiving selenase, there is an increase by 1,01 times (р < 0,05) level of hematocrit.
Summary: level increase of hematocrit, promoted decrease (by 1,1 times) frequencies of development of anemias at children of the I group and by that, reduced the duration of carried-out IVL and hospitalization duration.
About the Authors
L. F. DolotovaRussian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
V. V. Estrin
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
References
1. Шабалов Н.П. Неонатология: Учебное пособие: В 2 т. / Н.П. Шабалов. – Т.II. – 3-е изд., исправл. и доп. – М.: МЕДпрессинформ, 2004. - 640 с.
2. Приказ Минздрава РФ от 25.11.2002. № 363 «Об утверждении Инструкции по применению компонентов крови».
3. Гоголева И.В., Громова О.А. Селен. Итоги и перспективы применения в педиатрии// Практика педиатра. – 2009. - № 3. – С. 6-9.
4. Авцын А.П., Жаворонков А.А., Рош М.А., Строчкова Л.С. Микроэлементозы человека. - М.: Медицина, 1991. - 496 с.
5. Дубина Е.Е. Некоторые особенности функционирования ферментной антиоксидантной защиты плазмы крови человека / Е.Е. Дубина // Биохимия. - 2005. - № 2. - С. 3-18.
6. Гмошинский И.В., Мазо В.К., Тутельян В.А., Хотимченко С.А. Микроэлемент селен: роль в процессах жизнедеятельности: обзорная информация //Экология моря, НАН Украины.- 2000. - №54. – С. 83–6.
7. Daniels L., Gibson R., Simmer K. Selenium status of preterm infants: the effect of postnatal age and method of feeding// Acta Paediatr. 1997. 86. P.281-288.
8. Angstwurm M.W.A, Engelmann L., Zimmermann T. et al. 2007. Selenium in Intensive Care (SIC) Study: Results of a prospective randomised, placebocontrolled, multiple-centre study in patients with severe systemic inflammatory response syndrome, sepsis and septic shock. // Crit. Care Med. V.35. P.118-126.
9. Шестопалов А.Е., Дмитриев А.В. Микроэлементные ком- плексы в клинической медицине. URL: http://medi.ru/ doc/321301.htm (дата обращения 12.04.2013).
10. Chugh SN, Jain S, Agrawal N, Sharma A. Evaluation of oxidative stress before and after haemodialysis in chronic renal failure. J Assoc Physicians India. 2000; 48(10):981-4.
11. Назаренко Г.И., Кишкун А.А. Клиническая оценка результатов лабораторных исследований. http://www.pointofviewonline.ru/literature/2_266.html от 22.08.2013 (09:29) (дата обращения 12.04.2013).
Review
For citations:
Dolotova L.F., Estrin V.V. DYNAMICS OF CHANGES OF THE HEMATOKRIT LEVEL IN NEWBORNS IN CRITICAL CONDITIONS IN RESPONSE TO SELENASE’S INTRODUCTION. Medical Herald of the South of Russia. 2013;(4):65-69. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-65-69