PECULIARITIES OF VASCULO-ENDOTHELIAL GROWTH FACTORS’ SYSTEM IN PHYSIOLOGICAL PREGNANCY IN DEPENDENCE ON FETAL SEX
https://doi.org/10.21886/2219-8075-2013-4-38-42
Abstract
Purpose: To investigate the peculiarities of vasculo-endothelial growth factors’ system in physiological pregnancy in dependence on fetal sex.
Material and Methods: We studied 107 women with physiological pregnancy, 52 with male fetuses, 55 with female. We studied the levels of vasculo-endothelial growth factor, placental growth factor, endothelial growth factor, endothelin-1, tumor necrosis factor-a levels in women in 1, 2 and 3 trimesters of pregnancy in dependence on factor “fetus sex”.
Results: We revealed significant differences of these indices in women with male and female fetuses in dependence on gestational age. We detected significant differences in the function of vasculo-endothelial growth factors’ system in dependence on fetal sex, indicating the existence of systemic preconditions to its anatomical and functional heterochronys.
Summary: There is a certain ratio of the absolute levels of the studied polypeptides in physiological pregnancy for each trimester. There were significant differences in their levels of sex of the fetus
About the Authors
T. L. Botasheva
Rostov-on-Don research institute of obstetrics and pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
V. A. Linde
Rostov-on-Don research institute of obstetrics and pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
N. V. Ermolova
Rostov-on-Don research institute of obstetrics and pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
O. D. Sargsyan
Rostov-on-Don research institute of obstetrics and pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
N. A. Rogova
Rostov-on-Don research institute of obstetrics and pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
References
1. Орлов, А.В. Скрининговые маркеры физиологической и осложненной беременности: автореф. дис. ... д-ра. мед. наук: 14.00.01 / А.В. Орлов Александр Владимирович. – Ростов н/Д, 2006. – 47 с.
2. Nanno, J.H. Plasma nitric oxide metabolite levels are decreased in preeclamptic women complicated with fetal distress / J.H. Nanno, N. Sagawa, H. Itoh et al. // Prenat. Neonat. Med. – 1998. – Vol. 3. – P. 222–226.
3. Геодакян, В.А. Роль полов в передаче и преобразовании генетической информации. / В.А. Геодакян // Пробл. передачи информ. - 1965. - Т. 1, № 1. - С. 105—112.
4. Jakeman, L.B. Axonal projections between fetal spinal cord transplants and the adult rat spinal cord: a neuroanatomical tracing study of local interactions / L.B. Jakeman, P.J. Reier // J. Comp. Neurol. – 1991. – Vol. 307. – Р.311–334.
5. Jakeman, L.B. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues / L.B. Jakeman, J. Winer, G.L. Bennett et al. // J. Clin. Invest. – 1992. – Vol. 89. – P. 249–253.
6. Lyall, F. Transforming growth factor-beta expression in human placenta and placental bed in third trimester normal pregnancy, preeclampsia, and fetal growth restriction / F. Lyall, H. Simpson, J.N. Bulmer et al. // Am. J. Pathol. – 2001. – Vol. 159, N 5. – P. 1827–1838.
7. Fedefe, A.O. Regulation of Gene Expression by the Hypoxia-inducible Factors / A.O. Fedefe, L.W. Murray, D.J. Peet // Molecular Interventions. –2002. – Vol.2. – P.229–243.
8. Гомазков, О.А. Cистема эндотелиновых пептидов: механизмы кардиоваскулярных патологий / О.А. Гомазков // Вопр. мед. химии. – 1999. – Т. 45, № 4. – С. 290–303.
9. Kurz, H.A. New panoptic stain for developmental biology - the mouse placenta paradigm / H.А. Kurz, D. Wittekind // Ann. Anat. – 2001. – Vol.173, N 5. – P. 437–441.
10. Clark, D.E. Comparison of expression for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGFC in the human placenta throughout gestation / D.E. Clark, S.K. Smith, D. Licence et al. // J. Endocrinol. – 1998. – Vol. 159. – P. 459–467.
Review
For citations:
Botasheva T.L., Linde V.A., Ermolova N.V., Sargsyan O.D., Rogova N.A. PECULIARITIES OF VASCULO-ENDOTHELIAL GROWTH FACTORS’ SYSTEM IN PHYSIOLOGICAL PREGNANCY IN DEPENDENCE ON FETAL SEX. Medical Herald of the South of Russia. 2013;(4):38-42. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-38-42
Views:
424
Email this article 